In 2017, a long, oddly shaped asteroid passed by Earth. Called ‘Oumuamua, it was the first known interstellar object to visit our solar system, but it wasn’t an isolated incident — less than two years later, in 2019, a second interstellar object (ISO) was discovered. 

“‘Oumuamua was found passing just 15 million miles from Earth — that’s much closer than Mars or Venus,” says James Wray. “But it was formed in an entirely different solar system. Studying these objects could give us incredible insight into extrasolar planets, and how our planet fits into the universe.”

Wray, a professor in the School of Earth and Atmospheric Sciences at Georgia Tech, has just been awarded a Simons Foundation Pivot Fellowship to do just that. Pivot Fellowships are among the most prestigious sources of funding for cutting-edge research, and support leading researchers who have the deep interest, curiosity and drive to make contributions to a new discipline.

Wray has primarily studied the geoscience of Mars. He will leverage knowledge of nearby planets to understand ISOs and planets much farther away. “I want to understand how planets got to be the way they are, and if they could have ever hosted life,” he explains. “Extrasolar planets give us many more places to ask those questions than our solar system does, but they're too distant to visit with spacecraft. ISOs provide a unique opportunity to explore other solar systems without leaving our own.”

The Fellowship will provide salary support as well as funding for research, travel, and professional development. “Seed funds like this are so valuable,” says Wray. “I’m incredibly grateful to the Simons Foundation. I’d also like to thank Georgia Tech for its support,” he adds, sharing that the Center for Space Technology and Research supported a related research effort at the University of Hawaii earlier this year. “My mentor and I were able to spend some of that time improving our Pivot Fellowship proposal, which played a critical role in securing this Fellowship.”

In search of ISOs

Wray will study small solar system bodies like asteroids and comets to decode the processes of planet formation and space weathering, and will analyze data from the 2017 and 2019 ISOs.

He will also work alongside collaborators including Karen Meech of the University of Hawaii, who led the paper characterizing ‘Oumuamua, to conceptualize what an intercept mission might look like. 

“We still have a lot of questions regarding ISOs,” he says. “Hundreds of papers have already been written about them, but we still don't know the answers.” One key mystery is the composition of the bodies: both the 2017 and 2019 objects were compositionally different from those in our solar system.

“Are they inherently different from the bodies in our solar system, or did the long journey to our solar system make them that way? Is our solar system different from others?” Wray asks. “We could answer so many questions with even a simple picture of the next ISO that comes close enough for us to intercept with spacecraft.”

A cosmic timeline

While there is no guarantee that another ISO might be spotted in our solar system, the timing is opportune — upcoming telescope surveys are poised to detect such interstellar objects. “In mid-2025, when I will start this Fellowship, the new Rubin Observatory will begin scanning the entire sky,” Wray says. “It has the potential to discover up to several new ISOs per year.”

“ISO visits are always brief,” he adds, “so the research needs to be in place for when one is spotted.” If an interstellar object is detected, Wray and Meech will be poised to leverage specialized telescopes in Hawaii, along with others worldwide, to better understand it, studying its size, shape, and composition — and potentially sending spacecraft to image it.

“We might never find another ISO — or they might be the key to imminent breakthroughs in understanding our place in the galaxy,” Wray adds. “I'm extremely grateful to the Simons Foundation for the flexibility to pursue this research at whatever pace the cosmos allows.”

The Institute for Matter and Systems (IMS) at Georgia Tech has announced the fall 2024 core facility seed grant recipients. The primary purpose of this program is to give graduate students in diverse disciplines working on original and unfunded research in micro- and nanoscale projects the opportunity to access the most advanced academic cleanroom space in the Southeast. In addition to accessing the labs' high-level fabrication, lithography, and characterization tools, the awardees will have the opportunity to gain proficiency in cleanroom and tool methodology and access the consultation services provided by research staff members in IMS. Seed Grant awardees are also provided travel support to present their research at a scientific conference.

