Pascal Van Hentenryck, A. Russell Chandler III Chair and Professor in the H. Milton Stewart School of Industrial and Systems Engineering (ISyE) at Georgia Tech, director of Tech AI, and director of NSF AI4OPT, was a keynote speaker at AI Festival 2025, held December 1–3 at TU Wien Informatics in Vienna, Austria.

The three-day international festival convened leading researchers, industry experts, and members of the public to explore how artificial intelligence is shaping science, technology, and society. Through keynote talks, panels, and interactive sessions, the event fostered dialogue around emerging AI research, real-world applications, and societal impact.

Van Hentenryck delivered a keynote on “AI for Engineering Optimization” during Day 1: Research, which focused on recent advances in foundational and applied AI. His talk highlighted how AI and optimization methods can be integrated to address complex engineering challenges, with implications for domains such as energy systems, mobility, and large-scale decision-making. 

The session was chaired by Nysret Musliu of TU Wien and the Cluster of Excellence Bilateral AI (BilAI).

The research-focused first day of the festival featured discussions on topics including neurosymbolic AI, large language models, explainable AI, AI in science, and automated problem solving and decision-making. Van Hentenryck’s keynote contributed to these conversations by emphasizing the role of AI-driven optimization in advancing engineering design and operational efficiency.

AI Festival 2025 was co-organized by TU Wien, the Center for Artificial Intelligence and Machine Learning (CAIML), BilAI—funded by the Austrian Science Fund (FWF)—the Vienna Science and Technology Fund (WWTF), and TU Austria. The event underscored the importance of international collaboration across academia and industry in advancing responsible and impactful AI research.

Van Hentenryck’s participation reflects Georgia Tech’s leadership in artificial intelligence, as well as the missions of Tech AI and AI4OPT to advance AI-enabled optimization and decision-making for complex, real-world systems.

From zero to working prototype in just four months, students in the College of Computing’s new entrepreneurial Junior Design Capstone tackle real-world problems with guidance from startup mentors.

Supply chain management is poised to enter a new era. The Harvard Business Review has published a groundbreaking article co-authored by Andre Calmon, associate professor of operations management, alongside Flavio Calmon, Harvard University; Carol Long, Harvard University; and David Simchi-Levi, Massachusetts Institute of Technology. “The Age of Autonomous Supply Chains Has Arrived” explores how generative AI is transforming supply chain management from automated systems to truly autonomous operations.
 

Based on data collected at the Scheller College of Business, Calmon’s research demonstrates how AI models like Llama 4 Maverick 17B—equipped with optimized prompts, data-sharing rules, and guardrails—can outperform human teams in managing complex supply chains. Using the classic MIT Beer Distribution Game as a testbed, the authors benchmarked AI agents against more than 100 Georgia Tech students. The results were striking: AI-driven systems reduced total supply chain costs by up to 67% compared to human performance.
 

Traditional automated systems rely on rigid, human-designed rules. Calmon and his co-authors employed autonomous agents that learn, adapt, and coordinate across functions in real time. The study highlights four critical factors for success: selecting capable reasoning models, implementing guardrails to prevent costly errors, curating data through orchestration, and refining prompts for optimal performance.
 

“This breakthrough positions the Scheller College of Business as a thought leader at the intersection of AI and supply chain innovation,” said Calmon. “World-class supply chain management is becoming a plug-and-play capability. Businesses that understand how to guide generative AI agents with the right data and policies will gain a decisive competitive edge.”
 

The implications extend beyond cost savings. By delegating operational decisions to autonomous systems, human managers can focus on strategic priorities such as network design and supplier relationships. In an era of global volatility, this research emphasizes how future supply chain success depends on the strategic use of AI-driven technology.
 

Read More: Harvard Business Review 

The AI4Science Center has announced the first recipients of its semiannual seed grant competition. Supported by the Schools of Chemistry and Biochemistry, Physics, and Psychology, the seed grant aims to support the development of research projects centered on innovation and collaboration. 

“The selection committee received more than a dozen proposals that push the boundaries of AI-enabled science and encourage collaboration across units. I look forward to seeing the great science, strong results, and successful future external funding enabled by these seed grants,” says Dimitrios Psaltis, professor in the School of Physics and director of the AI4Science Center. 

