Ph.D. student Ziqi Zhang has built a career blending machine learning with single-cell biology. His work helps scientists study cellular mechanisms that advance disease research and drug development.

Though decorated with awards and appearances in leading journals, Zhang will achieve his greatest accomplishment tonight at McCamish Pavilion. He will join the Class of 2025 in walking across the stage, receiving diplomas, and graduating from Georgia Tech.

Before he “gets out” of Georgia Tech, we interviewed Zhang to learn more about his Ph.D. journey and where his degree will take him next. 

Graduate: Ziqi Zhang

Research Interests: Machine learning, foundational models, cellular mechanisms, single-cell gene sequencing, gene regulatory networks

Education: Ph.D. in Computational Science and Engineering

Faculty Advisor: School of CSE J.Z. Liang Early-Career Associate Professor Xiuwei Zhang

What persuaded you to study at Georgia Tech? 

I chose Georgia Tech because it is one of the top engineering institutions in the United States, known for its strength in machine learning and data science. The university offers exceptional research resources and the opportunity to work with leading scholars in my field. Georgia Tech also has very good research infrastructure. The Coda Building is one of the most well-designed and productive research environments I have experienced. Having access to such a space has been a genuine privilege.

How has working on your CSE degree helped you so far in your career?

Working toward my CSE degree has been instrumental in my career development. As an interdisciplinary program, CSE has equipped me with strong computational skills while also deepening my understanding of key application domains. This breadth of training has opened more opportunities during my job and internship searches. In addition, CSE community events, such as HotCSE, the weekly coffee hour, and faculty recruiting activities, have helped me strengthen my scientific communication skills, which are essential for my long-term career growth.

What research project from Georgia Tech are you most proud of?

My favorite research project was scMoMaT, a matrix tri-factorization algorithm for single-cell data integration. I invested a significant amount of time and effort into this work, iterating on the model many times. I’m very proud that it ultimately evolved into a clean, robust, and elegant algorithm.

What advice would you give someone interested in graduate school?

It is important to find an advisor who is supportive and genuinely invested in your career development. A Ph.D. is not an easy journey, and you will inevitably encounter challenges along the way. Having an advisor who can provide thoughtful guidance and dedicated mentorship is one of the most crucial factors in helping you navigate those difficulties.

What is your most favorite memory from Georgia Tech?

CSE’s new student campus visit day every year was one of my favorite times of the year. It was always fun to meet new people, have good food, and enjoy the beautiful view from the Coda rooftop.

What are your plans after graduation?

I plan to keep working in academia after graduation. I’m on the job hunt, currently applying for positions and preparing for interviews.

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Proteins, including antibodies, hemoglobin, and insulin, power nearly every vital aspect of life. Breakthroughs in protein research are producing vaccines, resilient crops, bioenergy sources, and other innovative technologies.

Despite their importance, most of what scientists know about proteins only comes from a small sample size. This stands in the way of fully understanding how most proteins work and unlocking their full potential.

Georgia Tech’s Yunan Luo believes artificial intelligence (AI) could fill this knowledge gap. The National Science Foundation agrees. Luo is the recipient of an NSF Faculty Early Career Development (CAREER) award. 

“So much of biology depends on knowing what proteins do, but decades of research have concentrated on a relatively small set of well-studied proteins. This imbalance in scientific attention leads to a distorted view of the biological landscape that quietly shapes our data and our algorithms,” Luo said.

“My group’s goal is to build machine learning (ML) models that actively close this gap by generating trustworthy function predictions for the many proteins that remain understudied.”

[Related: Yunan Luo to use AI for Protein Design and Discovery with Support of $1.8 Million NIH Grant]

In his proposal to NSF, Luo coined this rich-get-richer effect “annotation inequality.” 

One problem of annotation inequality is that it slows progress in disease prognosis, drug discovery, and other critical biomedical areas. It is challenging to innovate the few proteins that scientists already know so much about. 

A cascading effect of annotation inequality is that it diminishes the effectiveness of studying proteins with AI.  

AI methods learn from existing experimental data. Datasets skewed toward well-known proteins propagate and become entrenched in models. Over time, this makes it harder for computers to research understudied proteins. 

