It’s uncommon for any startup to receive the Food and Drug Administration’s (FDA) Breakthrough Devices designation. For the roughly 40% of applicants who receive the designation, it shows that the technology has real potential to improve patient outcomes and should get priority attention from the agency. 

The Advanced Technology Development Center (ATDC) in Georgia Tech’s Office of Commercialization announced two of its health technology (HealthTech) portfolio companies, Nephrodite and OrthoPreserve, earned the designation. 

Achieving this rare milestone underscores the caliber of founders, science, and support in ATDC’s 30-company HealthTech portfolio, the incubator’s largest focus area. It’s also a win for Georgia because it reflects the strength of the state’s health innovation ecosystem. 

“This designation is one of the strongest signals the FDA gives that a technology could change the standard of care,” said Greg Jungles, HealthTech catalyst at ATDC. “For ATDC to have two in the same year is remarkable.” 

The Breakthrough Device Program doesn’t waive evidence requirements, but it accelerates learning with the FDA, ATDC’s Jungles said. “That means shorter response times, more frequent meetings, and prioritized review. Teams avoid dead ends and align earlier on study designs and endpoints.” 

For the founders of both startups, their technologies come one step closer to moving their innovations to market. Nephrodite’s technology improves the lives of dialysis patients. OrthoPreserve’s device addresses challenges faced by those who suffer from chronic knee pain. 

Nephrodite: Advancing Continuous Artificial Kidney Technology 

Dr. Nikhil Shah and Dr. Hiep Nguyen, cofounders of Nephrodite, aim to improve care for dialysis patients with end-stage kidney disease who need transplants. These patients often spend three to four hours in a dialysis clinic up to three times a week. Being tethered to stationary machines with needles drawing blood via arm grafts complicates everyday activities — from work tasks to the ability to travel. 

Dialysis addresses chronic kidney disease, which means kidneys no longer work properly. The treatments filter out toxins, waste, and other fluids in the blood. Kidney disease costs Medicare $124.5 billion every year, according to the Centers for Disease Control and Prevention. And those costs are expected to rise because of increasing rates of kidney failure and chronic kidney disease. 

“Dialysis, while lifesaving when it was pioneered in 1952, is incredibly burdensome,” Shah said. Besides being a long process that keeps the patient in a fixed location, it’s physically tiring. “Taking out your blood continually many, many times over, and over the course of four hours is the equivalent of running the Boston Marathon, hitting the finish line, and then someone saying, ‘You're not done; go do it again,’ ” he said. 

A surgeon by training, with expertise in transplantation and oncology, Shah is also an adjunct associate professor in Tech’s School of Interactive Computing. He worked with Nguyen to develop a continuously functioning mechanical artificial kidney, leading to Nephrodite’s formation. 

The FDA’s breakthrough designation on its artificial kidney allows the company to pursue approvals to begin tests in human trials. 

The company traces its beginnings to a German aerospace facility outside Munich, where Nguyen and Shah watched engineers demonstrate a pediatric artificial heart — the Berlin Heart. 

“That’s how we got started,” Shah said. “Seeing an artificial heart that led us to think about doing this for kidneys — because the kidney space has been largely ignored for 70 years.” 

Backed by a German federal grant, Nephrodite grew, moving from Germany to Boston, Massachusetts, then to Austin, Texas, before calling Atlanta home. The company joined ATDC and tapped into other Georgia Tech programs. This included the Center for MedTech Excellence and the Georgia Manufacturing Extension Partnership. Nephrodite also drew on student talent as the researchers quietly worked on their continuous mechanical artificial kidney. 

Nephrodite began interviewing patients to find out what they wanted the artificial kidney needed to solve. 

They learned patients want the ability to be mobile. Patients also desire an alternative therapy to large needles being inserted into arm grafts because the injection sites are prone to infection and the grafts can fail. In addition, the process can be painful and disfiguring. Finally, patients want a quality of life independent of machines. 

“Those quality-of-life needs, especially being free and mobile, were absolutely universal,” Shah said.  

Nephrodite began developing the technology to build its device — a filter surgically implanted in the pelvis area. 

