When Victor Espinosa was an undergraduate student in Bogotá, he kept running into the same problem every time he tried to order books or basic items online: He didn’t have a credit card. Instead, he had to give cash to someone who had a credit card and ask them to purchase for him. This wasn’t strange in Colombia. 

“It was frustrating, but it showed me how many people were being left out of the digital world,” Espinosa said. “In Colombia, only about two out of 10 people have a credit card. Cash is the main form of payment, but everything online requires digital access.”

That gap sparked the idea that would evolve into Loto Punto, a fintech startup building self-service kiosks to bridge the physical and digital worlds for unbanked communities. 

From a Single Problem to a Scalable Platform

Espinosa began his startup as an online platform for buying lottery tickets. He saw that customers didn’t trust the idea of a digital receipt because they were used to a printout, so he pivoted to a kiosk similar to the ones in U.S. grocery stores. Customers could walk up, insert cash, and print a lottery ticket instantly. 
“It worked, but it had a ceiling,” Espinosa said. “It only served people buying lottery tickets. We knew it wouldn’t scale.”

To address this, he expanded the kiosks to handle mobile phone top-ups, bill payments, and basic banking services. Then, in 2024, the company incorporated advanced technologies such as biometric recognition and blockchain. Stellar Blockchain, first a partner, later became an investor of the startup, which helped Loto Punto to enable low-cost, real-time digital transactions and remittances. 

Now, users can convert physical cash into digital value or withdraw cash from digital wallets through a single machine.

A Global Solo Founder

Espinosa is the sole founder of Loto Punto, supported now by a 10‑person team of highly specialized engineers, designers, and manufacturing experts. He is currently pursuing his master’s degree in computer science at Georgia Tech while leading the company through its next chapter as part of the CREATE-X Startup Launch Spring 2026 cohort. 

Finding CREATE-X and Finding a Community

Espinosa learned about CREATE-X during his first semester at Georgia Tech. In 2024, CREATE-X widened its Startup Launch program to include a spring cohort to give founders, particularly graduating seniors, another chance to go all-in on developing their startup.

Espinosa admits he didn’t expect much when he first learned about the program.

“I didn’t know universities had programs like this. In Colombia, we don’t have accelerators embedded inside universities with venture support and dedicated staff,” he said. “So, I assumed CREATE X would be small, maybe one office helping a few students.”

What Espinosa found was different.

“They’re leveraging every resource that Georgia Tech offers. They can help with any challenge by tapping the doors of the network they already have established,“ he said. “It’s an ecosystem.”

As a part of the Startup Launch program, CREATE-X brings in founders from its ecosystem to speak to participants and give them actionable insights — founders who have raised funds, been acquired, and have had other successes as entrepreneurs. 

“That’s different,” Espinosa said. “They’ve brought successful founders who have walked the talk. It’s different to interact with somebody who was already successful in doing what you’re doing.”

Testing, Measuring, and Learning Through Startup Launch

Even as a remote participant, Espinosa has connected well with his mentor, who meets with him weekly, and his mini-batch. During the program, startup teams are grouped together. They share their strategies, successes, and struggles as they develop throughout the program. Teams have weekly sprints where they focus on one or two activities and then measure those activities, which Espinosa said is helpful for maintaining focus and actually executing on ideas.

“If you, as an entrepreneur, start thinking of the whole world of activities that you must do to get somewhere with your startup, you won’t start,” he said. “By creating attainable goals, step by step, that’s how it compounds to reach bigger goals. But, you have to begin with something.”
Teams are also encouraged to take calculated risks.

“CREATE-X gives us a safe environment to test ideas,” Espinosa said. “As an entrepreneur, it’s a lonely road, but having someone who has been in your shoes before, it makes you brave to try things.”

One of the first major tests he shared with the cohort was an ad campaign timed around the Super Bowl. In Startup Launch, Espinosa learned how to structure the experiment: defining KPIs, iterating audiences, and evaluating performance compared to industry benchmarks.

“We got around 45,000 views and above-average click-through rates,” he said. “But the biggest lesson was that brand awareness alone can’t be our only marketing strategy.”