“Protein annotation inequality creates an effect analogous to a vast library where 95% of patrons only read the top 5% popular books, leaving the rest of the collection to gather dust,” Luo said.

“This has resulted in knowledge disparities across proteins in current literature and databases, biasing our understanding of protein functions.”

The NSF CAREER award will fund Luo with over $770,000 for the next five years to tackle head-on the problem of protein annotation inequality.

Luo will use the grant to build an accurate, unbiased protein function prediction framework at scale. His project aims to:

• Reveal how annotation inequality affects protein function prediction systems
• Create ML techniques suited for biological data, which is often noisy, incomplete, and imbalanced  
• Integrate data and ML models into a scalable framework to accelerate discoveries involving understudied proteins

More enduring than the ML framework, Luo will leverage the NSF award to support educational and outreach programs. His goal is to groom the next generation of researchers to study other challenges in computational biology, not just the annotation inequality problem.

Luo teaches graduate and undergraduate courses focused on computational biology and ML. Problems and methods developed through the CAREER project can be used as course material in his classes.

Luo also championed collaboration with Georgia Tech’s Center for Education Integrating Science, Mathematics, and Computing (CEISMC) in his proposal. 

Through this partnership, local high school teachers and students would gain access to his data and models. This promotes deeper learning of biology and data science through hands-on experience with real-world tools.  

Luo sees reaching students and the community as a way of paying forward the support he received from Georgia Tech colleagues. 

“I am incredibly grateful for this recognition from the NSF,” said Luo, an assistant professor in the School of Computational Science and Engineering (CSE). 

“This would not have been possible without my students and collaborators, whose hard work laid the groundwork for this proposal.”

Luo praised CSE faculty members B. Aditya Prakash, Xiuwei Zhang, and Chao Zhang for their guidance. All three study machine learning and computational bioscience, two of CSE’s five core research areas. 

Luo also thanked Haesun Park for her support and recommendation for the CAREER award. Park is a Regents’ Professor and the chair of the School of CSE.

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The Institute for Matter and Systems (IMS) hosted the inaugural Boundaries and Breakthroughs panel on Nov. 11, setting the stage for a new era of interdisciplinary dialogue at Georgia Tech. The event, held in the Marcus Nanotechnology building, brought together experts in electrical engineering, computer architecture, and computer systems design to tackle one of today’s pressing challenges: artificial intelligence (AI) scalability and sustainable high-performance computing.

As one of Georgia Tech’s 11 interdisciplinary research institutes, IMS is designed to break down silos between traditional academic units. By operating core user facilities and fostering collaborative research, IMS creates a unique ecosystem where device-level innovation meets systems-level design. This event personified that mission by connecting researchers who typically work on different ends of the stack.

“We’re looking for opportunities to bring people together to have discussions that are both informative and potentially create a little bit of friction in the best possible way around trending topics in science and engineering,” said Mike Filler, IMS deputy director, during opening remarks.

The panel was moderated by Divya Mahajan, assistant professor in the School of Electrical and Computer Engineering, and featured Moinuddin Qureshi, professor of computer science; Anand Iyer, assistant professor of computer science; and Asif Khan, associate professor in electrical and computer engineering. 

The discussion explored the dynamics between compute abundance and energy constraints. As AI models scale up, power consumption has become a societal issue, driving up energy demands and even influencing political conversations. The panelists agreed that the bottleneck isn’t compute — a computer’s ability to process and execute tasks — but data movement. Moving data uses 100 to 1,000 times more energy than computation, making memory systems the critical frontier.

The conversation highlighted how breakthroughs in compute must occur at every layer — from individual devices to full computer systems. At the device level, Khan mentioned emerging memory technologies and “beyond CMOS” approaches such as embedding compute within memory and exploring bio-inspired architectures.

From a computer architecture level, Qureshi advocated rethinking interfaces and creating designs optimized for the future of computing. AI needs regular patterns to work optimally, and current patterns are not set up for that.

