Jan. 07, 2025
Historical sign depicting information about Tech Tower

Georgia Tech’s Executive Vice President for Research search committee has selected three finalists. Each candidate will visit campus and present a seminar sharing their broad vision for the Institute's research enterprise. The seminars are open to all faculty, students, and staff across the campus community. Interested individuals can attend in person or register to participate via Zoom (pre-registration is required).    

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Jan. 07, 2025
Historical sign depicting information about Tech Tower

Georgia Tech’s Executive Vice President for Research search committee has selected three finalists. Each candidate will visit campus and present a seminar sharing their broad vision for the Institute's research enterprise. 

The seminars are open to all faculty, students, and staff across the campus community. Interested individuals can attend in person or register to participate via Zoom (pre-registration is required).    

All seminars will take place at 11 a.m. on the following dates:  

  • Candidate 1: Monday, January 13, Scholars Event Theater, Price Gilbert 1280 (register for webinar)  
  • Candidate 2: Tuesday, January 21, Bill Moore Student Success Center, Press Rooms A&B (register for webinar)  
  • Candidate 3: Monday, January 27, Scholars Event Theater, Price Gilbert 1280 (register for webinar)  

Each candidate’s bio and curriculum vitae, along with further details, will be accessible through the EVPR search site 48 hours prior to each visit. Georgia Tech credentials are required to access all materials. Information is being made available in this manner to protect the confidentiality of the finalists. Following each candidate’s visit, is the campus community is invited to share their comments via a survey that will be posted on the candidate’s webpage   

The search committee is chaired by Susan Lozier, dean of the College of Sciences. Search committee members include a mix of faculty and staff representing colleges and units across campus. Georgia Tech has retained the services of the executive search firm WittKieffer for the search.  

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Shelley Wunder-Smith | shelley.wunder-smith@research.gatech.edu
Director of Research Communications
 

Jan. 07, 2025
Omer Inan holds an early prototype of Arthroba.

Samer Mabrouk and Omer Inan have been working on a wearable, battery-powered device that monitors joint health and gives personalized strengthening exercises. Inan and Mabrouk’s new company, Arthroba, created a device of the same name that uses electrical sensors to track swelling and tissue damage in the knee, ankle, and other critical joints.

Jan. 06, 2025
David Sherrill, professor in the School of Chemistry and Biochemistry and School of Computational Science and Engineering; associate director of the Georgia Tech Institute for Data Engineering and Science.

Effective January 1st, David Sherrill will serve as interim executive director of the Georgia Tech Institute for Data Engineering and Science (IDEaS). Sherrill is a Regents' Professor in the School of Chemistry and Biochemistry with a joint appointment in the College of Computing. Sherrill has served as associate director for IDEaS since its founding in 2016.

"David Sherrill's leadership role in IDEaS as associate director, together with his interdisciplinary background in chemistry and computer science, makes him the right person to support this transition as interim executive director," said Julia Kubanek, professor and vice president for interdisciplinary research at Georgia Tech. 

Sherrill succeeds Srinivas Aluru who will be taking a new position as Senior Associate Dean in the College of Computing. Aluru, a Regents' Professor in the School of Computational Science and Engineering, co-founded IDEaS and served as its co-executive director (2016-2019) and then as executive director (2019-date), spanning eight and a half years. Under his leadership IDEaS grew to more than 200 affiliate faculty spanning all colleges, encompassing multiple state, federal, and industry funded centers. Notable among these is the South Big Data Hub, catalyzing the Southern data science community to collectively accelerate scientific discovery and innovation, spur economic development in the region, broaden participation and diversity in data science, and the CloudHub, a Microsoft funded center that provides research funding and cloud resources for innovative applications in Generative Artificial Intelligence. More recently, Aluru established the Center for Artificial Intelligence in Science and Engineering (ARTISAN), and expanded the Institute’s research staff to provide needed cyberinfrastructure, software resources, and expertise to support faculty projects with large data sets and AI-driven discovery. "I've had the pleasure of serving as Associate Director of IDEaS since it was founded by Srinivas Aluru and Dana Randall, and I'm excited to step into this interim role.” said Sherrill. “IDEaS has an important mission to serve the many faculty doing interdisciplinary research involving data science and high performance computing."