Espinosa said his mentor helped open doors for him and kept him accountable, and the program itself kept him from being overwhelmed by all that a founder has to do.

“In Startup Launch, you see how different approaches fit different phases,” he said. “They’re creating a path to grow and execute on your goals as a founder.”

Why Now Is the Easiest Time to Build

Espinosa also emphasized that the tools to build and test ideas have never been more accessible.

“When I started, we didn’t have AI. You had to do everything by hand. It was harder, and it took more resources,” he said. “Right now, it’s a matter of prompting. In one hour, you can file for a grant. Before, it took at least a week to get your documents together.”

He said the ability to test quickly and learn has also become inexpensive.

“You don’t need millions of dollars to do this,” Espinosa said. “It's very cheap to fail, right? If that doesn't work, you can just try again in the morning.”

Above all, Espinosa encouraged budding founders to take advantage of the opportunities around them.

“As a founder, you must tap every door that you have available to you. You have to explore different paths,” he said. “Some of those are networking, some are physical space, some are interest. Get your hands on every single resource that comes your way.”

Looking Ahead: The Future of Payments

As he thinks about where the finance world is going, Espinosa said the payments industry is rapidly converging toward blockchain, stablecoins, and faster, frictionless user experiences.

“We’re seeing a lot of movement around stablecoins. We’re seeing resource flow from one country to another. We believe things are converging to leverage blockchain and driving down the cost of moving money,“ he said. “That’s how we see the future of our industry.”

Meet Loto Punto and the Spring Cohort at Startup Launch Showcase

Espinosa will travel to Atlanta for the first time in May to present Loto Punto at the CREATE-X Spring Startup Launch Showcase, where the public can meet founders and see their ventures firsthand. The event will be held in The Biltmore Ballrooms on Thursday, May 21, from 5 to 7 p.m.

The showcase will feature dozens of startups built by Georgia Tech students and alumni. Tickets are free but limited. Register for the showcase today to grab your spot.
 

The 34th annual Suddath Symposium, hosted by the Parker H. Petit Institute for Bioengineering and Bioscience (IBB) on March 18-19, brought together researchers, trainees, and invited speakers from across disciplines to discuss cutting-edge efforts to translate synthetic biology advances into human health-relevant technologies, including diagnostics, therapeutics, and clinical tools.

“The topic of the Suddath Symposium changes every year, which allows the Georgia Tech research community to annually learn about recent advances on a specific topic from across the immense fields of bioengineering and bioscience,” said Nicholas Hud, Regents’ Professor in the School of Chemistry and Biochemistry and Associate Director of IBB.

The symposium also included presentation of the 2026 Suddath Award, which recognizes outstanding graduate research. This year’s award was presented to Myeongsoo Kim, a Ph.D. candidate in the Bioengineering Graduate Program, for his work at the intersection of cell engineering, cancer treatment, and biomedical imaging. The award is presented each year by members of the Suddath family, including Vincent Suddath, grandson of Bud and a current freshman at Georgia Tech majoring in mathematics.

The symposium and award honor the legacy of F. L. “Bud” Suddath and his lasting contributions to the Institute and the wider Georgia Tech research community.

“Bud was influential in promoting the growth of bioscience research at Georgia Tech, efforts that helped establish IBB in the 1990s,” Hud said. “Bud’s research interests were at the forefront of structural biology, a field that laid the foundation for much of what we know today about biology at the molecular level. It’s fitting that we honor Bud’s contributions by annually providing the Georgia Tech community with the opportunity to learn about research on a timely topic within the biological sciences.”

Symposium co-chairs Tara Deans and Mark Styczynski said that in addition to upholding the legacy of Bud Suddath, the event also provides a unique setting and opportunity for both established researchers and trainees to interact over the course of the two day event. The intimate format of the symposium, which is limited to approximately 100 attendees, and the annual selection of a different interdisciplinary topic sets it apart from other symposia.