“If you want efficiency, design systems that make sense for AI,” Qureshi said. “Develop new interfaces, develop new modules, architectures, and organization that make for a specific pattern.”

At the systems level, Iyer stressed practical strategies like near-memory compute and energy-aware scheduling while acknowledging the need for co-design between hardware and software.

“Now in terms of brains or bio-inspired computing, my conjecture is that there is currently no hardware that is capable of doing it,” Khan said. He also noted that right now, there is no computer or algorithm that has the scale of computing comparable to human brain power.

The panelists didn’t shy away from provocative ideas — such as whether graphic processing units are the final solution for AI and whether matrix multiplication alone can lead to artificial general intelligence. While opinions varied, all agreed that organizations like IMS are key to bringing together diverse expertise to tackle these questions collaboratively.

The Boundaries and Breakthroughs series continues in January with a panel on bioelectronics and medical technologies, reinforcing IMS’s commitment to fostering dialogue that spans the full spectrum of innovation.

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Viral videos abound with humanoid robots performing amazing feats of acrobatics and dance but finding videos of a humanoid robot performing a common household task or traversing a new multi-terrain environment easily, and without human control, are much rarer. This is because training humanoid robots to perform these seemingly simple functions involves the need for simulation training data that lack the complex dynamics and degrees of freedom of motion that are inherent in humanoid robots. 

To achieve better training outcomes with faster deployment results, Fukang Liu and Feiyang Wu, graduate students under Professor Ye Zhao from the Woodruff School of Mechanical Engineering and faculty member of the Institute for Robotics and Intelligent Machines, have published a duo of papers in IEEE Robotics and Automation Letters. This is a collaborative work with three other IRIM affiliated faculties, Profs. Danfei Xu, Yue Chen, and Sehoon Ha, as well as Prof. Anqi Wu from School of Computational Science and Engineering.

To develop more reliable motion learning for humanoid robots and enable humanoid robots to perform complex whole-body movements in the real world, Fukang led a team and developed Opt2Skill, a hybrid robot learning framework that combines model-based trajectory optimization with reinforcement learning.  Their framework integrates dynamics and contacts into the trajectory planning process and generates high-quality, dynamically feasible datasets, which result in more reliable motion learning for humanoid robots and improved position tracking and task success rates. This approach shows a promising way to augment the performance and generalization of humanoid RL policies using dynamically feasible motion datasets. Incorporating torque data also improved motion stability and force tracking in contact-rich scenarios, demonstrating that torque information plays a key role in learning physically consistent and contact-rich humanoid behaviors.

While other datasets, such as inverse kinematics or human demonstrations, are valuable, they don’t always capture the dynamics needed for reliable whole-body humanoid control.” said by Fukang Liu. “With our Opt2Skill framework, we combine trajectory optimization with reinforcement learning to generate and leverage high-quality, dynamically feasible motion data. This integrated approach gives robots a richer and more physically grounded training process, enabling them to learn these complex tasks more reliably and safely for real-world deployment. - Fukang Liu

In another line of humanoid research, Feiyang established a one-stage training framework that allows humanoid robots to learn locomotion more efficiently and with greater environmental adaptability. Their framework, Learn-to-Teach (L2T), unlike traditional two-stage “teacher-student” approaches, which first train an expert in simulation and then retrain a limited-perception student, teaches both simultaneously, sharing knowledge and experiences in real time. The result of this two-way training is a 50% reduction in training data and time, while maintaining or surpassing state-of-the-art performance in humanoid locomotion. The lightweight policy learned through this process enables the lab’s humanoid robot to traverse more than a dozen real-world terrains—grass, gravel, sand, stairs, and slopes—without retraining or depth sensors.

By training an expert and a deployable controller together, we can turn rich simulation feedback into a lightweight policy that runs on real hardware, letting our humanoid adapt to uneven, unstructured terrain with far less data and hand-tuning than traditional methods. - Feiyang Wu

By the application of these training processes, the team hopes to speed the development of deployable humanoid robots for home use, manufacturing, defense, and search and rescue assistance in dangerous environments. These methods also support advances in embodied intelligence, enabling robots to learn richer, more context-aware behaviors.Additionally, the training data process can be applied to research to improve the functionality and adaptability of human assistive devices for medical and therapeutic uses.