Sherrill’s research group focuses on the development of ab initio electronic structure theory and its application to problems of broad chemical interest, including the influence of non-covalent interactions in drug binding, biomolecular structure, organic crystals, and organocatalytic transition states. The group seeks to apply the most accurate quantum models possible for a given problem and specializes in generating high-quality datasets for testing new methods or machine-learning purposes. 

Sherrill earned a B.S. in chemistry from MIT in 1992 and a Ph.D. in chemistry from the University of Georgia in 1996. From 1996-1999 Sherril was an NSF Postdoctoral Fellow, working under M. Head-Gordon, at the University of California, Berkeley.

Sherrill is a Fellow of the American Association for the Advancement of Science (AAAS), the American Chemical Society, and the American Physical Society, and he has been Associate Editor of the Journal of Chemical Physics since 2009. Sherrill has received a Camille and Henry Dreyfus New Faculty Award, the International Journal of Quantum Chemistry Young Investigator Award, an NSF CAREER Award, and Georgia Tech's W. Howard Ector Outstanding Teacher Award. In 2023, he received the Herty Medal from the Georgia Section of the American Chemical Society, and in 2024, he was elected to the International Academy of Quantum Molecular Science.

--Christa M. Ernst

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Christa M. Ernst [christa.ernst@research.gatech.edu],


Research Communications Program Manager,


Topic Expertise: Robotics | Data Sciences| Semiconductor Design & Fab

 

Dec. 21, 2024
Lipid nanoparticle AI generated image from adobe stock

Lipid nanoparticles in their element: This computer generated image shows lipid nanoparticles, which are used to transport payloads to targets inside the body.

Middlemen get a bad rap for adding cost and complications to an operation. So, eliminating the go-betweens can reduce expense and simplify a process, increasing efficiency and consumer happiness. 

James Dahlman and his research team have been thinking along those same lines for stem cell treatments. They’ve created a technique that eliminates noisome middlemen and could lead to new, less-invasive treatments for blood disorders and genetic diseases. It sidesteps the discomfort and risks of current treatments, making life easier for patients.

“This would be an alternative to invasive hematopoietic stem cell therapies — we could just give you an IV drip,” said Dahlman, McCamish Early Career Professor in the Wallace H. Coulter Department of Biomedical Engineering. “It simplifies the process and reduces the risks to patients. That’s why this work is important.”

Dahlman and a team of investigators from Georgia Tech, Emory University, and the University of California, Davis, published their approach in the journal Nature Biotechnology.

Minding the Parents

Hematopoietic stem cells (HSCs) are like parent cells. Residing in the bone marrow, they produce all types of cells needed to sustain the blood and immune systems. Their versatility makes HSCs a valuable therapeutic tool in treating genetic blood diseases, such as sickle cell anemia, immune deficiencies, and some cancers. 

HSC therapies usually involve extracting cells from the patient’s bone marrow and re-engineering them in a lab. Meanwhile, the patient endures chemotherapy to help prepare their body to receive the modified HSCs.

“These therapies are effective but also hard on the patients,” Dahlman said. “Patients undergo chemotherapy to wipe out their immune systems so the body will accept the therapeutic cells without a fight. The procedure can be life-threatening. We’re hoping to change that.”

HSCs can also be modified directly inside the body. The procedure uses lipid nanoparticles (LNPs) to carry genetic instructions to the stem cells. The LNPs have targeting ligands attached — molecules designed to find specific target cells. Precisely engineering them adds layers of time, complexity, and cost to the process. They are, like extraction from bone marrow and chemotherapy, another middleman.

The researchers wanted something simpler. They found it in a specific nanoparticle called LNP67.

“Unlike other nanoparticle designs, this one doesn’t require a targeting ligand,” Dahlman said. “It’s chemically simple, which means it’s easier to manufacture and opens the door to eventually scaling production, like mRNA vaccines.”

Overcoming the Liver

The key to LNP67’s success is its ability to dodge the liver, the body’s primary blood filter. Foreign invaders, even helpful invaders delivered through an IV as medicine, can be captured by a healthy liver. 