“The Suddath Symposium is an amazing opportunity to bring multiple world-class researchers right to our trainees’ front door, to hear about their work and connect with them in a small setting that you can’t really find at most conferences,” said Styczynski, who is a professor in the School of Chemical and Biomolecular Engineering. “We are really grateful to IBB and the Suddath family for supporting this unique event.”

Deans, who is an associate professor in the Wallace H. Coulter Department of Biomedical Engineering, highlighted how this year’s theme reflects a broader shift in the field.

“This year’s focus on biomedical applications of synthetic biology highlights a major inflection point in the field: the transition from proof-of-concept systems to human health-relevant technologies,” she said. “The theme also reflects increasing convergence across disciplines; synthetic biology is no longer operating in isolation, but it is deeply intertwined with immunology, machine learning, diagnostics, and clinical translation. Addressing real-world biomedical problems requires this kind of integration, and the symposium captured that shift very clearly.”

The Suddath Symposium annually serves as a cornerstone event for Georgia Tech’s bioengineering and bioscience community — connecting researchers, honoring scientific legacy, and spotlighting the next generation of scientific innovation.

One day after the historic Artemis II launch, the College of Sciences welcomed more than 150 researchers, students, and community members to its signature Frontiers in Science conference. Held on April 2, the full-day event focused on space research guiding discovery and innovation.

As during previous editions, this year’s conference featured more than two dozen scientists, engineers, policy experts, and thought leaders from Georgia Tech and beyond, illustrating how collaboration across fields – from science and engineering to public policy and international affairs – helps to advance strategic research priorities. 

“Frontiers is about discovery and connections across disciplines and generations,” says Susan Lozier, dean of the College of Sciences and Betsy Middleton and John Clark Sutherland Chair. “This edition provided an inspiring glimpse into the future of space exploration and the many ways Georgia Tech is contributing to research and missions seeking answers to what lies beyond our planet.” 

Commitment to Space

Space research is a key institutional priority at Georgia Tech, which is home to numerous academic and research programs in planetary sciences, robotics, mission design, space policy, and other areas. 

The recently established Space Research Institute (SRI) serves as the central hub connecting the broad range of space-related research across campus. Led by Jud Ready, who also serves as principal research engineer at the Georgia Tech Research Institute, SRI has expanded support for space research and commercialization through initiatives such as the CreationsVC Space Fellows Program and Centers, Programs, and Initiatives seed grant program.

SRI’s efforts are in line with Georgia Tech’s long-standing contribution to space exploration. Hundreds of Yellow Jacket alumni work in the space sector, including several graduates who are playing key roles in the Artemis program. To date, more than a dozen Georgia Tech alumni have traveled to space.

Exploring the Final Frontier

The conference featured a series of panels and discussions led by faculty and researchers from the Colleges of Sciences and Engineering as well as the Ivan Allen College of Liberal Arts. 

Sessions explored how researchers are studying the processes and conditions that support planetary habitability, seeking to answer one of humanity’s greatest questions: Does life exist beyond Earth? Speakers also examined how analog fieldwork in Earth’s extreme environments can inform space exploration, and how space research, in turn, can deepen our understanding of our own world.

Additional conversations centered on building better space missions through improved understanding of team and individual resilience, data collection, navigation, and the development of advanced technologies like the robots developed through the NASA LASSIE Project. 

Frontiers also highlighted Georgia Tech’s commitment to preparing the next generation of space scientists, engineers, and leaders. Student training and engagement were recurring themes throughout the day, with speakers emphasizing opportunities for student-led and student-run missions and research. A panel of Georgia Tech alumni shared their own STEM career journeys, challenging the idea of “one right path” to success — and acknowledging the resources and opportunities available at the Institute. 

A highlight of the conference was a fireside chat with Atlanta-native, retired U.S. Army Colonel and NASA Astronaut R. Shane Kimbrough (M.S. Operations Research 1998). Kimbrough, who spent a total of 388 days in space and performed nine spacewalks across three missions, reflected on his career and the evolution of spaceflight. He emphasized the expanding role of public-private and international partnerships in advancing ambitious goals, such as creating a permanent human outpost on the Moon. 