Launched earlier this semester, the center promotes cross-disciplinary research on AI tools that address scientific challenges. The following three proposals were selected by the center based on their scientific goals, extent of interdisciplinary collaboration, and potential for outside funding: 

Spring 2026 AI4Science Center Seed Grant Recipients  

Graph Foundation Models for Protein Conformational Dynamics | School of Chemistry and Biochemistry 

• PIs: Professor Peter Kasson, School of Chemistry and Biochemistry; Professor JC Gumbart, School of Physics; Assistant Professor Amirali Aghazadeh, School of Electrical and Computer Engineering
• Graduate student: Jeffy Jeffy
• Team statement: “The AI4Science Center’s seed funding will allow us to complete and test a prototype of our new deep learning architecture for protein dynamics. We're super excited about the project and happy that this gives us support to pursue our new idea.”

Combinations of Verified AI and Domain Knowledge for New Insights in Theoretical Physics | School of Physics

• PIs: Assistant Professor Aishik Ghosh, School of Physics; Professor Vijay Ganesh, School of Computer Science
• Graduate student: Piyush Jha
• Team statement: “This seed funding gives us an opportunity to connect two fields in a way that could transform our approach to certain problems in theoretical physics.”

Harnessing the Manifold Geometry of Neural Representations for Robust LLM Safety | School of Psychology 

• PIs: Assistant Professor Audrey Sederberg, School of Psychology; Assistant Professor Pan Li, School of Electrical and Computer Engineering
• Graduate student: Ruixuan Deng
• Team statement: “Our project injects insights from human neuroscience directly into AI safety algorithm design, allowing us to move beyond black-box approaches toward more interpretable and principled safety mechanisms. By closing the loop, these computational models will also provide new feedback and insights for neuroscience.”

Ph.D. student Ziqi Zhang has built a career blending machine learning with single-cell biology. His work helps scientists study cellular mechanisms that advance disease research and drug development.

Though decorated with awards and appearances in leading journals, Zhang will achieve his greatest accomplishment tonight at McCamish Pavilion. He will join the Class of 2025 in walking across the stage, receiving diplomas, and graduating from Georgia Tech.

Before he “gets out” of Georgia Tech, we interviewed Zhang to learn more about his Ph.D. journey and where his degree will take him next. 

Graduate: Ziqi Zhang

Research Interests: Machine learning, foundational models, cellular mechanisms, single-cell gene sequencing, gene regulatory networks

Education: Ph.D. in Computational Science and Engineering

Faculty Advisor: School of CSE J.Z. Liang Early-Career Associate Professor Xiuwei Zhang

What persuaded you to study at Georgia Tech? 

I chose Georgia Tech because it is one of the top engineering institutions in the United States, known for its strength in machine learning and data science. The university offers exceptional research resources and the opportunity to work with leading scholars in my field. Georgia Tech also has very good research infrastructure. The Coda Building is one of the most well-designed and productive research environments I have experienced. Having access to such a space has been a genuine privilege.

How has working on your CSE degree helped you so far in your career?

Working toward my CSE degree has been instrumental in my career development. As an interdisciplinary program, CSE has equipped me with strong computational skills while also deepening my understanding of key application domains. This breadth of training has opened more opportunities during my job and internship searches. In addition, CSE community events, such as HotCSE, the weekly coffee hour, and faculty recruiting activities, have helped me strengthen my scientific communication skills, which are essential for my long-term career growth.

What research project from Georgia Tech are you most proud of?

My favorite research project was scMoMaT, a matrix tri-factorization algorithm for single-cell data integration. I invested a significant amount of time and effort into this work, iterating on the model many times. I’m very proud that it ultimately evolved into a clean, robust, and elegant algorithm.

What advice would you give someone interested in graduate school?

It is important to find an advisor who is supportive and genuinely invested in your career development. A Ph.D. is not an easy journey, and you will inevitably encounter challenges along the way. Having an advisor who can provide thoughtful guidance and dedicated mentorship is one of the most crucial factors in helping you navigate those difficulties.

What is your most favorite memory from Georgia Tech?

CSE’s new student campus visit day every year was one of my favorite times of the year. It was always fun to meet new people, have good food, and enjoy the beautiful view from the Coda rooftop.

What are your plans after graduation?

I plan to keep working in academia after graduation. I’m on the job hunt, currently applying for positions and preparing for interviews.

Proteins, including antibodies, hemoglobin, and insulin, power nearly every vital aspect of life. Breakthroughs in protein research are producing vaccines, resilient crops, bioenergy sources, and other innovative technologies.

Despite their importance, most of what scientists know about proteins only comes from a small sample size. This stands in the way of fully understanding how most proteins work and unlocking their full potential.