“The liver absorbs almost everything,” Dahlman said. “But, by reducing what it captures by even as little as 10 percent, we can double delivery to other tissues where the nanoparticles and their payloads are needed.”

The researchers developed 128 unique nanoparticles, narrowing the list down to 105 LNPs that didn’t have targeting ligands. These were ultimately screened and evaluated for their performance in delivering genetic instructions (in the form of mRNA) effectively and safely. 

LNP67 emerged as the best performer thanks to its stealthy design. For example, the surface is designed to repel proteins and other molecules that would mark the LNP for capture by the liver. This feature helped the particles circulate more evenly in the body and reach the HSCs.

“We achieved low-dose delivery without a target ligand, which is exciting,” Dahlman said. “This is something we’ve been working toward for years, and I’m very happy we got there.”

Citation: Hyejin Kim, Ryan Zenhausern, Kara Gentry, Liming Lian, Sebastian G. Huayamares, Afsane Radmand, David Loughrey, Ananda Podilapu, Marine Z. C. Hatit, Huanzhen Ni, Andrea Li, Aram Shajii, Hannah E. Peck, Keyi Han, Xuanwen Hua, Shu Jia, Michele Martinez, Charles Lee, Philip J. Santangelo, Alice Tarantal, James E. Dahlman. Lipid Nanoparticle Study, Nov. 2024, Nature Biotechnology.

Funding: This research was supported by the National Institutes of Health grants UL1TR002378, UH3-TR002855, U42 OD027094, and TL1DK136047; National Science Foundation grant 0923395. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of any funding agency.

Competing Interests: James Dahlman, Marine Z. C. Hatit, and Huanzhen Ni have filed a provisional patent related to this manuscript (US patent application number 63/632,354). 

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Dec. 18, 2024
Lipids can be powerful tools to help deliver drugs and treatments through their interactions with proteins. (Adobe Stock)

Lipids can be powerful tools to help deliver drugs and treatments through their interactions with proteins. (Adobe Stock)

From combating cancer and infections to storing energy, lipid-protein interactions are critical to biological processes in cells. But the mechanisms that drive these interactions have historically been difficult to map and understand.

A study led by Georgia Tech is showcasing a new resource to help researchers understand the structure and function of these interactions — called assemblies — at both molecular and functional levels. The work is published in the Nature-family journal Communications Chemistry.

Called BioDolphin — short for Biological Database of Lipid-Protein Highly Inclusive Interactions — the resource is the first comprehensive, annotated database of protein-lipid interactions. Integrated into a user-friendly web server, BioDolphin is freely accessible to all. Users can easily view and download interaction data and systematically analyze lipid-protein assemblies.

“Understanding lipid-protein interactions is crucial in advancing our understanding of human health and disease treatment,” says the study’s corresponding author, Andrew McShan. “BioDolphin is the first resource to collect this type of information for all kinds of proteins, not just those found in membranes. And because it is publicly available, this information is now at the tips of researchers’ fingertips.”

“BioDolphin as a comprehensive database of lipid–protein binding interactions” is led by McShan, an assistant professor in the School of Chemistry and Biochemistry at Georgia Tech, alongside first author Li-Yen (Zoey) Yang, Bioinformatics Ph.D. student; School of Computational Science and Engineering Assistant Professor Yunan Luo; and Kaike Ping, a Ph.D. student at Virginia Tech.

Diving into accessible data

A curated database with richly annotated information, BioDolphin contains over 127,000 lipid-protein binding interactions. And while most databases of lipid-protein assemblies have focused solely on a specific type of protein — membrane proteins — BioDolphin expands beyond that.

“BioDolphin enables us to globally define the structural features of lipid-protein assemblies across the eight different classes of lipid compounds to understand their cellular function and roles in disease,” says McShan, adding that the database also provides information on paired lipid-protein annotation, experimental binding affinities, intermolecular interactions, and atomic structures across a wide range of lipid-protein interactions — all available to anyone with an internet connection.

A molecular blueprint for research — and teaching

“In the past, this research has been limited because lipids are notoriously difficult to study in the lab,” McShan says. "BioDolphin changes the paradigm. It is the first time that anyone has collected, annotated, and analyzed the known structural universe of lipid-protein interactions across all organisms.”