Policy and Public

The conference also explored how policy influences space discovery and innovation, with discussions touching on such issues as space security, access, governance, sustainability — and the influence of technology and science fiction on public perception and policy. 

Panelists described current policy frameworks governing outer space as struggling to keep pace with rapidly advancing technologies and expanding activities. According to these experts, increasing tensions among commercial, research, and recreational uses of space call for greater coordination among private and government entities to balance competing priorities while maximizing opportunities for innovation and exploration. 

The conference was punctuated by a networking lunch connecting attendees with Atlanta’s public astronomy community – including partners at several universities and the Georgia Tech Astronomy Club, which set up telescopes for attendees to safely observe the sun. Later that evening, the Georgia Tech Observatory hosted its Public Night, welcoming the broader Atlanta community to campus for telescope views of Jupiter, the Orion Nebula, and other celestial bodies. 

The Observatory Night was a fitting conclusion to a full day focused on Georgia Tech’s commitment and contributions to inspiring future generations of space explorers through research, education, and outreach. 

Experience the Frontiers conference in pictures on the College of Sciences’ Flickr account.

Rising oil and gasoline prices have been the center of attention since the closure of the Strait of Hormuz. But that immediate effect tells only part of the story. Because oil and gas underpin production, transportation, and logistics, higher energy costs will gradually move through supply chains — meaning the most significant economic consequences may not appear for months. 

“The effects move slowly and appear in places people do not connect to energy,” said Tibor Besedes, professor in the School of Economics. “Oil and natural gas are part of the cost structure for an enormous range of goods.”

About 20% of global oil and liquefied natural gas flows through the waterway linking the Persian Gulf to world markets. When that flow is constrained, the impact ripples outward across industries most people never associate with an energy crisis.

“In complex supply chains, a disruption in one critical link, even if only briefly, can cascade through the system, well beyond the initial event,” says Pinar Keskinocak, chair and professor in the H. Milton Stewart School of Industrial and Systems Engineering. “As delays persist and compound, interconnected systems often take a long time to recover, rebalance, and return to normal.”

Price Pressures That Arrive Quietly

Early effects are already visible. 

Jet fuel availability is tightening, and diesel prices are rising across Asia. China has ordered refineries to stop exporting fuel, creating shortages that are increasing shipping costs for U.S. imports, from consumer electronics to pharmaceuticals.

The strait is also a key corridor for naphtha, a feedstock used to produce plastics, packaging, solvents, textiles, and pharmaceutical components. Roughly 85% of Middle Eastern polyethylene exports move through the strait. 

“Consumers won't see the effect of this quickly,” Besedes says, “but the longer the strait is closed, the higher the cost will be of all of these products naphtha is used for.”

Aluminum is equally exposed. 

“Smelters require sustained, low-cost energy,” said Chris Gaffney, a professor of the practice in the Stewart School. “The Middle East accounted for roughly 21% of U.S. unwrought aluminum imports in 2025. When energy prices spike or supply is constrained, capacity is reduced or shut down, and those decisions are difficult and slow to reverse.”

Fertilizer is one of the clearest examples of delayed inflation. Natural gas is essential for its production, and Persian Gulf states account for one-third of global urea exports and half of global sulfur exports. Urea prices at the New Orleans import hub have already climbed sharply.

“We won't see the effects quickly, but rather in six to 12 months, depending on the crop and its cycle,” Besedes says. “Without or with less fertilizer, crop yields will decrease, resulting in higher prices.”

Why Hormuz Is Different From Other Chokepoints

On top of all those factors, the strait closure presents a uniquely dangerous vulnerability. 

“Unlike a port strike or canal blockage, there is no meaningful way to reroute volume,” says Gaffney. “If it is disrupted, flow is constrained rather than redirected.” Pipeline alternatives replace only a fraction of the 20 million barrels per day that normally transit the strait.

“Choke point vulnerability arises when a large portion of flow depends on a route that is hard to substitute,” said Mathieu Dahan, associate professor in the Stewart School. “Hormuz has no scalable alternatives with sufficient capacity.” 