Georgia Tech’s Yunan Luo believes artificial intelligence (AI) could fill this knowledge gap. The National Science Foundation agrees. Luo is the recipient of an NSF Faculty Early Career Development (CAREER) award. 

“So much of biology depends on knowing what proteins do, but decades of research have concentrated on a relatively small set of well-studied proteins. This imbalance in scientific attention leads to a distorted view of the biological landscape that quietly shapes our data and our algorithms,” Luo said.

“My group’s goal is to build machine learning (ML) models that actively close this gap by generating trustworthy function predictions for the many proteins that remain understudied.”

[Related: Yunan Luo to use AI for Protein Design and Discovery with Support of $1.8 Million NIH Grant]

In his proposal to NSF, Luo coined this rich-get-richer effect “annotation inequality.” 

One problem of annotation inequality is that it slows progress in disease prognosis, drug discovery, and other critical biomedical areas. It is challenging to innovate the few proteins that scientists already know so much about. 

A cascading effect of annotation inequality is that it diminishes the effectiveness of studying proteins with AI.  

AI methods learn from existing experimental data. Datasets skewed toward well-known proteins propagate and become entrenched in models. Over time, this makes it harder for computers to research understudied proteins. 

“Protein annotation inequality creates an effect analogous to a vast library where 95% of patrons only read the top 5% popular books, leaving the rest of the collection to gather dust,” Luo said.

“This has resulted in knowledge disparities across proteins in current literature and databases, biasing our understanding of protein functions.”

The NSF CAREER award will fund Luo with over $770,000 for the next five years to tackle head-on the problem of protein annotation inequality.

Luo will use the grant to build an accurate, unbiased protein function prediction framework at scale. His project aims to:

• Reveal how annotation inequality affects protein function prediction systems
• Create ML techniques suited for biological data, which is often noisy, incomplete, and imbalanced  
• Integrate data and ML models into a scalable framework to accelerate discoveries involving understudied proteins

More enduring than the ML framework, Luo will leverage the NSF award to support educational and outreach programs. His goal is to groom the next generation of researchers to study other challenges in computational biology, not just the annotation inequality problem.

Luo teaches graduate and undergraduate courses focused on computational biology and ML. Problems and methods developed through the CAREER project can be used as course material in his classes.

Luo also championed collaboration with Georgia Tech’s Center for Education Integrating Science, Mathematics, and Computing (CEISMC) in his proposal. 

Through this partnership, local high school teachers and students would gain access to his data and models. This promotes deeper learning of biology and data science through hands-on experience with real-world tools.  

Luo sees reaching students and the community as a way of paying forward the support he received from Georgia Tech colleagues. 

“I am incredibly grateful for this recognition from the NSF,” said Luo, an assistant professor in the School of Computational Science and Engineering (CSE). 

“This would not have been possible without my students and collaborators, whose hard work laid the groundwork for this proposal.”

Luo praised CSE faculty members B. Aditya Prakash, Xiuwei Zhang, and Chao Zhang for their guidance. All three study machine learning and computational bioscience, two of CSE’s five core research areas. 

Luo also thanked Haesun Park for her support and recommendation for the CAREER award. Park is a Regents’ Professor and the chair of the School of CSE.

The Institute for Matter and Systems (IMS) hosted the inaugural Boundaries and Breakthroughs panel on Nov. 11, setting the stage for a new era of interdisciplinary dialogue at Georgia Tech. The event, held in the Marcus Nanotechnology building, brought together experts in electrical engineering, computer architecture, and computer systems design to tackle one of today’s pressing challenges: artificial intelligence (AI) scalability and sustainable high-performance computing.

As one of Georgia Tech’s 11 interdisciplinary research institutes, IMS is designed to break down silos between traditional academic units. By operating core user facilities and fostering collaborative research, IMS creates a unique ecosystem where device-level innovation meets systems-level design. This event personified that mission by connecting researchers who typically work on different ends of the stack.

“We’re looking for opportunities to bring people together to have discussions that are both informative and potentially create a little bit of friction in the best possible way around trending topics in science and engineering,” said Mike Filler, IMS deputy director, during opening remarks.

The panel was moderated by Divya Mahajan, assistant professor in the School of Electrical and Computer Engineering, and featured Moinuddin Qureshi, professor of computer science; Anand Iyer, assistant professor of computer science; and Asif Khan, associate professor in electrical and computer engineering. 