It’s a rapidly developing field. McShan was recently awarded a prestigious Curci grant for cutting-edge cancer research into lipid-based universal immunotherapies and vaccines.

Beyond research applications, the team hopes that BioDolphin will be a resource for biochemistry students. 

“The database can serve as a tool for teachers and students studying these protein-lipid interactions, which is often an underdeveloped topic in biology and biochemistry courses,” McShan says. “I hope that BioDolphin is a valuable resource for the researchers of today — and that it can also be a building block for the researchers of tomorrow.”

Funding: Shurl and Kay Curci Foundation, NSF Advanced Cyberinfrastructure Coordination Ecosystem: Services & Support (ACCESS) program, NIH National Institute of General Medical Sciences (NIGMS), Partnership for an Advanced Computing Environment (PACE) at the Georgia Institute of Technology, and Taiwan Ministry of Education Government Scholarship to Study Abroad program.

DOI: https://doi.org/10.1038/s42004-024-01384-z 

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Dec. 16, 2024
 The International Space Station orbits Earth. NASA/Roscosmos

The International Space Station orbits Earth. NASA/Roscosmos

Flying through Earth’s orbit are thousands of satellites and two operational space stations, including the International Space Station, which weighs as much as 77 elephants. The International Space Station, or ISS, hosts scientists and researchers from around the world as they contribute to discoveries in medicine, microbiology, Earth and space science, and more.

One of my first jobs in aerospace engineering was working on the ISS, and the ISS remains one of my favorite aerospace systems. I now work at Georgia Tech, where I teach aerospace engineering.

The ISS travels very quickly around the Earth at 5 miles per second (8 kilometers per second), which means it could fly from Atlanta to London in 14 minutes. But at the same time, small chunks of rock called meteoroids shoot through space and burn up when they hit Earth’s atmosphere. How is it that some objects – such as the International Space Station – orbit the Earth unscathed, while others, such as asteroids, burn up?

To answer why the ISS can stay in orbit for decades unscathed, you first need to understand why some things, such as meteoroids, do burn up when they enter our planet’s atmosphere.

Why Do Meteoroids Burn Up in the Atmosphere?

Meteoroids are small chunks of rock and metal that orbit the Sun. These space rocks can travel between 7 and 25 miles per second (12 to 40 km per second). That’s fast enough to cross the entire United States in about 5 minutes.

Sometimes, the orbit of a meteoroid overlaps with Earth, and the meteoroid enters Earth’s atmosphere – where it burns up and disintegrates.

Even though you can’t see them, the atmosphere is full of a combination of particles, primarily nitrogen and oxygen, which make up the air you breathe. The farther you are from the surface of the Earth, the lower the density of particles in the atmosphere.

The atmosphere has several layers. When something from space enters the Earth’s atmosphere, it must pass through each of these layers before it reaches the ground.

Meteoroids burn up in a part of Earth’s atmosphere called the mesosphere, which is 30 to 50 miles (48 to 80 kilometers) above the ground. Even though the air is thin up there, meteoroids still bump into air particles as they fly through.

When meteoroids zoom through the atmosphere at these very high speeds, they are destroyed by a process that causes them to heat up and break apart. The meteoroid pushes the air particles together, kind of like how a bulldozer pushes dirt. This process creates a lot of pressure and heat. The air particles hit the meteoroid at hypersonic speeds – much faster than the speed of sound – causing atoms to break away and form cracks in the meteroid.

The high pressure and hot air get into the cracks, making the meteoroid break apart and burn up as it falls through the sky. This process is called meteoroid ablation and is what you are actually seeing when you witness a “shooting star.”

Why Doesn’t the Space Station Burn Up?

So why doesn’t this happen to the International Space Station?

The ISS does not fly in the mesosphere. Instead, the ISS flies in a higher and much less dense layer of the atmosphere called the thermosphere, which extends from 50 miles (80 km) to 440 miles (708 km) above Earth.

The Kármán line, which is considered the boundary of space, is in the thermosphere, 62 miles (100 kilometers) above the surface of the Earth. The space station flies even higher, at about 250 miles (402 km) above the surface.