Alan Erera, senior associate chair in the Stewart School expanded on Dahan’s point, noting that strait disruptions raise costs across manufacturing and distribution.

“Ships are rerouted onto longer paths, which drives up fuel and labor costs, ties up vessels and containers for longer periods, and ultimately raises inventory costs for shippers because capital is locked up while goods are still in transit,” Erera said.

When Geopolitics Meets Global Supply Chains

Additionally, the strait closure raises the risk of wartime miscalculation. 

“We haven’t seen a disruption on this scale since the tanker wars of the late 1980s,” said Larry Rubin, associate professor in the Sam Nunn School of International Affairs. Gulf states' dependence on the strait constrains both regional actors and U.S. strategy, raising risks around crisis decision-making.

Rubin also points to a dimension most coverage has missed entirely. “One thing that has been overlooked by many commentators is the fact that the Iranian people have probably been hit the hardest economically,” he says. “They were already in a challenging situation. The Iranian economy won't recover quickly after the war.”

Resilience Has a Short Memory

Meanwhile, for the United States, “The Strategic Petroleum Reserve provides a buffer, and domestic energy production has improved resilience,” says Gaffney. “But the gap remains between enabling capacity and sustaining resilience. Policy can support infrastructure, but it cannot ensure private sector participants invest in resilience when cost pressures rise.”

For policymakers and industry leaders, the disruption reinforces a familiar pattern. "The supply chain remains optimized for efficiency rather than resilience, in part due to the high investment costs required to build flexibility," says Dahan. 

Gaffney added that resilience does improve after disruption, but that “it erodes over time if not actively maintained.”

Even if the strait reopens, higher costs and slow restart timelines mean the system will not snap back. Experts suggest that when headlines have moved on from this disruption, it will still be shaping prices across the economy. 

Institute Communications

As students increasingly turn to artificial intelligence (AI) to help with coursework, some worry that their learning could be compromised. Georgia Tech researchers are working to counter this potential decline with an AI tool they hope will promote learning rather than hinder it.  

TokenSmith is a citation-supported large language model (LLM) tutor that can be hosted locally on a user’s personal computer. The tutor only provides answers based on course materials, such as the textbook or lecture slides.  

Associate Professor Joy Arulraj began the project with support from the Bill Kent Family Foundation AI in Higher Education Faculty Fellowship last year. The fellowship, led by Georgia Tech’s Center for 21st Century Universities, supports faculty projects exploring innovative and ethical uses of AI in teaching.   

Arulraj has enlisted assistant professors Kexin Rong and Steve Mussmann to help build TokenSmith.  

Mussmann said TokenSmith is a synergistic blend of a database system and a machine learning system. The model stores textbooks, textbook annotations by course staff, common questions and answers, a learning state of the student, and student feedback in a structured database system. However, machine learning plays a key role in the answer generation as well as adapting the system to the student, course staff guidance, and user feedback.

"What excites me most is demonstrating how data-driven ML and principled database systems design can reinforce each other — one providing adaptability and flexibility, the other providing structure and traceability — in a way that benefits students," Mussmann said.

Keeping the model local has been an important focus of the project. The team wanted to create an AI tutor that helps students learn from their class resources rather than just giving answers. With each response, TokenSmith cites the origin of the answer in the provided documents.  

“One problem with LLMs is that they can hallucinate and provide wrong answers, but in this controlled environment, we can add these guardrails to make sure it’s actually helpful in an educational setting,” Rong said.  

Rong said she feels that students often undervalue textbooks, and she hopes TokenSmith can motivate students to make better use of them.  

“Textbooks can sometimes be daunting, but maybe if we combine them with the model, students might be more willing to read a paragraph or page in the textbook, and that could help clarify something for them,” she said.  

Running the model locally is more cost-effective and helps preserve the user’s privacy. But running the new tool locally comes with technical challenges.  

One challenge with creating the model is speed. Since it is a locally based model, TokenSmith depends solely on the user’s computer memory.  Tests have also shown that the tutor currently struggles to answer more complex questions. 