As humanoid robots move from controlled labs into messy, unpredictable real-world environments, the key is developing embodied intelligence—the ability for robots to sense, adapt, and act through their physical bodies,” said Professor Ye Zhao. “The innovations from our students push us closer to robots that can learn robust skills, navigate diverse terrains, and ultimately operate safely and reliably alongside people. - Prof. Ye Zhao

Author - Christa M. Ernst

Citations

Liu F, Gu Z, Cai Y, Zhou Z, Jung H, Jang J, Zhao S, Ha S, Chen Y, Xu D, Zhao Y. Opt2skill: Imitating dynamically-feasible whole-body trajectories for versatile humanoid loco-manipulation. IEEE Robotics and Automation Letters. 2025 Oct 13.

Wu F, Nal X, Jang J, Zhu W, Gu Z, Wu A, Zhao Y. Learn to teach: Sample-efficient privileged learning for humanoid locomotion over real-world uneven terrain. IEEE Robotics and Automation Letters. 2025 Jul 23.
 

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The Georgia Tech Library is proud to show a new piece from Hyojin Kwon and Nix Liu Xin on the Media Bridge, Synthetic Ecologies: AI-Translated Matter in Architectural Media.

The four-minute piece, which went live in November, is playing every hour at the ten-minute mark on Media Bridge, located between Price Gilbert and Crosland Tower.

About Synthetic Ecologies: AI-Translated Matter in Architectural Media

Rather than accelerating images, Synthetic Ecologies asks “how matter thinks.” New Materialism treats matter as an active partner; design emerges where human intention intra-acts with things, datasets, models, and light. Authorship becomes orchestration, and every dataset a canon—a politics of selection. Method, therefore, is ethics.

The project authors a white model first, fixing space, camera, light, and motion as temporal logic. AI then enters as a translator, moving on rails of depth/normal/segmentation with flow consistency. The surface reveals signs of behavior—gloss, scattering, porosity, accretion—rather than mere style. We publish provenance—sources and biases, node graphs and parameters, timelines and versions—so choices are traceable and contestable, transferable to learning, practice, and public decision.

From plastic toward a synthetic ecology, the work declares architecture thinking with media. AI is not authority but a transparent amplifier; authorship is not surrendered.

Spanning the Library, the Media Bridge is a civic threshold of study and routine, a common ceiling shared day and night. Installed overhead, the flow of plastics becomes a sky that prompts daily audiences to reflect on circulation, responsibility, and bias. Open provenance turns the piece into a public manifesto, linking campus AI literacy and circularity agendas to civic practice. The work does more than show images; it proposes a public curriculum where data and decisions, materials and culture, negotiate in view of the community.

Artist Bios

Hyojin Kwon is an Assistant Professor in the School of Architecture at the Georgia Institute of Technology and cofounder of Pre- and Post-, a research-driven design practice based in Atlanta and Boston. Her work explores how digital media — including animation, simulation, and AI-assisted image workflows — can function as both generative and critical tools within architectural design. Situated within a post digital framework, her recent projects investigate material agency and synthetic ecologies, often translating computational processes into civic installations and experimental representations. Her work has been exhibited internationally, including at the Museum of Brisbane, Tokyo Designers Week, Seoul Foundation for Arts and Culture, and Atlanta Contemporary, and supported by institutions such as MacDowell, Art Omi, and Autodesk.

Nix Liu Xin is a spatial computing artist and director, Harvard graduate, and the founder & CEO of OI (Onceness Intelligence), an experiential-AI startup. He envisions a future where 4D–AI interfaces enable everyone to record life moments, relive memories, and design immersive spatial experiences through intelligent 4D media.

He was named to the AACYF 30 Under 30 and has received accolades such as the Harvard Design Studies Domain Award, the CGarchitect 3D Awards, and the MIT AI Film Hack Award for Best Picture. 

Additionally, Nix was featured as an artist at the Lianzhou Photography Biennale. He also co-founded the HarvardXR Conference and the Creative.Tech Community.