“We developed an implant designed to run constantly, connected to larger blood vessels in the pelvis to avoid arm graft failures, and paired with an external interface that lets patients sleep at night while the system removes toxins and excess fluid,” Shah explained. 

The device also has built-in sensors, with data uploaded to the cloud, enabling medical care teams to remotely monitor their patients while freeing patients from frequent in-clinic visits. 

Shah said Nephrodite’s device could restore everyday independence, while potentially lowering infection risk. 

“It's like having an actual kidney, but without all the issues of an unhealthy one,” Shah said.  

OrthoPreserve: Innovating a Minimally Invasive Meniscus Implant 
 
OrthoPreserve’s technology aims to address issues from people have with their meniscus, the C‑shaped piece of cartilage in a knee joint that acts as a shock absorber between the thigh bone and shin bone. 

Though patients undergo a now-routine surgery to address it, incomplete recoveries are also common. An estimated quarter of patients later experience recurring knee pain. No FDA-approved implant currently exists for this population. Now, OrthoPreserveis developing a minimally invasive, artificial meniscus implant to restore cushioning, relieve pain, and delay — or even prevent — knee replacement for some patients. 

“There are a million meniscus surgeries every year, and 25% of those patients still live with recurring pain,” said Jonathan Schwartz, OrthoPreserve’s founder and CEO. 

Patients can face daily pain from ordinary activities, such as prolonged standing or walking a dog. Other activities like jogging and recreational sports can trigger flares that can lead to swelling and prolonged discomfort, Schwartz said. “Those patients have no reliable options today,” he said. “We’re building a minimally invasive implant to restore cushioning and help people get back to the activities they love.” 

OrhoPreserve’s durable implant restores cushioning, and it could help people return to normal activities and delay invasive knee replacement. Along with this comes potential cost and recovery benefits for the healthcare system.   

Schwartz created the implant as his Georgia Tech master’s thesis in the lab of David Ku in the Lawrence P. Huang Endowed Chair for Engineering Entrepreneurship and Regents' Professor in the George W. Woodruff School of Mechanical Engineering. After industry experience, Schwartz returned to further develop the technology, building on Georgia Tech’s translational expertise 

OrthoPreserve has completed mechanical testing and a successful study. The company is raising a $2 million seed to complete validations and begin human trials, which Schwartz expects to start in 18 months. 

“The FDA breakthrough designation validates that nothing like this technology exists, and that it has the potential to disrupt the standard of care,” Schwartz said, adding the U.S.’ market opportunity is roughly $1.5 billion. “We finally have a minimally invasive option to bridge the gap between meniscus surgery and knee replacement.” 

What FDA Breakthrough Designation Means for ATDC’s HealthTech Startups 

Having a faster and clearer path is a derisking milestone for investors who are evaluating capital intensive medical device technologies, Jungles said. 

“This breakthrough device designation is a really big deal for medical device companies,” Jungles said, adding that startups often fear navigating the FDA approval process. “But this designation adds to the legitimacy of their technologies and the problemsthey are solving. The designation will help them get to market faster, assuming their data continues to meet expectations.” 

ATDC launched its HealthTech vertical in 2018, which is now sponsored by Catalyst by Wellstar ATDC’s HealthTech portfoilo companies include medical devices, biotech, and digital health, among other segments. 

ATDC’s Role in Accelerating HealthTech Innovation 

Nephrodite and OrthoPreserve’s founders noted ATDC’s coaching and programming as critical in navigating fundraising and regulatory milestones. Another factor, they said, was ATDC’s connection to Georgia Tech’s labs and facilities and prototyping support and clinical advisors from across metro Atlanta.  

“We meet with ATDC coaches every two to four weeks to troubleshoot and plan,” Schwartz said. “Having that level of seasoned guidance, all without consultant-level costs, has been huge.” 

Jungles added that two Breakthrough device designations in the same year reflects ATDC’s selection rigor, noting he’s evaluated hundreds of technologies since the HealthTech vertical launched. 

“It reflects the caliber of the companies in ATDC, specifically in the medical device space,” Jungles said. “It’s the strength of their teams, the persistence of the founders, and the collaboration of the ecosystem in Georgia and Atlanta.” 