In addition to student research skill development, this biannual grant program gives faculty with novel research topics the ability to develop preliminary data to pursue follow-up funding sources. The Core Facility Seed Grant program is supported in part by the Southeastern Nanotechnology Infrastructure Corridor (SENIC), a member of the National Science Foundation’s National Nanotechnology Coordinated Infrastructure (NNCI).

The five winning projects in this round were awarded IMS cleanroom and lab access time to be used over the next year. 

The Fall 2024 IMS Core Facility Seed Grant recipients are:

Manufacturing of a Diamagnetically Enhanced PEM Electrolysis Cell
PI: Alvaro Romero-Calvo
Student: Shay Vitale
Daniel Guggenheim School of Aerospace Engineering

Biomimicking Organ-On-a-Chip Models
PI: Nick Housley
Student: Aref Valipour
School of Biological Sciences                                                            

Single-shot LWIR Hyperspectral Imaging Using Meta-optics
PI: Shu Jia
Student: Jooyeong Yun (School of Electrical and Computer Engineering)
The Wallace H. Coulter Department of Biomedical Engineering

Large-area Three-dimensional Nanolithography Using Two-photon Polymerization
PI: Sourabh Saha
Student: Golnaz Aminaltojjari
George W. Woodruff School of Mechanical Engineering

Effects of Geochemical Constraints on the Redistribution of Rare Earth Elements (REE) during Chemical Weathering
PI: Yuanzhi Tang
Student: Hang Xu
School of Earth and Atmospheric Sciences

Amino acids are essential for nearly every process in the human body. Often referred to as ‘the building blocks of life,’ they are also critical for commercial use in products ranging from pharmaceuticals and dietary supplements, to cosmetics, animal feed, and industrial chemicals. 

And while our bodies naturally make amino acids, manufacturing them for commercial use can be costly — and that process often emits greenhouse gasses like carbon dioxide (CO2).

In a landmark study, a team of researchers has created a first-of-its kind methodology for synthesizing amino acids that uses more carbon than it emits. The research also makes strides toward making the system cost-effective and scalable for commercial use. 

“To our knowledge, it’s the first time anyone has synthesized amino acids in a carbon-negative way using this type of biocatalyst,” says lead corresponding author Pamela Peralta-Yahya, who emphasizes that the system provides a win-win for industry and environment. “Carbon dioxide is readily available, so it is a low-cost feedstock — and the system has the added bonus of removing a powerful greenhouse gas from the atmosphere, making the synthesis of amino acids environmentally friendly, too.”

The study, “Carbon Negative Synthesis of Amino Acids Using a Cell-Free-Based Biocatalyst,” published today in ACS Synthetic Biology, is publicly available. The research was led by Georgia Tech in collaboration with the University of Washington, Pacific Northwest National Laboratory, and the University of Minnesota.

The Georgia Tech research contingent includes Peralta-Yahya, a professor with joint appointments in the School of Chemistry and Biochemistry and School of Chemical and Biomolecular Engineering (ChBE); first author Shaafique Chowdhury, a Ph.D. student in ChBE; Ray Westenberg, a Ph.D student in Bioengineering; and Georgia Tech alum Kimberly Wennerholm (B.S. ChBE ’23).

Costly chemicals

There are two key challenges to synthesizing amino acids on a large scale: the cost of materials, and the speed at which the system can generate amino acids.

While many living systems like cyanobacteria can synthesize amino acids from CO2, the rate at which they do it is too slow to be harnessed for industrial applications, and these systems can only synthesize a limited number of chemicals.

Currently, most commercial amino acids are made using bioengineered microbes. “These specially designed organisms convert sugar or plant biomass into fuel and chemicals,” explains first author Chowdhury, “but valuable food resources are consumed if sugar is used as the feedstock — and pre-processing plant biomass is costly.” These processes also release CO2 as a byproduct.

Chowdhury says the team was curious “if we could develop a commercially viable system that could use carbon dioxide as a feedstock. We wanted to build a system that could quickly and efficiently convert CO2 into critical amino acids, like glycine and serine.”