“We are interested in pushing the boundaries of these local models so that they give students good answers and also run fast enough to keep students engaged,” Arulraj said.  

The United States continues to face deadly infectious disease outbreaks, from emerging viruses to antibiotic-resistant bacteria, underscoring the nation’s need for rapid, effective response systems. These threats extend beyond public health, disrupting daily life, straining health care systems, and impacting military readiness.

A team of researchers led by Ankur Singh, the Carl Ring Family Professor in the George W. Woodruff School of Mechanical Engineering and professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, has been awarded up to $6 million from the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defense to accelerate the development of medical countermeasures (MCMs) against deadly biological threats that endanger public health, national security, and warfighters.

DTRA’s mission is to provide solutions that enable the Department of Defense, the U.S. government, and international partners to deter strategic threats. A key priority is advancing new or improved MCMs that can be deployed before or after exposure to biological or chemical agents.

Singh’s multi-year project, Systematic Human Immune Engineering for Lethal Disease (SHIELD) Countermeasures, aims to create a threat-agnostic platform that transforms how respiratory pathogens and toxins are studied. The platform is designed to speed up the discovery, development, and production of immune-based countermeasures.

Singh leads a collaborative team that includes Cornell University’s Matthew DeLisa and Stanford University’s Michael Jewett. Together, they will integrate immune-engineering technologies with advanced cell-free protein synthesis platforms to discover and manufacture protein-based MCMs. Cell-free protein synthesis is a laboratory technique that efficiently produces proteins without relying on living cells, which can be unpredictable and technically demanding when it comes to expressing complex or toxic proteins and scaling production quickly. The team expects the SHIELD Countermeasures platform to reduce the time and cost of MCM development by more than tenfold.

“The foundational science and cutting-edge tools we develop will ignite future discoveries, ensuring a robust pipeline of advanced protein-based MCMs for chemical and biological defense,” said Singh, who also directs the Center for Immunoengineering at Georgia Tech. “This will significantly enhance national security and equip our warfighters with next-generation biodefense capabilities."

Traditional animal models often fail to accurately replicate human immune responses, and standard tissue cultures lack the complexity required to study how immune cells interact with pathogens. In contrast, human immune organoids and immune-competent devices — built from human cells — are emerging as groundbreaking research tools. These systems recreate key immune features, such as lymph nodes and mucosal environments, within three-dimensional or microengineered platforms.

“Many organoid and engineering devices, often called organ-on-chip platforms, lack immune integration,” Singh said. “Because immunity sits at the center of human health, these limitations have broad consequences. Immune-competent organ-on-chip platforms extend this concept by combining human cells with microfluidic engineering that simulates blood flow, tissue barriers, and chemical gradients.”

Singh has previously published studies on a synthetic human immune chip and an immunocompetent lung on a chip, and has also teamed up with DeLisa previously to use synthetic immune organoids for immuno-profiling antibacterial MCMs.

“It’s about being able to test far larger numbers of candidate protein-based MCMs in a single experiment—and to do it much faster,” DeLisa said. “Cell-free systems allow us to produce MCMs at unprecedented speed and scale, but traditional evaluation methods can’t keep up with those numbers. By combining cell-free MCM production with immune organoid technology, we can assess the potency of dozens or even hundreds of candidates at a time and characterize the resulting immune responses within just a few days.”

By integrating immune cells with tissues such as lung, gut, skin, or vascular systems, these devices allow scientists to observe immune responses in real time, including cell migration, inflammation, and interactions with pathogens or therapeutics. As biological threats evolve, the development and deployment of immune-competent platforms will be critical for rapid, effective countermeasures.

DTRA’s investment in Singh’s work highlights the urgent national priority of strengthening U.S. biodefense capabilities. The SHIELD Countermeasures platform and its cutting-edge technologies promise to transform the nation’s response to biological threats and help safeguard communities from biological and chemical attacks.