 

Since 2020, Georgia Tech has partnered with Sandia National Laboratories, a federally funded research and development center focused on national security. In February, the two institutions renewed their collaboration with a new Memorandum of Understanding (MOU), reaffirming a relationship that has already strengthened research capabilities on both sides.

The partnership has driven progress in areas ranging from hypersonics to bioscience, while also deepening institutional ties beyond research. Joint faculty appointments — such as Anirban Mazumdar, who holds roles at both Sandia and the George W. Woodruff School of Mechanical Engineering — demonstrate how closely the organizations work together. The collaboration has also expanded student talent pipelines, providing more avenues for Georgia Tech students to pursue careers at the national lab.

“At its core, this partnership is about people,” said Tim Lieuwen, executive vice president for Research at Georgia Tech. “Sandia and Georgia Tech share a commitment to discovery and developing the talent, creativity, and collaboration our nation needs.”

The renewed MOU, he said, “strengthens connections between our researchers, opens new doors for our students, and builds meaningful career pathways into national service. When our communities work together to address national priorities, we not only accelerate technological advances — we expand opportunities for the people who will shape the future of our nation’s security.”

Under the new MOU, Sandia and Georgia Tech will focus on integrated research across key national security‑aligned areas, including secure artificial intelligence and computing, quantum technologies, critical minerals, advanced manufacturing, energy and grid resilience, and hypersonics. The partnership emphasizes connecting manufacturing, computation, and systems approaches directly to national security applications.

“Together, we have been solving new and unprecedented challenges in science and engineering, and now we have a great opportunity to develop this partnership,” said Dan Sinars, Sandia’s deputy chief research officer. “Our research benefits both national security and national prosperity, and keeps the country at the forefront of the world.”

With this strengthened connection, the partners aim to grow their shared research footprint through increased funding, publications, and faculty-led startups. Over the long term, Georgia Tech intends to become one of Sandia’s top hiring pipelines, ensuring that talent developed through joint research continues into national security careers.

History of the Partnership

The Institute’s collaboration with Sandia began in the mid‑2010s, when the labs selected Georgia Tech as one of its partner institutions. The first MOU, signed in 2015, formalized the relationship and outlined initial technical focus areas. 

In 2018, George White, executive director of strategic partnerships, and Olof Westerstahl,  senior director strategic initiatives in the Office of Corporate Engagement, helped expand the partnership. They launched “Sandia Day,” an event designed to introduce Georgia Tech faculty to Sandia researchers and spark new collaborations. By 2020, the organizations signed a second MOU that expanded the partnership’s technical focus areas to include energy and grid security, materials and nanotechnology, advanced electronics, advanced manufacturing, advanced computing, cyber and information security, bioscience, hypersonics, quantum information science, and engineering sciences.

The results have been substantial. Since 2018, Sandia has sponsored $35 million in research collaborations with Georgia Tech. Researchers from both institutions have co-authored 450 publications since 2016. Research activity continues to accelerate, with $1.6 million in new contracts in the past year alone. As of August 2025, Sandia employs 325 Georgia Tech alumni — a testament to the impact of the growing talent pipeline.

“We view our work with Sandia as the model for engagement with other national labs,” said White. “With the new MOU, we will continue to grow the Sandia partnership. I would like to see our footprint double in scope in the next five years.”

 

Georgia Tech’s faculty startup engine Quadrant-i, together with the Space Research Institute (SRI), launched the first cohort of the CreationsVC Space Fellows Program. Funded by space technology venture capital firm CreationsVC, the program enables faculty to explore promising early-stage innovations and their potential for future commercial impact. 

“This first set of CreationsVC Fellows offers an exciting cross-section of innovative hardware and software technologies built on Georgia Tech’s legacy of space exploration, hardware development, and product commercialization,” said Jud Ready, SRI executive director. 

In the first year of the three-year program, CreationsVC provides $125,000 to promote and accelerate innovations that have both space and terrestrial applications. The series offers participants training focused on customer discovery, engaging and compelling storytelling, value proposition design and quantification, and lean/agile project/product management.

“CreationsVC is centered on a deep appreciation for innovation and big thinking,” said Steve Braverman, co-founder and managing partner of CreationsVC. “We felt this was the right time to align our efforts in sourcing and supporting dual-value technologies that will have an impact on both Earth and space.” 