The team was particularly interested in what could be accomplished by a ‘cell-free’ system that leveraged some process of a cellular system — but didn’t actually involve living cells, Peralta-Yahya says, adding that systems using living cells need to use part of their CO2 to fuel their own metabolic processes, including cell growth, and have not yet produced sufficient quantities of amino acids.

“Part of what makes a cell-free system so efficient,” Westenberg explains, “is that it can use cellular enzymes without needing the cells themselves. By generating the enzymes and combining them in the lab, the system can directly convert carbon dioxide into the desired chemicals. Because there are no cells involved, it doesn’t need to use the carbon to support cell growth — which vastly increases the amount of amino acids the system can produce.”

A novel solution

While scientists have used cell-free systems before, one of the necessary chemicals, the cell lysate biocatalyst, is extremely costly. For a cell-free system to be economically viable at scale, the team needed to limit the amount of cell lysate the system needed.

After creating the ten enzymes necessary for the reaction, the team attempted to dilute the biocatalyst using a technique called ‘volumetric expansion.’ “We found that the biocatalyst we used was active even after being diluted 200-fold,” Peralta-Yahya explains. “This allows us to use significantly less of this high-cost material — while simultaneously increasing feedstock loading and amino acid output.”

It’s a novel application of a cell-free system, and one with the potential to transform both how amino acids are produced, and the industry’s impact on our changing climate. 

“This research provides a pathway for making this method cost-effective and scalable,” Peralta-Yahya says. “This system might one day be used to make chemicals ranging from aromatics and terpenes, to alcohols and polymers, and all in a way that not only reduces our carbon footprint, but improves it.”

Funding: Advanced Research Project Agency-Energy (ARPA-E), U.S. Department of Energy and the U.S. Department of Energy, Office of Science, Biological and Environmental Research Program.

DOI: 10.1021/acssynbio.4c00359

A first-of-its-kind algorithm developed at Georgia Tech is helping scientists study interactions between electrons. This innovation in modeling technology can lead to discoveries in physics, chemistry, materials science, and other fields.

The new algorithm is faster than existing methods while remaining highly accurate. The solver surpasses the limits of current models by demonstrating scalability across chemical system sizes ranging from large to small. 

Computer scientists and engineers benefit from the algorithm’s ability to balance processor loads. This work allows researchers to tackle larger, more complex problems without the prohibitive costs associated with previous methods.

Its ability to solve block linear systems drives the algorithm’s ingenuity. According to the researchers, their approach is the first known use of a block linear system solver to calculate electronic correlation energy.

The Georgia Tech team won’t need to travel far to share their findings with the broader high-performance computing community. They will present their work in Atlanta at the 2024 International Conference for High Performance Computing, Networking, Storage and Analysis (SC24).

[MICROSITE: Georgia Tech at SC24] 

“The combination of solving large problems with high accuracy can enable density functional theory simulation to tackle new problems in science and engineering,” said Edmond Chow, professor and associate chair of Georgia Tech’s School of Computational Science and Engineering (CSE).

Density functional theory (DFT) is a modeling method for studying electronic structure in many-body systems, such as atoms and molecules. 

An important concept DFT models is electronic correlation, the interaction between electrons in a quantum system. Electron correlation energy is the measure of how much the movement of one electron is influenced by presence of all other electrons.

Random phase approximation (RPA) is used to calculate electron correlation energy. While RPA is very accurate, it becomes computationally more expensive as the size of the system being calculated increases.

Georgia Tech’s algorithm enhances electronic correlation energy computations within the RPA framework. The approach circumvents inefficiencies and achieves faster solution times, even for small-scale chemical systems.

The group integrated the algorithm into existing work on SPARC, a real-space electronic structure software package for accurate, efficient, and scalable solutions of DFT equations. School of Civil and Environmental Engineering Professor Phanish Suryanarayana is SPARC’s lead researcher.

The group tested the algorithm on small chemical systems of silicon crystals numbering as few as eight atoms. The method achieved faster calculation times and scaled to larger system sizes than direct approaches.