The thermosphere has too few particles to transmit heat. At the height of the space station, the atmosphere is so thin that to collect enough particles to equal the mass of just one apple, you would need a box the size of Lake Superior!

As a result, the ISS doesn’t experience the same kind of interactions with atmospheric particles, nor the high pressure and heat that meteoroids traveling closer to Earth do, so it doesn’t burn up.

A High-Flying Research Hub

Although the ISS doesn’t burn up, it does experience large temperature swings. As it orbits Earth, it is alternately exposed to direct sunlight and darkness. Temperatures can reach 250 degrees Fahrenheit (121 degrees Celsius) when it’s exposed to the Sun, and then they can drop to as low as -250 degrees F (-156 degrees Celsius) when it’s in the dark – a swing of 500 degrees F (277 degrees C) as it moves through orbit.

The engineers who designed the station carefully selected materials that can handle these temperature swings. The inside of the space station is kept at comfortable temperatures for the astronauts, the same way people on Earth heat and cool our homes to stay comfortable indoors.

Research on the ISS has led to advancements such as improved water filtration technologies, a better understanding of Earth’s water and energy cycles, techniques to grow food in space, insights into black holes, a better understanding of how the human body changes during long-duration space travel, and new studies on a variety of diseases and treatments.

NASA plans to keep the ISS active until 2030, when all of the astronauts will return to Earth and the ISS will be deorbited, or brought down from orbit by a specially designed spacecraft.

As it comes down through Earth’s atmosphere in the deorbiting process, it will enter the mesosphere, where many parts of it will heat up and disintegrate.

Some spacecraft, such as the crew capsules that bring astronauts to and from the ISS, can survive reentry into the atmosphere using their heat shield. That’s a special layer made up of materials that are able to withstand very high temperatures. The ISS wasn’t designed for that, so it doesn’t have a heat shield.

If you’d like to see the space station as it passes over your area, you can check out NASA’s website to find out when it might be visible near you.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Author:

Kelly Griendling, Lecturer of Aerospace Engineering, Georgia Institute of Technology

 
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Shelley Wunder-Smith
shelley.wunder-smith@research.gatech.edu

Dec. 16, 2024
 The Ruta N partnership in Medellín, Colombia, generated thousands of jobs. Jorge Calle/Anadolu Agency via Getty Images

The Ruta N partnership in Medellín, Colombia, generated thousands of jobs. Jorge Calle/Anadolu Agency via Getty Images

Cities tackle a vast array of responsibilities – from building transit networks to running schools – and sometimes they can use a little help. That’s why local governments have long teamed up with businesses in so-called public-private partnerships. Historically, these arrangements have helped cities fund big infrastructure projects such as bridges and hospitals.

However, our analysis and research show an emerging trend with local governments engaged in private-sector collaborations – what we have come to describe as “community-centered, public-private partnerships,” or CP3s. Unlike traditional public-private partnerships, CP3s aren’t just about financial investments; they leverage relationships and trust. And they’re about more than just building infrastructure; they’re about building resilient and inclusive communities.

As the founding executive director of the Partnership for Inclusive Innovation, based out of the Georgia Institute of Technology, I’m fascinated with CP3s. And while not all CP3s are successful, when done right they offer local governments a powerful tool to navigate the complexities of modern urban life.

Together with international climate finance expert Andrea Fernández of the urban climate leadership group C40, we analyzed community-centered, public-private partnerships across the world and put together eight case studies. Together, they offer valuable insights into how cities can harness the power of CP3s.

4 Keys to Success

Although we looked at partnerships forged in different countries and contexts, we saw several elements emerge as critical to success over and over again.

1. Clear mission and vision: It’s essential to have a mission that resonates with everyone involved. Ruta N in Medellín, Colombia, for example, transformed the city into a hub of innovation, attracting 471 technology companies and creating 22,500 jobs.

This vision wasn’t static. It evolved in response to changing local dynamics, including leadership priorities and broader global trends. However, the core mission of entrepreneurship, investment and innovation remained clear and was embraced by all key stakeholders, driving the partnership forward.