One of the top conferences for AI and computer games is recognizing a School of Interactive Computing professor with its first-ever test-of-time award.

At its event this week in Alberta, Canada, the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment (AIIDE) is honoring Professor Mark Riedl. The award also honors University of Utah Professor and Division of Games Chair Michael Young, Riedl’s Ph.D. advisor.

Riedl studied under Young at North Carolina State University.

Their 2005 paper, From Linear Story Generation to Branching Story Graphs, highlighted the challenges of using AI to create interactive gaming narratives in which user actions influence the story’s progression. 

In 2005, computer game systems that supported linear, non-branching games were widely used. Riedl introduced an innovative mathematical formula for interactive stories ranging from choose-your-own-adventure novels to modern computer games.

“We didn’t use the term ‘generative AI’ back then, but I was working on AI for the generation of creative artifacts,” Riedl said. “This was before we had practical deep learning or large language models.

“One of the reasons this paper is still relevant 20 years later is that it didn’t just present a technology, it attempted to provide a framework for solving a grand challenge in AI.”

That challenge is still ongoing, Riedl said. Game designers continue to struggle with balancing story coherence against the amount of narrative control afforded to users.

“When users exercise a high degree of control within the environment, it is likely that their actions will change the state of the world in ways that may interfere with the causal dependencies between actions as intended within a storyline,” Riedl and Young wrote in the paper.

“Narrative mediation makes linear narratives interactive. The question is: Is the expressive power of narrative mediation at least as powerful as the story graph representation?”

AIIDE is being held this week at the University of Alberta in Edmonton, Alberta. Riedl will receive the award on Wednesday.

School of Mathematics Professor Anton Leykin is part of a research team selected to receive support through the AI for Math Fund, a new grant program created to accelerate the development of artificial intelligence (AI) and machine learning tools for mathematics.

“This grant gives me a foothold in a new world where AI can be used in a very concrete way,” says Leykin. “It’s an opportunity to move beyond the hype and develop tools that truly benefit mathematical research.”

With a total of $18 million in inaugural grants to 29 project teams, the AI for Math Fund backs initiatives that create open-source tools, expand high-quality datasets for AI training, and make advanced systems more accessible to mathematicians. The fund received 280 grant applications from researchers and mathematicians worldwide. 

Building bridges

Leykin’s global team includes researchers from the University of South Carolina, University of Warwick, and Cornell University. Their project, “Bridging Proof and Computation: For a Verified Lean-Macaulay2 Interface,” aims to connect two powerful systems: Lean, a platform for assisting and formalizing mathematical proofs, and Macaulay2, a computational algebra system widely used in research.

By developing a native interface — a built-in connection that allows the two systems to work together without external tools — and a Lean-based domain-specific language, the project will enable communication between these systems. This will allow Lean users to formulate tactics that involve sophisticated computation done by algorithms implemented in Macaulay2; in return, Macaulay2 users can formalize computer-assisted proofs via Lean with a little help from AI.

“This integration has the potential to transform how mathematicians work,” says Leykin. “It will not only connect Lean and Macaulay2 but also lay the groundwork for a general interface that could benefit other computer algebra systems in the future.”

His goal is to create a robust proof-assistance system where AI can help generate strategies and validate proofs, driving progress in areas that require both computational power and rigorous verification.

About the AI for Math Fund

A joint initiative developed in partnership between Renaissance Philanthropy and founding donor XTX Markets, the AI for Math Fund is one of the largest philanthropic commitments supporting the development of AI and machine learning tools to advance mathematics. Individual grants range up to $1 million for 24 months of work on open-source projects and research.

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Pop culture has often depicted robots as cold, metallic, and menacing, built for domination, not compassion. But at Georgia Tech, the future of robotics is softer, smarter, and designed to help.

“When people think of robots, they usually imagine something like The Terminator or RoboCop: big, rigid, and made of metal,” said Hong Yeo, the G.P. “Bud” Peterson and Valerie H. Peterson Professor in the George W. Woodruff School of Mechanical Engineering. “But what we’re developing is the opposite. These artificial muscles are soft, flexible, and responsive — more like human tissue than machine.”