“This algorithm will enable SPARC to perform electronic structure calculations for realistic systems with a level of accuracy that is the gold standard in chemical and materials science research,” said Suryanarayana.

RPA is expensive because it relies on quartic scaling. When the size of a chemical system is doubled, the computational cost increases by a factor of 16. 

Instead, Georgia Tech’s algorithm scales cubically by solving block linear systems. This capability makes it feasible to solve larger problems at less expense. 

Solving block linear systems presents a challenging trade-off in solving different block sizes. While larger blocks help reduce the number of steps of the solver, using them demands higher computational cost per step on computer processors. 

Tech’s solution is a dynamic block size selection solver. The solver allows each processor to independently select block sizes to calculate. This solution further assists in scaling, and improves processor load balancing and parallel efficiency.

“The new algorithm has many forms of parallelism, making it suitable for immense numbers of processors,” Chow said. “The algorithm works in a real-space, finite-difference DFT code. Such a code can scale efficiently on the largest supercomputers.”

Georgia Tech alumni Shikhar Shah (Ph.D. CSE 2024), Hua Huang (Ph.D. CSE 2024), and Ph.D. student Boqin Zhang led the algorithm’s development. The project was the culmination of work for Shah and Huang, who completed their degrees this summer. John E. Pask, a physicist at Lawrence Livermore National Laboratory, joined the Tech researchers on the work.

Shah, Huang, Zhang, Suryanarayana, and Chow are among more than 50 students, faculty, research scientists, and alumni affiliated with Georgia Tech who are scheduled to give more than 30 presentations at SC24. The experts will present their research through papers, posters, panels, and workshops. 

SC24 takes place Nov. 17-22 at the Georgia World Congress Center in Atlanta. 

“The project’s success came from combining expertise from people with diverse backgrounds ranging from numerical methods to chemistry and materials science to high-performance computing,” Chow said.

“We could not have achieved this as individual teams working alone.”

The National Science Foundation (NSF) awarded a syndicate of eight Southeast universities — with Georgia Tech as the lead — a $15 million grant to support the development of a regional innovation ecosystem that addresses underrepresentation and increases entrepreneurship and technology-oriented workforce development. 

The NSF Innovation Corps (I-Corps) Southeast Hub is a five-year project based on the I-Corps model, which assists academics in moving their research from the lab to the market. 

Led by Georgia Tech’s Office of Commercialization and Enterprise Innovation Institute, the NSF I-Corps Southeast Hub encompasses four states — Georgia, Florida, South Carolina, and Alabama. 

Its member schools include:

• Clemson University 
• Morehouse College 
• University of Alabama 
• University of Central Florida 
• University of Florida 
• University of Miami 
• University of South Florida 

In January 2025, when the NSF I-Corps Southeast Hub officially launches, the consortium of schools will expand to include the University of Puerto Rico. Additionally, through Morehouse College’s activation, Spelman College and the Morehouse School of Medicine will also participate in supporting the project. 

With a combined economic output of more than $3.2 trillion, the NSF I-Corps Southeast Hub region represents more than 11% of the entire U.S. economy. As a region, those states and Puerto Rico have a larger economic output than France, Italy, or Canada. 

“This is a great opportunity for us to engage in regional collaboration to drive innovation across the Southeast to strengthen our regional economy and that of Puerto Rico,” said the Enterprise Innovation Institute’s Nakia Melecio, director of the NSF I-Corps Southeast Hub. As director, Melecio will oversee strategic management, data collection, and overall operations​. 

Additionally, Melecio serves as a national faculty instructor for the NSF I-Corps program. 

“This also allows us to collectively tackle some of the common challenges all four of our states face, especially when it comes to being intentionally inclusive in reaching out to communities that historically haven’t always been invited to participate,” he said. 

That means bringing solutions to market that not only solve problems but are intentional about including researchers from Black and Hispanic-serving institutions, Melecio said. 

Keith McGreggor, director of Georgia Tech’s VentureLab, is the faculty lead charged with designing the curriculum and instruction for the NSF I-Corps Southeast Hub’s partners. 

