Sep. 16, 2025
ATP synthase is an enzyme that has been using phosphate to generate life’s energy for millions of years.

ATP synthase is an enzyme that has been using phosphate to generate life’s energy for millions of years. Nanoclustering/Science Photo Library via Getty Images

The questions of how humankind came to be, and whether we are alone in the universe, have captured imaginations for millennia. But to answer these questions, scientists must first understand life itself and how it could have arisen.

In our work as evolutionary biochemists and protein historians, these core questions form the foundation of our research programs. To study life’s history billions of years ago, we often use clues called molecular “fossils” – ancient structures shared by all living organisms.

Recently, we discovered that an important molecular fossil found in an ancient protein family may not be what it seems. The dilemma centers, in part, on a simple question: What does it mean if a simple molecular structure – the fossil – is found in every single organism on Earth? Do molecular fossils point to the seeds that gave rise to modern biological complexity, or are they simply the stubborn pieces that have resisted erosion over time? The answers have far-reaching implications for how scientists understand the origins of biology.

Follow the Phosphorus to Follow Life

Life is made of many different building blocks, one of the most important of which is the chemical element phosphorus. Phosphorus makes up part of your genetic material, powers complex metabolic reactions and acts as a molecular switch to control enzymes.

Phosphorus compounds – specifically a charged form called phosphate – have a number of unique chemical properties that other biological compounds cannot match. In the words of the pioneering organic chemist F.H. Westheimer, they are chemically able to “do almost everything.”

Their unique combination of stability, versatility and adaptability is why many researchers argue that following phosphorus is key to finding life. The presence of phosphorus both close to home – in the ocean or on one of Saturn’s moons – and in the farthest reaches of our galaxy is strong evidence for the potential for life beyond Earth.

Chemical structure of a nucleotide, made of a phosphate, ribose sugar and base

Phosphate is part of many essential biological molecules, including the building blocks of DNA. Charles Molnar and Jane Gair, CC BY-SA

If phosphorus is so critical to life, how did early biology predating cells first use it?

Today, biological organisms are able to make use of phosphates through proteins – molecular machines that regulate all aspects of life. By binding to proteins, phosphates regulate metabolism and cellular communication, and they serve as a source of cellular energy.

Further, the process of phosphorylation, or adding a phosphate group to a protein, is ubiquitous in biology and allows proteins to perform functions their individual building blocks cannot. Without proteins, the existence of organisms such as bacteria and humans may not be possible.

Given how essential phosphorus is to life, scientists hypothesize that phosphate binding was among the first biological functions to emerge on Earth. In fact, current evidence suggests that the first phosphate-binding proteins are truly ancient – even older than the last universal common ancestor, the hypothetical mother cell to all life on Earth that existed around 4 billion years ago.

A Mysterious Phosphate-Binding Fossil

One family of phosphate-binding proteins, called P-loop NTPases, regulates everything from the communication between cells to the storage of energy and are found across the tree of life. Because P-loop NTPases are among the most ancient protein families, analyzing their properties can provide key insights into both the emergence of proteins and how primitive life used phosphates.

Although P-loop NTPases are diverse in structure, they share a common motif called a P-loop. This component binds to phosphate by wrapping a nest of amino acids – the building blocks that make up proteins – around the molecule. Every known organism has multiple families of P-loop NTPase, which makes the P-loop an excellent example of a molecular fossil that can provide clues about the evolution of life. Our crude analysis of the human genome estimates that humans have about 5,000 copies of P-loops.

When part of a larger protein structure, the P-loop folds like origami into a shape that is ideal for hugging a phosphate molecule. These nests are extremely similar to each other, even when the surrounding proteins are only distantly related in function. A landmark study in 2012 argued that even if the P-loop nest is extracted from a protein, it can still bind to phosphate. In other words, the ability of a P-loop to form a nest is determined by its interactions with phosphate, not its protein scaffold.

This study provided the first evidence that some forms of the P-loop sequence could have functioned billions of years ago, even before the emergence of large, complex proteins. If true, this implies that P-loop nests may have seeded the emergence and evolution of many of the phosphate-binding proteins seen today.

Interrogating the History of the P-loop

The pioneer of bioinformatics, Margaret Oakley Dayhoff, hypothesized in 1966 that the large collection of big proteins seen today arose from small peptides that were duplicated and fused over long periods of time. Although P-loops may have evolved in a different way, Dayhoff’s realization was the first to clarify how complex forms could have arisen from much simpler ones.

Inspired by Dayhoff’s hypothesis, we sought to interrogate the role that simple P-loops may have played in the evolution of the complex proteins key to life. Our findings challenge what’s currently known about these molecular fossils.