2. Diverse and engaged partners: Successful CP3s rely on the active involvement of a wide range of partners, each bringing their unique expertise and resources to the table. In the U.K., for example, the Hull net-zero climate initiative featured a partnership that included more than 150 companies, many small and medium-size. This diversity of partners was crucial to the initiative’s success because they could leverage resources and share risks, enabling it to address complex challenges from multiple angles.

Similarly, Malaysia’s Think City engaged community-based organizations and vulnerable populations in its Penang climate adaptation program. This ensured that the partnership was inclusive and responsive to the needs of all citizens.

3. Robust governance structure: Effective governance is key to ensuring that CP3s operate smoothly and achieve their objectives. For example, in Melbourne, Australia, the City Professorial Chair in Urban Resilience and Innovation includes representatives from the city and a university. It has a formal communication structure where research informs policy and vice versa. It aims to harness the research to better inform and guide policymaking and in turn advance research by putting it into city practice.

In South Africa, the Gauteng City-Region Observatory bridges academia and government to drive urban development. Its governance structure, which includes a diverse board appointed by the province’s premier, ensures that the partnership remains focused and effective. It means that it goes beyond any one organization’s evolving agendas and leadership for longer-term community gains.

4. Commitment to innovation and growth: While we found that securing funding and in-kind support is important, demonstrating economic impact is crucial for the sustainability of CP3s.

Dublin’s Smart Docklands initiative is a prime example of this. By leveraging technology to address community needs, the partnership attracted over 3 million euros (US$3.2 billion) in investments and quadrupled the project’s funding.

The initiative not only boosted Dublin’s connectivity and tech infrastructure but also addressed public safety through solutions such as smart ring buoys. The buoys are life preservers with sensors to alert the city when its buoys are tampered with or stolen.

The case studies show that CP3s can be a globally applicable model for urban development, not merely a passing trend. By fostering collective action, sharing risks and leveraging multiple sources of funding, CP3s can be a powerful tool for cities navigating the challenges and opportunities of the 21st century.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Author:

Debra Lam, Founding Director of the Partnership for Inclusive Innovation, Enterprise Innovation Institute, Georgia Institute of Technology

 
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Shelley Wunder-Smith
shelley.wunder-smith@research.gatech.edu

Dec. 13, 2024
Ulrika Egertsdotter, a principal research scientist in the Renewable Bioproducts Institute, studies plant growth and development in vitro, with forestry, agricultural, and horticultural applications.

The National Science Foundation has released the results of its annual Higher Education Research and Development Survey (HERD), and Georgia Tech has once again moved up again in the rankings.  

The survey of U.S. university research and development expenditures places Georgia Tech as No. 16, up from No. 17 last year, and No. 1 among universities without a medical school. The Institute ranks No. 3 for federally funded research, up from No. 5, and is No. 7 for all externally funded research, up from No. 9. 

“Georgia Tech's continued ascension in research rankings is a testament to the exceptional dedication and collaboration of our faculty, staff, and research sponsors,” said Tim Lieuwen, interim executive vice president for Research. “This trajectory, particularly our rise in federally and externally funded research, amplifies the confidence our partners have in Georgia Tech tackle society’s biggest challenges.”  

The annual survey compiles R&D expenditure data from U.S. colleges and universities with more than $150,000 in research expenditures during a fiscal year. For fiscal year 2023 (July 1, 2022 – June 30, 2023), that included 914 institutions.  Overall, U.S. higher-education R&D spending rose by 11.2%, exceeding $108 billion in fiscal year 2023. This is the largest increase since 2003. 

Georgia Tech’s R&D spending of $1.45 billion in fiscal year 2023 reflects an impressive 17.9% increase — $219 million more — from the previous year for the entire research enterprise, which includes the Georgia Tech Research Institute (GTRI). GTRI remains the largest contributor to Georgia Tech’s growth and continues to play a major role in the Institute’s research enterprise and in national defense research. 

Additionally, Georgia Tech’s R&D expenditures contributed a monumental $1.45 billion to the state of Georgia’s economy, along with continued growth in commercialization efforts that bring technologies out of the lab and into to the world. 

Lieuwen said, “I am proud of these standings and even more excited about the possibilities ahead as we continue to drive innovation that benefits our state, the nation, and the world.” 