McGreggor has extensive I-Corps experience. In 2012, Georgia Tech was among the first institutions in the country selected to teach the I-Corps curriculum, which aims to further research commercialization. McGreggor served as the lead instructor for I-Corps-related efforts and led training efforts across the Southeast, as well as for teams in Puerto Rico, Mexico, and the Republic of Ireland. 

Raghupathy “Siva” Sivakumar, Georgia Tech’s vice president of Commercialization and chief commercialization officer, is the project’s principal investigator. 

The NSF I-Corps Southeast Hub is one of three announced by the NSF. The others are in the Northwest and New England regions, led by the University of California, Berkeley, and the Massachusetts Institute of Technology, respectively. The three I-Corps Hubs are part of the NSF’s planned expansion of its National Innovation Network, which now includes 128 colleges and universities across 48 states. 

As designed, the NSF I-Corps Southeast Hub will leverage its partner institutions’ strengths to break down barriers to researchers’ pace of lab-to-market commercialization. 

"Our Hub member institutions have successfully commercialized transformative technologies across critical sectors, including advanced manufacturing, renewable energy, cybersecurity, and biomedical fields,” said Sivakumar. “We aim to achieve two key objectives: first, to establish and expand a scalable model that effectively translates research into viable commercial ventures; and second, to address pressing societal needs.

"This includes not only delivering innovative solutions but also cultivating a diverse pipeline of researchers and innovators, thereby enhancing interest in STEM fields — science, technology, engineering, and mathematics.”

U.S. Rep. Nikema Williams, D-Atlanta, is a proponent of the Hub’s STEM component. 

“As a biology major-turned-congresswoman, I know firsthand that STEM education and research open doors far beyond the lab or classroom.,” Williams said. “This National Science Foundation grant means Georgia Tech will be leading the way in equipping researchers and grad students to turn their discoveries into real-world impact — as innovators, entrepreneurs, and business leaders. 

“I’m especially excited about the partnership with Morehouse College and other minority-serving institutions through this Hub, expanding pathways to innovation and entrepreneurship for historically marginalized communities and creating one more tool to close the racial wealth gap.” 

That STEM aspect, coupled with supporting the growth of a regional ecosystem, will speed commercialization, increase higher education-industry collaborations, and boost the network of diverse entrepreneurs and startup founders, said David Bridges, vice president of the Enterprise Innovation Institute. 

“This multi-university, regional approach is a successful model because it has been proven that bringing a diversity of stakeholders together leads to unique solutions to very difficult problems,” he said. “And while the Southeast faces different challenges that vary from state to state and Puerto Rico has its own needs, they call for a more comprehensive approach to solving them. Adopting a region-oriented focus allows us to understand what these needs are, customize tailored solutions, and keep not just our hub but our nation economically competitive.” 

The Institute for Matter and Systems (IMS) held its opening showcase on October 15, 2024, in the Marcus Nanotechnology Building at Georgia Tech. 

“We're trying to link people from fundamental science through materials, measurements, modelling software, systems, economics, and public policy,” said Eric Vogel, IMS executive director.

Vogel noted that IMS does this in four ways— through research support, fabrication and characterization core facilities, education and outreach programs and strategic external engagement.

The Institute for Matter and Systems arose from the union of the Institute of Electronics and Nanotechnology and the Institute for Materials. Each of the latter two interdisciplinary research institutes focused on major national priorities — the National Nanotechnology Initiative and the Materials Genome Initiative, respectively. The work done by IMS researchers flies at the intersection of technology, innovation, and science, with a focus on creating technological and societal transformation through devices, processes and components.

The event featured the second annual Oliver Brand Memorial Lectureship on Electronics and Nanotechnology. The lecture was presented by Michael Strano, whose research focuses on micro-robotics. 

After the lecture, guests were invited to explore IMS’s research centers and facilities. Walking tours of the micro/nano fabrication cleanroom and material characterization facility showcased the core facilities available to those who engage with IMS. Booths featuring IMS supported research centers allowed guests to explore the breadth of research activities happening within the research institute.