In recent years, the Centers for Disease Control and Prevention, the Department of Homeland Security, and other authorities have flagged a record number of unauthorized shipments of biological materials. At the same time, global intelligence communities have identified numerous attempts to smuggle sensitive biological samples in efforts of industrial theft or espionage. 

“A small vial of genetically engineered cells can contain multiple millions of dollars’ worth of intellectual property and require several years of work to develop,” said Corey Wilson, a professor in Georgia Tech’s School of Chemical and Biomolecular Engineering (ChBE). “Accordingly, the protection of high-value engineered cell lines has become critically important to the biotechnology industry.”

Wilson and his research team have published their findings in Science Advances demonstrating the effectiveness of their new biological security technology, known as GeneLock™, in protecting high-value engineered cell lines.

GeneLock is a cybersecurity-inspired technology that protects valuable genetic material directly at the DNA level. To demonstrate its strength, Wilson’s team conducted what they describe as a first-of-its-kind biohackathon, detailed in the new paper, to simulate unauthorized access. 

“GeneLock greatly improves our ability to protect high-value engineered cell lines by expanding security from the lab environment to the genetic level,” Wilson said.

Economic Impact

What are the stakes? Estimates place the global market for high-value genetic materials at more than $1.5 trillion, projected to reach $8 trillion by 2035. The use of these materials ranges from advanced medicines and proprietary research enzymes to specialty chemicals and sustainable materials.

Currently, the protection of high-value cell lines depends on physical safeguards such as restricted lab access and secure facilities, Wilson explained.

“The key weakness of physical security measures is once circumvented, there are typically no measures in place to protect valuable cells from theft, abuse, or unauthorized use,” Wilson said. 

“Once a sample leaves the building, the DNA it carries typically remains fully functional. This is like placing an unlocked cellphone in a desk drawer. Anyone who gains access to the drawer can view sensitive content on the phone­­­­­­­—or in this case will have full access to the valuable cell line.”

Genetic Passcode Protection

The GeneLock biological security technology developed by Wilson and his team places a passcode on engineered cells, akin to those used on ATM machines and protected cellphones.

Instead of leaving a valuable gene in readable form, the team scrambles the DNA sequence of interest. The scrambled genetic asset remains in a nonfunctional state unless the living cell where it resides receives the correct sequence of chemical inputs. Those inputs act as a molecular passcode.

“Only the right combination, delivered in the right order, rearranges the DNA into a working form,” Wilson said.

Biohackathon Security Test

To evaluate the technology, the researchers organized a blue team and a red team in what they describe as an ethical biohackathon. The blue team designed the encrypted DNA sequence, while the red team was challenged to discover the correct chemical passcode through experimentation in a gray box exercise, meaning the red team had partial knowledge of the system but did not have access to the internal designs. 

“This approach for testing security strength is commonly used in cybersecurity,” Wilson explained. 

The blue team engineered the system inside Escherichia coli, or E. coli, a bacterium widely used in biotechnology. The protected asset was a fluorescent protein gene selected as a measurable stand-in for commercially valuable targets. When the correct chemical sequence was applied, the fluorescence turned on. Without the correct passcode, the gene remained scrambled and the cells could not fluoresce green. 

“In practice, most DNA sequences produce valuable proteins or chemicals that are essentially invisible to the human eye, requiring specialized devices or experiments to observe,” Wilson said. “If the biohackathon were conducted with a standard commercially valuable target, the penetration testing would have taken more than 10 times longer to complete, years instead of months.”

The biohackathon results showed a dramatic reduction in risk. GeneLock reduced the probability of unlocking the genetic asset by random search to about 1 in 85,000 (a 0.001% chance), assuming the unauthorized user had access to the required chemical inputs.

Without access to those inputs, “the likelihood of success by chance becomes effectively negligible,” said Dowan Kim (Georgia Tech PhD 2024), co-lead author of the study.

Commercial Uses and What’s Next 

Although the researchers used a non-commercial fluorescent protein as a test case, the implications extend much further. Many biotechnology companies rely on proprietary engineered strains. New England Biolabs, for example, produces more than 265 non-disclosed enzymes in E. coli, each representing a high-value cell line. 