Diagram showing the evolution of amino acids to oligopeptides to complex proteins

The Dayhoff hypothesis proposed that large, complex proteins arose from the duplication and merging of smaller, simpler peptides over time. Merski et al./Biomolecules, CC BY-SA

Using computer models, we compared a range of P-loops from the P-loop NTPase family to a control group made of the same amino acids but in a different order. While these control loops are also found in proteins, they do not form nests.

Although the P-loops and the control loops are very different in their nest-forming ability, we found that they both are able to form transient nests when embedded in proteins. This meant that, contrary to popular belief, the amino acid sequence of P-loops aren’t special in their ability to form nests – as would be expected if they alone were the seeds for many modern proteins.

A Fossil Eroded Over Time

Our work strongly suggests that while the P-loop is a molecular fossil, the true nature of its form billions of years ago may have been eroded by the sands of time.

For example, when we repeated our simulations in a different solvent – specifically methanol – we found that P-loops situated in their parent proteins were able to regain some of their ability to form nests. This doesn’t mean that being in methanol drove the first proteins with P-loops to form the nests critical for life. But it does emphasize the importance of considering the surrounding environment when studying peptides and proteins.

Just as archaeologists know to be careful in how they interpret physical fossils, historians of protein evolution could take similar care in their interpretation of molecular fossils. Our results complicate the current understanding of early protein evolution and, consequently, some aspects of the origins of life.

In resetting the field’s broader understanding of how these crucial proteins emerged, scientists are poised to start rewriting our own evolutionary history on this planet.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Authors:

Caroline Lynn Kamerlin, professor of chemistry and biochemistry, Georgia Institute of Technology 

Liam Longo, specially appointed associate professor, Earth-Life Science Institute, Institute of Science Tokyo

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Shelley Wunder-Smith
shelley.wunder-smith@research.gatech.edu

Sep. 16, 2025
Car exhaust (Adobe: elcovalana)

Scientists at Georgia Tech have teamed up with researchers at Johns Hopkins Medicine and Columbia University to better understand how certain types of air pollution increase the risk of developing dementia. 

Their findings, published this month in the journal Science, help explain how small particle pollution — think industrial emissions and car exhaust, wildfires and burning wood for heat and cooking — can lead to Lewy body dementia, a devastating disease that causes toxic clumps of protein to destroy nerve cells in the brain. 

"Epidemiological studies have suggested a strong link between air pollution and dementia, but what sets this study apart is that we also provide a convincing biological mechanism,” says Pengfei Liu, assistant professor School of Earth and Atmospheric Sciences and one of the study’s co-authors. “This collaborative work shows that fine particulate matter from different geographic regions consistently triggers a specific stain of misfolded protein that drives Lewy body dementia." 

The work has “profound implications” for helping scientists and policy makers better understand measures to prevent this type of dementia, which is among the most common forms of the disease and affects millions of people around the world.

Along with Liu, the research team from Georgia Tech includes Rodney Weber, professor in the School of Earth and Atmospheric Sciences; Minhan Park, a postdoctoral research fellow co-advised by Liu and Weber; Bin Bai, a graduate student in Liu’s lab; and Ma Cristine Faye Denna, a graduate student in Weber’s lab.

“Figuring out how exposure to atmospheric aerosols might be linked to dementia, and what mechanisms are involved, is a complex and challenging problem — and as this study shows, it takes a large team with many different areas of expertise,” Weber adds.

Learn more:

 

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Jess Hunt-Ralston
Director of Communications
College of Sciences at Georgia Tech

Sep. 16, 2025
Lukas Berg (right), who flew several variants of the UH-60 Blackhawk over the course of his career, celebrated his final flight before joining the Georgia Tech Manufacturing Institute in August.

Lukas Berg (right), who flew several variants of the UH-60 Blackhawk over the course of his career, celebrated his final flight before joining the Georgia Tech Manufacturing Institute in August.

Berg will be working with GTMI for the course of his fellowship with the Hiring Our Heroes program.

Berg will be working with GTMI for the course of his fellowship with the Hiring Our Heroes program.

Maria Venable, Berg's grandmother, joined the Georgia Tech faculty in 1963 as a 28-year-old native German speaker.

Maria Venable, Berg's grandmother, joined the Georgia Tech faculty in 1963 as a 28-year-old native German speaker.

Berg and his family stand next to the model of helicopter frequently flown during his career.

Berg and his family stand next to the model of helicopter frequently flown during his career.

As the U.S. works to strengthen its industrial base and reshore critical manufacturing capabilities, workforce development has emerged as a central challenge — and opportunity. 