The discussion explored the dynamics between compute abundance and energy constraints. As AI models scale up, power consumption has become a societal issue, driving up energy demands and even influencing political conversations. The panelists agreed that the bottleneck isn’t compute — a computer’s ability to process and execute tasks — but data movement. Moving data uses 100 to 1,000 times more energy than computation, making memory systems the critical frontier.

The conversation highlighted how breakthroughs in compute must occur at every layer — from individual devices to full computer systems. At the device level, Khan mentioned emerging memory technologies and “beyond CMOS” approaches such as embedding compute within memory and exploring bio-inspired architectures.

From a computer architecture level, Qureshi advocated rethinking interfaces and creating designs optimized for the future of computing. AI needs regular patterns to work optimally, and current patterns are not set up for that.

“If you want efficiency, design systems that make sense for AI,” Qureshi said. “Develop new interfaces, develop new modules, architectures, and organization that make for a specific pattern.”

At the systems level, Iyer stressed practical strategies like near-memory compute and energy-aware scheduling while acknowledging the need for co-design between hardware and software.

“Now in terms of brains or bio-inspired computing, my conjecture is that there is currently no hardware that is capable of doing it,” Khan said. He also noted that right now, there is no computer or algorithm that has the scale of computing comparable to human brain power.

The panelists didn’t shy away from provocative ideas — such as whether graphic processing units are the final solution for AI and whether matrix multiplication alone can lead to artificial general intelligence. While opinions varied, all agreed that organizations like IMS are key to bringing together diverse expertise to tackle these questions collaboratively.

The Boundaries and Breakthroughs series continues in January with a panel on bioelectronics and medical technologies, reinforcing IMS’s commitment to fostering dialogue that spans the full spectrum of innovation.

Viral videos abound with humanoid robots performing amazing feats of acrobatics and dance but finding videos of a humanoid robot performing a common household task or traversing a new multi-terrain environment easily, and without human control, are much rarer. This is because training humanoid robots to perform these seemingly simple functions involves the need for simulation training data that lack the complex dynamics and degrees of freedom of motion that are inherent in humanoid robots. 

To achieve better training outcomes with faster deployment results, Fukang Liu and Feiyang Wu, graduate students under Professor Ye Zhao from the Woodruff School of Mechanical Engineering and faculty member of the Institute for Robotics and Intelligent Machines, have published a duo of papers in IEEE Robotics and Automation Letters. This is a collaborative work with three other IRIM affiliated faculties, Profs. Danfei Xu, Yue Chen, and Sehoon Ha, as well as Prof. Anqi Wu from School of Computational Science and Engineering.

To develop more reliable motion learning for humanoid robots and enable humanoid robots to perform complex whole-body movements in the real world, Fukang led a team and developed Opt2Skill, a hybrid robot learning framework that combines model-based trajectory optimization with reinforcement learning.  Their framework integrates dynamics and contacts into the trajectory planning process and generates high-quality, dynamically feasible datasets, which result in more reliable motion learning for humanoid robots and improved position tracking and task success rates. This approach shows a promising way to augment the performance and generalization of humanoid RL policies using dynamically feasible motion datasets. Incorporating torque data also improved motion stability and force tracking in contact-rich scenarios, demonstrating that torque information plays a key role in learning physically consistent and contact-rich humanoid behaviors.

While other datasets, such as inverse kinematics or human demonstrations, are valuable, they don’t always capture the dynamics needed for reliable whole-body humanoid control.” said by Fukang Liu. “With our Opt2Skill framework, we combine trajectory optimization with reinforcement learning to generate and leverage high-quality, dynamically feasible motion data. This integrated approach gives robots a richer and more physically grounded training process, enabling them to learn these complex tasks more reliably and safely for real-world deployment. - Fukang Liu

In another line of humanoid research, Feiyang established a one-stage training framework that allows humanoid robots to learn locomotion more efficiently and with greater environmental adaptability. Their framework, Learn-to-Teach (L2T), unlike traditional two-stage “teacher-student” approaches, which first train an expert in simulation and then retrain a limited-perception student, teaches both simultaneously, sharing knowledge and experiences in real time. The result of this two-way training is a 50% reduction in training data and time, while maintaining or surpassing state-of-the-art performance in humanoid locomotion. The lightweight policy learned through this process enables the lab’s humanoid robot to traverse more than a dozen real-world terrains—grass, gravel, sand, stairs, and slopes—without retraining or depth sensors.