Protein-based drugs are also manufactured in living cells, and proprietary metabolic pathways are used to produce specialty chemicals, bioplastics, and high-value ingredients. 

“In each case, the genetic blueprint inside the cell represents intellectual property that can be protected by our technology,” said Ishita Kumar, a PhD candidate in ChBE and co-lead author of the study.

While the team’s current focus is on protecting intellectual property in the form of high-value cells, future iterations aim to strengthen biological security more broadly. 

“We are currently developing protection measures to mitigate unauthorized use or release of sensitive cell lines that can be potentially hazardous to human health or the environment,” Wilson said.

“As it stands, GeneLock represents an important shift in biological security, enabling, for the first time, protection of valuable cells at the genetic level, even after physical security measures have been bypassed,” he added. 

The work is already moving toward commercialization. The team filed a provisional patent application with the U.S. Patent and Trademark Office in February 2026 and is forming a company to deploy the technology.

This research was funded by a grant from the National Science Foundation.

CITATION:

Dowan Kim, Ishita Kumar, Mohamed Hassan, Luisa F. Barraza-Vergara, Christopher A. Voigt, and Corey J. Wilson, “Protecting cells at the genetic level and simulating unauthorized access via a biohackathon,” Science Advances, 2026.

Manufacturing is undergoing a significant transformation as artificial intelligence reshapes how industrial systems operate, adapt, and scale. The H. Milton Stewart School of Industrial and Systems Engineering (ISyE) has launched its Manufacturing and AI Initiative, which brings together faculty expertise in statistics, optimization, data science, and systems engineering to address emerging challenges and opportunities in modern manufacturing.

ISyE researchers are applying AI to complex manufacturing environments, including multistage production systems, asset management, quality improvement, and human‑centered manufacturing. Faculty leaders emphasize the importance of contextualizing large volumes of manufacturing data so AI can support reliable decision‑making, efficient operations, and sustainable outcomes. At the same time, the initiative acknowledges challenges such as data integration, system complexity, and the need to balance automation with human involvement. Together, these efforts position ISyE at the forefront of shaping AI‑powered manufacturing systems that are innovative, resilient, and socially responsible.

Read the full article in ISyE Magazine 

A recent review by EPIcenter faculty affiliate Constance Crozier (School of Industrial and Systems Engineering, Georgia Institute of Technology) and Matthew Liska (School of Physics, Georgia Institute of Technology) explores the growing role of data centers in providing flexibility, the ability to shift or reduce electricity use in response to grid conditions, to the electric grid as renewable energy penetration and AI-driven computing demand surge. The authors highlight that data centers, particularly those supporting high-performance computing and AI workloads, are projected to consume nearly 10% of U.S. electricity by the end of the decade, presenting both challenges and opportunities for grid stability.

The paper examines various strategies for enhancing the flexibility of data center energy use. One approach is to use backup power systems, such as uninterruptible power supplies, to support the grid during emergencies. Another method involves rerouting computing jobs to different data centers in other locations to balance energy demand. The authors also discuss implementing smart scheduling techniques that shift workloads to off-peak hours, reducing strain on the grid. Additionally, they highlight adjusting processor speeds by lowering CPU (central processing unit) and GPU (graphics processing unit) clock rates to limit power consumption when needed. Finally, the paper suggests pre-cooling data center equipment to limit the energy required for cooling during peak demand periods. Notably, experimental evidence shows that underclocking GPUs can cut power consumption by 40% with only a 22% performance loss, suggesting technical feasibility for demand-response interventions.

Despite these technical options, the authors find that real-world cost considerations and reliability concerns limit widespread adoption. Data center operators generally do not change their behavior in response to electricity prices, as job revenue far outweighs energy costs under normal conditions. For example, a GPU rented at $2 per hour consumes only $0.04 worth of electricity at average prices, making curtailment unattractive except during extreme price spikes. Surveys indicate that operators are reluctant to compromise reliability or deploy backup systems for ancillary services. Consequently, price-based incentives alone are unlikely to drive meaningful flexibility.

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