The Georgia Tech Manufacturing Institute (GTMI) recently welcomed its first Hiring Our Heroes (HOH) Fellow to help address this growing need. Lukas Berg, a retiring U.S. Army officer, will be working with GTMI to support new education and training programs aimed at preparing Georgians for careers in advanced manufacturing.

“Lukas Berg brings a unique blend of operational experience, academic insight, and a deep commitment to service,” said Thomas Kurfess, executive director of GTMI. “His perspective will be invaluable as we work to build stronger connections between Georgia’s communities and the advanced manufacturing sector.”

Hiring Our Heroes is a nationwide initiative led by the U.S. Chamber of Commerce Foundation that helps veterans and military spouses transition into civilian careers through short-term fellowships. Since 2021, Georgia Tech has hosted more than two dozen HOH fellows, beginning with U.S. Army veteran Erik Andersen, who now serves as interim deputy director for the Research, Electronics, Optics, and Systems Directorate at the Georgia Tech Research Institute (GTRI), where he also helps lead the HOH program. 

Berg is the first fellow to be placed outside of GTRI, a sign of the program’s growing reach across campus and its potential to support a broader range of workforce development efforts.

“It’s been exciting to see how the Hiring Our Heroes program has grown at Georgia Tech,” said Andersen. “Berg’s placement at GTMI reflects the Institute’s commitment to connecting military talent with real-world innovation and workforce development. Veterans bring a unique perspective and skill set to these challenges, and I’m proud to see the program expanding to new parts of campus.”

Berg’s military career includes aviation command roles, teaching positions at West Point and the Joint Special Operations University, and deployments across multiple regions. At GTMI, he will be contributing to a new initiative that partners with rural school districts to introduce students to hands-on learning in advanced manufacturing, an effort designed to spark interest in high-potential career paths and support long-term workforce readiness.

With personal ties to Georgia Tech and a strong sense of purpose, Berg sees this fellowship as a meaningful next step. We spoke with him to learn more about what brought him to GTMI and how he views the role of manufacturing and workforce development in shaping the country’s future.

What inspired you to pursue a fellowship at the Georgia Tech Manufacturing Institute after your military service?

Last year, I visited Georgia Tech with many of the junior officers and pilots assigned to my helicopter battalion in Savannah. Our agenda included stops at the Georgia Tech Manufacturing Institute and the Advanced Manufacturing Pilot Facility, both of which struck me as being absolutely vital to maintaining the technological edge required to fight and win on the modern battlefield. Pursuing a fellowship at GTMI felt like a natural extension of my military service, and I suspected that it would put me back at the intersection of thinkers and doers (where I have always felt most at home). 

You mentioned your grandmother taught at Georgia Tech for over 30 years — how has her legacy influenced your academic and professional journey?

My grandmother, Maria Venable, was the first woman to serve as a full-time faculty member in Georgia Tech’s School of Modern Languages. She poured herself into both her family and her students, and I was lucky to count myself in both populations, as she agreed to tutor me for the AP German exam in high school (but only if I behaved as well as her students at Tech). Her example inspired me to pursue a teaching assignment at West Point halfway through my Army career, and I experienced the same joy in teaching that she did. It’s something that I will continue to do for the rest of my life, whether in a formal or informal capacity.

Can you share more about the specific initiatives you'll be working on at GTMI related to advanced manufacturing education?

Most immediately, I am joining a new GTMI initiative that partners with rural school districts to deliver several weeks’ worth of curriculum and hands-on practice in advanced manufacturing. We just kicked off a pilot program with Bainbridge High School in Decatur, and it’s exciting to see their students leveraging sophisticated systems to design and build Pinewood Derby cars that would make Cub Scouts across the country green with envy. Beyond this initiative, I hope to contribute to other efforts that get young people excited about careers in manufacturing and that assist adult learners in re-skilling and up-skilling for this high-potential industry.

What are you most looking forward to as you begin your fellowship at GTMI?

Georgia Tech feels like a physical and intellectual crossroads of modern civilization. I’m excited to not only contribute as a member of GTMI but also to learn about the countless other departments, institutes, and programs that are convening talent to solve the world’s thorniest problems. 

What skills or insights are you hoping to gain during your time at GTMI that will support your next career chapter?

As an Army officer, I’ve been stationed across the country and deployed around the world, but Georgia has always been home. (Gladys Knight’s “Midnight Train to Georgia” has been a fixture on my playlist since I left for West Point at the age of 17.) Now back with my family, I look forward to using my time at GTMI to learn about my home state and identify ways that I can contribute to its near and long-term prosperity, whether through roles in academia, government, or private industry. I also look forward to expanding my network in all these communities, as no single one has a monopoly on problem-solving.