By training an expert and a deployable controller together, we can turn rich simulation feedback into a lightweight policy that runs on real hardware, letting our humanoid adapt to uneven, unstructured terrain with far less data and hand-tuning than traditional methods. - Feiyang Wu

By the application of these training processes, the team hopes to speed the development of deployable humanoid robots for home use, manufacturing, defense, and search and rescue assistance in dangerous environments. These methods also support advances in embodied intelligence, enabling robots to learn richer, more context-aware behaviors.Additionally, the training data process can be applied to research to improve the functionality and adaptability of human assistive devices for medical and therapeutic uses.

As humanoid robots move from controlled labs into messy, unpredictable real-world environments, the key is developing embodied intelligence—the ability for robots to sense, adapt, and act through their physical bodies,” said Professor Ye Zhao. “The innovations from our students push us closer to robots that can learn robust skills, navigate diverse terrains, and ultimately operate safely and reliably alongside people. - Prof. Ye Zhao

Author - Christa M. Ernst

Citations

Liu F, Gu Z, Cai Y, Zhou Z, Jung H, Jang J, Zhao S, Ha S, Chen Y, Xu D, Zhao Y. Opt2skill: Imitating dynamically-feasible whole-body trajectories for versatile humanoid loco-manipulation. IEEE Robotics and Automation Letters. 2025 Oct 13.

Wu F, Nal X, Jang J, Zhu W, Gu Z, Wu A, Zhao Y. Learn to teach: Sample-efficient privileged learning for humanoid locomotion over real-world uneven terrain. IEEE Robotics and Automation Letters. 2025 Jul 23.
 

 

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The Georgia Tech Library is proud to show a new piece from Hyojin Kwon and Nix Liu Xin on the Media Bridge, Synthetic Ecologies: AI-Translated Matter in Architectural Media.

The four-minute piece, which went live in November, is playing every hour at the ten-minute mark on Media Bridge, located between Price Gilbert and Crosland Tower.

 

About Synthetic Ecologies: AI-Translated Matter in Architectural Media

Rather than accelerating images, Synthetic Ecologies asks “how matter thinks.” New Materialism treats matter as an active partner; design emerges where human intention intra-acts with things, datasets, models, and light. Authorship becomes orchestration, and every dataset a canon—a politics of selection. Method, therefore, is ethics.

The project authors a white model first, fixing space, camera, light, and motion as temporal logic. AI then enters as a translator, moving on rails of depth/normal/segmentation with flow consistency. The surface reveals signs of behavior—gloss, scattering, porosity, accretion—rather than mere style. We publish provenance—sources and biases, node graphs and parameters, timelines and versions—so choices are traceable and contestable, transferable to learning, practice, and public decision.

From plastic toward a synthetic ecology, the work declares architecture thinking with media. AI is not authority but a transparent amplifier; authorship is not surrendered.

Spanning the Library, the Media Bridge is a civic threshold of study and routine, a common ceiling shared day and night. Installed overhead, the flow of plastics becomes a sky that prompts daily audiences to reflect on circulation, responsibility, and bias. Open provenance turns the piece into a public manifesto, linking campus AI literacy and circularity agendas to civic practice. The work does more than show images; it proposes a public curriculum where data and decisions, materials and culture, negotiate in view of the community.

 

Artist Bios

Hyojin Kwon is an Assistant Professor in the School of Architecture at the Georgia Institute of Technology and cofounder of Pre- and Post-, a research-driven design practice based in Atlanta and Boston. Her work explores how digital media — including animation, simulation, and AI-assisted image workflows — can function as both generative and critical tools within architectural design. Situated within a post digital framework, her recent projects investigate material agency and synthetic ecologies, often translating computational processes into civic installations and experimental representations. Her work has been exhibited internationally, including at the Museum of Brisbane, Tokyo Designers Week, Seoul Foundation for Arts and Culture, and Atlanta Contemporary, and supported by institutions such as MacDowell, Art Omi, and Autodesk.

Nix Liu Xin is a spatial computing artist and director, Harvard graduate, and the founder & CEO of OI (Onceness Intelligence), an experiential-AI startup. He envisions a future where 4D–AI interfaces enable everyone to record life moments, relive memories, and design immersive spatial experiences through intelligent 4D media.

He was named to the AACYF 30 Under 30 and has received accolades such as the Harvard Design Studies Domain Award, the CGarchitect 3D Awards, and the MIT AI Film Hack Award for Best Picture. 

Additionally, Nix was featured as an artist at the Lianzhou Photography Biennale. He also co-founded the HarvardXR Conference and the Creative.Tech Community.