Yeo’s latest study, published in Materials Horizons, explores AI-powered muscles made from lifelike materials paired with intelligent control systems. The technology learns from the body and adapts in real time, creating motion that feels natural, responsive, and safe enough to support recovery.
 

Muscles That Think, Materials That Feel

Traditional robotics relies on steel, wires, and motors, but rarely captures the nuances of human motion. Yeo’s research takes a different approach. He uses hierarchically structured fibers, which are flexible materials built in layers, much like muscle and tendon. They can sense, adapt, and even “remember” how they’ve moved before.

Yeo trains machine learning algorithms to adjust those pliable materials in real time with the right amount of force or flexibility for each task.

“These muscles don’t only respond to commands,” Yeo said. “They learn from experience. They can adapt and self-correct, which makes motion smoother and more natural.”

The result of that research is deeply human. For someone recovering from a stroke or limb loss, each deliberate movement rebuilds not just strength — it rebuilds confidence, independence, and a sense of self.

 

A Glove That Gives Freedom Back

One of the first real-world applications is a prosthetic glove powered by artificial muscles (published in ACS Nano, 2025), a device that behaves more like a helping hand than a mechanical tool. Traditional prosthetics rely on rigid motors and preset motions, but Yeo’s design mirrors the natural give-and-take of real muscle.

Inside the glove, thin layers of stretchable fibers and sensors contract, twist, and flex in sync with the wearer’s intent. The glove can fine-tune grip strength, reduce tremors, and respond instantly to the user’s movements, bringing dexterity back to everyday life.

That kind of precision matters most in the smallest tasks: fastening a button, lifting a glass, holding a child’s hand.

“These aren’t just movements,” Yeo said. “They’re freedoms.”

For Yeo, the idea of restoring freedom through movement has driven his research from the very beginning.
 

A Mission Rooted in Loss

Yeo's work is deeply personal. His path to biomedical engineering began with loss — the sudden death of his father while Yeo was still in college. That moment reshaped his sense of purpose, redirecting his focus from machines that move to technologies that heal.

“Initially, I was thinking about designing cars,” he said. “But after my father’s death, I kind of woke up. Maybe I could do something that helps save someone’s life.”

That purpose continues to guide his lab’s work today, building technologies that help people recover what they’ve lost.

Achieving that vision, however, means tackling some of engineering’s toughest challenges.
 

Soft Machines, Hard Problems

Creating lifelike muscles isn’t easy. They need to be soft but strong, responsive but safe. And they must avoid triggering the body’s immune system. That means building materials that can survive inside the body — and learn to belong there.

“We always think about not only function, but adaptability,” Yeo said. “If it’s going to be part of someone’s body, it has to work with them, not against them.”

His team calibrates these synthetic fibers like precision instruments — tested, adjusted, and re-tuned until they operate in sync with the body’s natural movements. Over time, they develop a kind of “muscle memory,” adapting fluidly to changing conditions. That dynamic adaptability, Yeo explained, is what separates a machine from a prosthetic that truly feels alive.
 

From Collaboration to Innovation

Solving problems this complex requires more than one discipline. It takes an entire ecosystem of collaboration. Yeo’s lab brings together experts in mechanical engineering, materials science, medicine, and computer science to design smarter, safer devices.

“You can’t solve this kind of problem in isolation,” he said. “We need all of it — polymers, artificial intelligence, biomechanics — working together.”

That collaborative model is supported by the National Science Foundation (NSF), the National Institutes of Health, and Georgia Tech’s Institute for Matter and Systems. In 2023, Yeo received a $3 million NSF grant to train the next generation of engineers building smart medical technology.

His team now works closely with healthcare providers and industry partners to bring these devices out of the lab and into patients’ lives.


The Future You Can Feel

The future of robotics, according to Yeo, won’t be defined by power or complexity but by feel.

“If it feels foreign, people won’t use it,” he said. “But if it feels like part of you, that’s when it can truly change lives.”

It’s the opposite of The Terminator, where machines replace us. Yeo is designing these machines to help us reclaim ourselves.

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