Why do you believe rebuilding America’s industrial base and manufacturing workforce is critical to national security today?

As a career aviator, much of my professional life was spent agonizing over the availability of parts to repair my helicopters. It seemed like there were never enough, and they always took too long to get to me. This experience, coupled with lessons learned from our support of Ukraine’s self-defense, contrasted starkly with my recent study of America’s 20th-century role as the “arsenal of democracy.” I’m convinced that we need to regain that reputation, and I would like to see Georgia at the forefront of associated design, manufacturing, and education initiatives.  

How do you see veterans playing a unique role in strengthening the U.S. manufacturing workforce?

I think veterans are the most natural candidates in the world for roles in the manufacturing workforce. They possess the knowledge, skills, and abilities to be successful in most endeavors, but most are looking for ways to extend their service beyond their time in uniform. What better way than to contribute to a field that is so vital to our national security and prosperity?

What does “Progress and Service” mean to you, and what does it mean to you personally to be contributing to that mission?

I love Tech’s motto. I grew up in a family and community that reinforced at every turn the idea that our highest potential as human beings is realized when we serve others. This motivated my choice to serve in the military for the past 20 years, and it remains my North Star for this next chapter. I also love the idea of technological progress being the vehicle by which Georgia Tech collectively serves others, and I hope to accelerate this progress during my time at GTMI. 

If you could give one piece of advice to other service members considering a fellowship like this, what would it be?

Inventory your passions and define your purpose. Then start reaching out to people in related fields. I have been amazed at how generous people have been with their time and how eager they have been to help me find my second calling and related opportunities.

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Audra Davidson
Research Communications Program Manager
Georgia Tech Manufacturing Institute

Sep. 16, 2025
An aerial photo of the SPRUCE experiment.
An arial photo of the SPRUCE experiment.
Postdoctoral Researchers Caitlin Petro and Borja Aldeguer-Riquelme inside a SPRUCE chamber in 2023.

Postdoctoral Researchers Caitlin Petro and Borja Aldeguer-Riquelme inside a SPRUCE chamber in 2023.

Ph.D. student Katherine Duchesneau sampling porewater inside an experimental SPRUCE chamber.
Ph.D. student Katherine Duchesneau sampling porewater inside an experimental SPRUCE chamber.
Postdoctoral Researcher Caitlin Petro, Ph.D. student Katherine Duchesneau, and undergraduate student Sekou Noble-Kuchera in a SPRUCE chamber.

Postdoctoral Researcher Caitlin Petro, Ph.D. student Katherine Duchesneau, and undergraduate student Sekou Noble-Kuchera in a SPRUCE chamber.

Joel Kostka at the SPRUCE experiment.

Joel Kostka at the SPRUCE experiment.

Between a third and half of all soil carbon on Earth is stored in peatlands, says Tom and Marie Patton Distinguished Professor Joel Kostka. These wetlands — formed from layers and layers of decaying plant matter — span from the Arctic to the tropics, supporting biodiversity and regulating global climate.

“Peatlands are essential carbon stores, but as temperatures warm, this carbon is in danger of being released as carbon dioxide and methane,” says Kostka, who is also the associate chair for Research in the School of Biological Sciences and the director of Georgia Tech for Georgia’s Tomorrow. Understanding the ratio of carbon dioxide to methane is critical, he adds, because while both are greenhouse gasses, methane is significantly more potent.

Kostka is the corresponding author of a new study unearthing how and why peatlands are producing carbon dioxide and methane. 

The research, “Northern peatland microbial communities exhibit resistance to warming and acquire electron acceptors from soil organic matter,” was published this summer in Nature Communications, and was led by co-first authors Borja Aldeguer-Riquelme, a postdoctoral research associate in the Environmental Microbial Genomics Laboratory, and Katherine Duchesneau, a Ph.D. student in the School of Biological Sciences.

The study builds on a decade of research at the Oak Ridge National Lab’s Spruce and Peatland Responses Under Changing Environments (SPRUCE) experiment, a long-term research project in Minnesota that allows researchers to warm whole sections of wetland from tree top to bog bottom.

“Over the past 10 years, we’ve shown that warming in this large-scale climate experiment increases greenhouse gas production,” Kostka says. “But while warming makes the bog produce more methane, we still observe a lot more CO2 production than methane. In this paper, we take a critical step towards discovering why — and describing the mechanisms that determine which gases are released and in what amounts.”