About Georgia Tech’s Office of the Executive Vice President for Research 

The Office of the Executive Vice President for Research (EVPR) directs Georgia Tech’s $1.37 billion (FY 2024) portfolio of research, development, and sponsored activities. This includes leadership of the Georgia Tech Research Institute (GTRI), the Enterprise Innovation Institute, nine interdisciplinary research institutes (IRIs) plus research centers, and related research administrative support units: commercialization, corporate engagement, research development and operations, and research administration. Georgia Tech routinely ranks among the top U.S. universities in volume of research conducted.  

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Director of Research Communications

Dec. 13, 2024
Two Cuban brown anoles, Anolis sagrei (Credit: Day's Edge Productions)

Two Cuban brown anoles, Anolis sagrei (Credit: Day's Edge Productions)

A Cuban brown anole (Anolis sagrei) in Miami (Credit: Day's Edge Productions)

A Cuban brown anole (Anolis sagrei) in Miami (Credit: Day's Edge Productions)

A Puerto Rican crested anole, Anolis cristatellus (Credit: Days Edge Productions)

A Puerto Rican crested anole, Anolis cristatellus (Credit: Day's Edge Productions)

In South Florida, two Caribbean lizard species met for the first time. What followed provided some of the clearest evidence to date of evolution in action. 

Lead author James Stroud, an assistant professor in the School of Biological Sciences, was studying Cuban brown anoles (Anolis sagrei) in South Florida when the Puerto Rican crested anole (Anolis cristatellus), suddenly appeared in the region.

Published in Nature Communications, the study documents what happens as the two Anolis lizards adapted in response to the new competitor, while helping to resolve a longstanding challenge in evolutionary biology — directly observing the role of natural selection in character displacement: how similar animals adapt in response to competition.

"Most of what we know about how animals change in response to this process comes from studying patterns that evolved long ago,” Stroud says. “This was a rare opportunity where we could watch evolution as it happened."

Competition from coexistence 

While these two small, brown lizards diverged evolutionarily between 40-60 million years ago and evolved on completely separate Caribbean islands, the two species are nearly identical, and fill similar ecological niches.

So, when the Puerto Rican crested anole suddenly appeared in Cuban brown anole habitat at Fairchild Tropical Botanic Garden in 2018, the two were competing for similar habitats and food sources.

“When two similar species compete for the same resources, like food and territory, they often evolve differences that allow them to coexist,” Stroud says. But, while scientists have found many examples of similar species developing different traits to ease this overlap, “scientists have rarely been able to observe this process as it unfolds in nature.”

Stroud’s team had already been studying Cuban brown anoles at the Fairchild Tropical Botanic Gardens in Miami, Florida, two years prior to when the crested anoles invaded. The team was able to quickly pivot to observe how the invasion changed both species, analyzing the lizards’ changing diets, measuring if the lizards were moving through foliage or on the forest floor, and recording the different species’ locations relative to each other. For over a thousand lizards, they also measured perch height — the distance from the ground that the lizard is perching — a primary marker of how Anolis lizards divvy up habitat.

“We not only observed how these lizards changed their habitat use and behavior when they encountered each other,” says Stroud, “but we also documented the natural selection pressures driving their physical evolution in real-time."

Human-made habitats and natural experiments

The research team found that when these lizard species occur together, they divide up their habitat in predictable ways — the Cuban brown anole shifted to spend more time on the ground, and evolved longer legs to run faster in this habitat, while the slightly larger Cuban crested anole lived in vegetation above the ground. 

"We found that brown anoles with longer legs had higher survival after crested anoles showed up," says Stroud. "This matches perfectly with the physical differences we see in populations where these species have been living together for many generations."

Stroud adds that while the research provides some of the strongest observations of evolution in action to date, it also demonstrates how human activities can create natural experiments that help us understand fundamental evolutionary processes — both species of Anolis lizard in the study were originally non-native to South Florida.

“As species increasingly come into contact due to human-mediated introductions and climate change, these studies may be important for predicting how communities will respond,” he says. "By studying these non-native lizards who are meeting each other for the first time in their existence, we had a unique opportunity to see the actual process unfold and connect it to the patterns we observe in nature."

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Contact: Jess Hunt-Ralston

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