Methane mystery

The subdued methane production in peatlands has been a long-standing mystery. In water-saturated wetlands, oxygen is scarce, but microbes still need to respire — a type of ‘breathing’ that allows them to produce energy for metabolic function. Without oxygen, microbes use nitrate, sulfate, or metals to respire — still releasing carbon dioxide in the process. However, if these ingredients aren’t present, microbes ‘breathe’ in a way that releases methane.

Since nitrate, sulfate, and metals are relatively rare in peatlands, methane production should be the most likely pathway, but surprisingly, observations show the opposite. “In both fieldwork and lab experiments, peatlands produce much more carbon dioxide than methane,” Kostka explains. “It’s puzzling because the soil conditions should help methane production dominate.”

To solve this mystery, the team leveraged a suite of cutting-edge genetic tools called “omics” —  metagenomics (studying DNA), metatranscriptomics (studying RNA), and metabolomics (a technique used to study the “leftovers” of metabolism), providing a detailed look under the hood of the microbial “engine” that cycles organic matter in wetlands. It also gave a new window into the diversity of soil microbes in wetlands: 80 percent of the organisms identified in the study were new at the genus level.

‘Omics’ innovations

Over the course of several years, the team collected samples from a peatland enclosed in an experimental chamber that was slowly warmed, then analyzed the samples using omics to see how they changed. Initially, they hypothesized that warming the soil would cause microbial communities to change quickly. “Microbes can evolve and grow rapidly,” Kostka says. “But that didn’t happen.”

The DNA-based methods showed that while the microbial communities stayed largely stable, the bog did release more greenhouse gasses as it warmed. To assess the metabolic potential of the microbes, Duchesneau and Aldeguer-Riquelme constructed microbial genomes, investigating how they were decomposing the organic matter in peatlands and cycling carbon.

“We found that microbial activity increases with warming, but the growth response of microbial communities lags behind these changes in physiological or metabolic activity,” Kostka says. He cautions that this doesn’t necessarily mean that wetland communities won’t change as climates warm — just that these shifts might come behind metabolic ones. 

A diversity of discoveries

And the methane? The team believes that microbes may be breaking down organic matter to access the key ingredients for producing carbon dioxide — nitrate, sulfate, and metals — though more research is currently underway to investigate this.

“Doing this type of integrated omics research in soil systems is still incredibly difficult,” Kostka says. The challenge is multifaceted: the research leverages years of experiments, long-term datasets, advanced laboratory techniques, and fieldwork innovations. 

At SPRUCE, experimental chambers are about 1,000 square feet. While it’s an impressive experimental setup, researchers still must be careful: “We need to take soil samples for many years, so if we take too many, there’d be no soil left!” Kostka explains. “Part of our research involves developing better, non-destructive sampling techniques.”

The other challenge lies in what makes these peatlands so unique: it’s very hard to detect small changes because of the sheer diversity of organisms present. “Every time we conduct this type of research, we learn more about these incredible systems,” he says. “There’s always something new.”

 

DOI: https://doi.org/10.1038/s41467-025-61664-7

Funding: The Office of Biological and Environmental Research, Terrestrial Ecosystem Science Program and Genomic Science programs, under the US Department of Energy (DOE); the Environmental Molecular Sciences Laboratory, a DOE Office of Science User Facility sponsored by the Biological and Environmental Research program. The SPRUCE experiment is funded by the Biological and Environmental Research program in the U.S. Department of Energy’s Office of Science.

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Written by Selena Langner

Sep. 16, 2025
Saad Bhamla

Saad Bhamla, associate professor in Georgia Tech's School of Chemical and Biomolecular Engineering

Saad Bhamla of Georgia Tech’s School of Chemical and Biomolecular Engineering (ChBE) is a member of a global cohort of eight scientists and engineers who were named Schmidt Polymaths. They will each receive up to $2.5 million over five years to pursue research in new disciplines or using new methodologies, Schmidt Sciences announced today.

As Schmidt Polymaths, the researchers pursue new approaches compared to previous work. The new cohort of polymaths will answer questions like how to expand access to healthcare with low-cost technologies, what happens to our chromosomes when we age and how to create more accurate computer simulations of climate. 

Bhamla, associate professor in ChBE@GT, is the first Schmidt Polymath from Georgia Tech. He will develop low-cost technologies to tackle planetary-scale challenges, including AI-enabled point-of-care diagnostics in low-resource environments, and he will also engineer autonomous morphing machines that adapt, evolve and learn like living systems.

The eight selected scientists represent the fifth cohort of the highly selective Schmidt Polymaths program. Awardees must have been tenured—or achieved similar status—within the previous three years. Previous cohorts have used the award to design new sensor devices, perform experiments at atomic resolutions, analyze trees of life with faster and more efficient algorithms, discover new mathematical formulas assisted by AI, and more. 

Drawn from universities worldwide and selected through a competitive application process, Schmidt Polymaths are required to demonstrate past ability and future potential to pursue early-stage, novel research that would otherwise be challenging to fund—even without the current dramatic declines in U.S. funding for science. 

“Our world is one deeply interconnected system---but to study it more deeply, we’ve divided it into increasingly narrow categories,” said Wendy Schmidt, who co-founded Schmidt Sciences with her husband Eric. “Schmidt Polymaths see the bigger picture, pursue answers beyond boundaries and expand the edges of what’s possible.  Their work can help steer  us all toward a healthier  future, for people and the planet.”

About Schmidt Sciences

Schmidt Sciences is a nonprofit organization founded in 2024 by Eric and Wendy Schmidt that works to accelerate scientific knowledge and breakthroughs with the most promising, advanced tools to support a thriving planet. The organization prioritizes research in areas poised for impact including AI and advanced computing, astrophysics, biosciences, climate, and space—as well as supporting researchers in a variety of disciplines through its science systems program.

RELATED: Forbes featured Bhamla in the article: Saad Bhamla Is A Polymath

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Brad Dixon, braddixon@gatech.edu

Sep. 15, 2025
Space shuttle in orbit

Georgia Tech’s Office of Commercialization announces a gift from CreationsVC of $375,000 to accelerate the development of space-related and space-adjacent startup companies based on Georgia Tech intellectual property.

Georgia Tech’s Office of Commercialization’s new Quadrant-i unit focuses on the commercialization of Georgia Tech intellectual property. In combination with Georgia Tech’s consistently top-ranked Daniel Guggenheim School of Aerospace Engineering and its newly formed interdisciplinary Space Research Institute (SRI), Quadrant-i is positioned to dramatically boost the output of space-related spin-offs into a burgeoning Atlanta startup ecosystem. A strategic gift from CreationsVC will support these efforts by creating a pilot program that provides funding for the startup projects of five CreationsVC Fellows per year for three years.

CreationsVC is a venture capital firm that specializes in investing in space tech, AI, and related technologies. CreationsVC sponsors Creation-Space, an Israeli-based global innovation hub that is fostering innovation to enable humanity’s expansion beyond Earth. Steve Braverman, who heads CreationsVC, said the gift is focused on "identifying innovative technologies that support research on life in space, combined with a focus on climate efficiency. This will help improve both expansion of space-centric industry as well as efforts that address challenges on Earth.” 

Braverman said he was attracted to Georgia Tech’s focus on entrepreneurship and its track record in aerospace innovation. “I am impressed with the depth and breadth of technical expertise and energized by the passionate commitment of faculty and students to see their innovations have real-world impact. This gift is intended to supercharge efforts over the next three years to launch several startups that can grow quickly and have impact in Atlanta and Israel.”

Quadrant-i has worked closely with the SRI in its formation and made space commercialization an important and embedded pillar of the new activity. “We are thrilled to work with Steve and the CreationsVC team in identifying and accelerating nascent technologies that will have dual-use value propositions in space, climate, and AI applications,” said Quadrant-i’s director Jonathan Goldman. “We have a fantastic well of innovation from our faculty and graduate students and an amazing fountain of entrepreneurial talent from our CREATE-X program for our undergrads. We are excited to see this relationship blossom.” 

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Anne Stanford 
anne.stanford@dev.gatech.edu

Sep. 10, 2025
Georgia Tech researchers test their prototype of a robotic guide dog. Photo by Terence Rushin/College of Computing.
A graphic depicts design considerations for the prototype.

People who are visually impaired and cannot afford or care for service animals might have a practical alternative in a robotic guide dog being developed at Georgia Tech.

Before launching its prototype, a research team within Georgia Tech’s School of Interactive Computing, led by Professor Bruce Walker and Assistant Professor Sehoon Ha, is working to improve its methods and designs based on research within blind and visually impaired (BVI) communities.

“There’s been research on the technical aspects and functionality of robotic guide dogs, but not a lot of emphasis on the aesthetics or form factors,” said Avery Gong, a recent master’s graduate who worked in Walker’s lab. “We wanted to fill this gap.”

Training a guide dog can cost up to $50,000, and while there are nonprofit organizations that can cover these costs for potential owners, there is still a gap between the amount of available guide dogs and BVI individuals who need them. Not all BVI individuals are able to care for a dog and feed it. The dog also has fewer than 10 working years before it needs replacement.

Gong co-authored a paper on the design implications of the robotic guide dog that was presented at the 2025 International Conference on Robotics and Automation (ICRA) in Atlanta in May.

The consensus among the study’s participants indicates they prefer a robotic guide dog that:

  • resembles a real dog and appears approachable
  • has a clear identifier of being a guide dog, such as a vest
  • has built-in GPS and Bluetooth connectivity
  • has control options such as voice command
  • has soft textures without feeling furry
  • has long battery life and self-charging capability

“A lot of people said they didn’t want the dog to look too cute or appealing because it would draw too much attention,” said Aviv Cohav, another lead author of the paper and recent master’s graduate.

“Many people have issues with taking their guide dog to places, whether it’s little kids wanting to play with the dog or people not liking dogs or people being scared of them, and that reflects on the owners themselves. We wanted to look at what would be a good balance between having a functional robot that wouldn’t scare people away or be a distraction.”

The researchers also had to consider the perspectives of sighted individuals and how society at large might view a robotic guide dog.

An example of this is the amount of noise the dog makes while walking. The owner needs to hear the dog is active, but the clanky sound many off-the-shelf robots make could create disturbances in indoor spaces that amplify sounds. To offset the noise, the team developed algorithms that allow the robot to move more quietly.

Walker and his lab have examined similar scenarios that must take public perception into account.

“We like to think of Georgia Tech as going the extra mile,” Walker said. “Let’s not just make a robot, but a robot that’s going to fit into society.

“To have impact, the technologies we produce must be produced with society in mind. This is a holistic design that considers the users and all the people with whom the users interact.”

Taery Kim, a computer science Ph.D. student, began working on the concept of a robotic guide dog when she came to Georgia Tech in 2022. She and Ha, her advisor, have authored papers on building the robot’s navigation and safety components. 

“When I started, I thought it would be as simple as giving the guide dog a command to take me to Starbucks or the grocery store, and it would just take me,” Kim said. “But the user must give waypoint directions — ‘go left here,’ ‘turn right,’ ‘go forward,’ ‘stop.’ Detailed commands must be delivered to the dog.”

While a real dog has naturally enhanced senses of hearing and smell that can’t be replicated, technology can provide interconnected safety features during an emergency. The researchers envision a camera system equipped with a 360-degree field of view, computer vision algorithms that detect obstacles or hazards, and voice recognition that recognizes calls for help. An SOS function could automatically call 911 at the owner’s request or if the owner is unresponsive.

Kim said the robot should also have explainability features to enhance communication with the owner. For example, if the robot suddenly stops or ignores an owner’s commands, it should tell the owner that it’s detecting a hazard in their path.

Manufacturing a robot at scale would initially be expensive, but the researchers believe the cost would eventually be offset because of its longevity. BVI individuals may only need to purchase one during their lifetime.

To introduce a prototype, the multidisciplinary research team recognizes that it needs to enlist experts from other fields to adequately address the various implications and research gaps inherent in the project.

Walker said the teams welcome additional partners who are keen to tackle challenges ranging from design and engineering to battery life to human-robot interaction.

Team member J. Taery Kim was supported by the National Science Foundation's Graduate Research Fellowship Program (NSF GRFP) under Grant No. DGE-2039655.

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Nathan Deen, Communications Officer
School of Interactive Computing

nathan.deen@cc.gatech.edu

Sep. 09, 2025
Headshots of Matthew McDowell and Ryan Lively

Headshots of Michael McDowell and Ryan Lively

Two Georgia Tech researchers in the College of Engineering have been named finalists for the 2025 Blavatnik National Awards for Young Scientists. Their discoveries, which could create cleaner industrial processes and safer, more reliable batteries, have important potential impacts for daily life. 

The Blavatnik Awards are presented by the Blavatnik Family Foundation and are administered by the New York Academy of Sciences. They honor the most promising early-career researchers in the U.S., across life sciences, chemistry, and physical sciences, and engineering. The awards are among the most prestigious and competitive in science.  

This dual recognition underscores Georgia Tech’s growing national leadership in high-impact, interdisciplinary research. 

Ryan Lively, Thomas C. DeLoach Jr. Endowed Professor in the School of Chemical and Biomolecular Engineering, is recognized in the Chemical Sciences category for pioneering scalable technologies that will reduce industrial carbon emissions and energy use. He develops new materials that can capture carbon and separate chemicals, using much less energy than conventional methods. His innovations could make industry cleaner and play a key role in addressing climate change. 

Matthew McDowell, Carter N. Paden Jr. Distinguished Chair in the George W. Woodruff School of Mechanical Engineering holds a joint appointment in the School of Materials Science and Engineering. Recognized in the Physical Sciences and Engineering category for groundbreaking battery research, he and his team develop new materials to make batteries last longer and store more energy. He has discovered ways to visualize how battery materials change during use — insights that help improve the performance and safety of future energy technologies. 
 
This year’s 18 finalists were selected from 310 nominees. On Oct. 7, 2025, three laureates will be announced at a gala at New York City’s American Museum of Natural History. Each laureate will receive $250,000, the largest unrestricted scientific prize for early-career researchers in the U.S.  

 

News Contact

Shelley Wunder-Smith  shelley.wunder-smith@research.gatech.edu

Sep. 04, 2025
Drawdown dashboard

Electric vehicles. Rooftop solar. Cycling to work. Knowing where to start when reducing your personal carbon footprint can be daunting. But a new tool from Georgia Tech makes it easier for anyone to figure out how they can help address climate change.

The Drawdown Georgia Solutions Tracker is a digital dashboard that enables everyday Georgians to see how effective various technologies could be for each county. The tracker analyzes public data for 16 solutions — from planting trees to public transit — that can lower greenhouse gas emissions. The tracker is equally essential for policymakers and business leaders, enabling them to identify opportunities to propose legislation or adjust operations to reduce carbon emissions.

To use the tracker, viewers click on a solution to see its impact. Then, they specify a particular county, and the data is tailored to the most relevant metric. For example, if someone picks “plant-based diet” as a solution, they can see how many vegan restaurants are already in their county. The tracker also contrasts the climate solution with a relevant area that might benefit if the solution is implemented. For the plant-based example, the tracker compares it to urban density. 

This tracker is one of the many initiatives of Drawdown Georgia, one of the Ray C. Anderson Foundation’s key funding initiatives based on research conducted by Georgia Tech, Georgia State University, the University of Georgia, and Emory University. Drawdown Georgia's goal is to reduce Georgia’s carbon impact by 57% by 2030 and to accelerate Georgia’s progress toward net-zero greenhouse emissions. 

Drawdown Georgia also developed a carbon emissions tracker that shows carbon emission levels by county. The dashboard was a success, but the Drawdown Georgia team wanted to create a more proactive tool. The Solutions Tracker was designed so that anyone could make smalldaily changes to improve the climate — not just track it.

“We began the Drawdown Georgia project with the goal of cutting state pollution significantly,” said Marilyn Brown, Regents' Professor and the Brook Byers Professor of Sustainable Systems in the Jimmy and Rosalynn Carter School of Public Policy. "To get Georgians involved, we decided to focus on local and regional opportunities to reduce emissions.”

Drawdown Data

The data combines federal and state sources from the U.S. Energy Information Administration, the National Renewable Energy Laboratory, and the Department of Agriculture. Some solutions may seem obvious, like planting trees, but others are more niche. For example, decomposing trash often produces methane gas, which means that landfills contribute to greenhouse gas emissions — important information for policymakers to consider when developing carbon reduction strategies. 

The researchers hope everyone will use the tracker. Politicians and policymakers can find new ideas for legislation or the adoption of these solutions. Business leaders can find opportunities to hit their decarbonization goals. Georgians can use the tracker to figure out which solutions are most sustainable for their lives. Even scientists can learn which methods to home in on for their research. Since the tracker is available via Creative Commons, anyone can use the data to build their own tools or models. 

The tracker is already having a real-world impact. Brown and the Drawdown Georgia team have collaborated with the state of Georgia and the 29-county metro Atlanta area on their carbon action plans. They’ve also partnered with 75 businesses on carbon action plans and other solutions through the Drawdown Georgia Business Compact, managed by the Ray C. Anderson Center for Sustainable Business in the Scheller College of Business. As these stakeholders ask questions about different climate solution impacts, the team has expanded the tracker accordingly. They’ve also recently redesigned the user interface to make it even more accessible for everyday users.

From improved public health to business opportunities, the state requires reduced greenhouse gases, and Georgia Tech is not only tracking emissions but helping to fix the problem, too.

News Contact

Tess Malone, Senior Research Writer/Editor

tess.malone@gatech.edu

Sep. 02, 2025
Default Image: Research at Georgia Tech

Georgia Tech’s Georgia Manufacturing Extension Partnership (GaMEP) helped transform The Chai Box—a family‑run business born in Marietta—into a nationally recognized brand by guiding them through rigorous food safety audits for retailers like Costco, streamlining production, and boosting their revenue by 20 %. This collaboration not only enabled larger scale success and a feature in Forbes, but vividly illustrated how applied research can turn cultural legacy into commercial opportunities.
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