The six startups tackle real-world space research problems like supply chain management, how artificial intelligence works in space, and navigation.

“We are excited CreationsVC is providing us with an opportunity to try new approaches to accelerate deep tech development,” said Jonathan Goldman, Quadrant-i’s director. “These are the toughest kinds of startups to build, and we look forward to the learning we will gain from forcing our innovators out of their comfort zones to embrace some new and valuable skills.”

Meet the cohort:
 

Company: CIMTech.ai
 

Founders: Shimeng Yu, James Read

School: School of Electrical and Computer Engineering (ECE)

Objective: To develop energy-efficient, radiation-tolerant artificial intelligence processors using a persistent type of ferroelectric memory. The startup aims to improve applications requiring high power efficiency, such as battery-powered devices and space-based systems.

Why Q-i: “The advantage of Q-i is in helping technical founders turn their research into products that solve customers’ problems,” noted James Read. “For us, that means talking with potential customers and hearing their pain points directly from the source. Now we’re use that information to build a convincing narrative around our startup’s value for stakeholders and investors.” 

Company: SkyCT
 

Founders: Morris Cohen, Matthew Strong

School: ECE

Objective: To provide up-to-date mapping of the electrical properties of the upper atmosphere, with applications to GPS-free navigation, long-range communication, and satellite and launch vehicle viability. The startup uses the radio energy released by lightning strikes to create this map. 

Why Q-i: “This weird region about 50 miles up from Earth’s surface is both really hard to track and measure, and also impacts a surprising array of applications,” said Cohen. “It’s sometimes called the `ignorosphere’ because of how difficult it is to measure, and it’s time we change that.” 

Company: Penumbra Autonomy
 

Founders: Panagiotis Tsiotras, Juan Diego Florez-Castillo, Iason Velentzas 

School: Daniel Guggenheim School of Aerospace Engineering (AE)

Objective: To commercialize algorithms that help spacecraft maneuver when they have limited information on their environment. The algorithms use state-of-the-art computer vision and localization techniques. This could benefit manufacturing, assembly, and refueling in orbit, as well as enable monitoring, situational awareness, and debris removal. 

Why Q-i: “The program offers a conduit to entrepreneurship opportunities and spinoff companies in the space domain by providing guidance and commercialization ‘know-how,’” said Panagiotis Tsiotras. 

Company: TerraMorph

 
Founders: Yashwanth Kumar Nakka, Sadhana Kumar, Vincent Griffo, Sachin Kelkar

School: AE

Objective: To create an autonomous rover platform with adaptive, reconfigurable mobility. The rover will implement software and sensing algorithms to automatically detect terrain type and improve traction and energy usage. This could be used on the moon or Mars, or even terrestrial search and rescue. 

Why Q-i: “TerraMorph was developed to address fundamental challenges in mobility and autonomy across uncertain terrain,  but successfully translating that work into impact requires creative guidance, critical feedback, and experienced perspectives beyond the lab,” said Yashwanth Kumar Nakka. “Q-i’s culture of leading by example and fostering strong, ethical teams aligns closely with how we want to build TerraMorph: iteratively, thoughtfully, and with a focus on real-world deployment.” 

Company: OpenWerks
 

Founders:  Shreyes Melkote, Mike Yan

School: George W. Woodruff School of Mechanical Engineering

Objective: To deliver real-time manufacturing supply chain visibility for the space and national security industries. OpenWerks technology aims to dramatically reduce current sourcing cycles from eight months down to weeks by connecting corporate buyers directly with verified supplier manufacturing capability and capacity data. 

Why Q-i: “From the very beginning, principals at VentureLab and  Q-i offered a clear pathway to translate academic research into a viable business,” said Mike Yan. “Their reputation for guiding Georgia Tech startups through both business and technology derisking, combined with their comprehensive ecosystem of programs and coaches, made them the natural partner for our entrepreneurial journey.”

Company: 8Seven8
 

Founders: Chandra Raman

School: School of Physics

Objective: To manufacture quantum hardware in Georgia. 8Seven8 aims to put high-precision atomic clocks and gyroscopes on a chip for applications ranging from aircraft navigation to industrial automation.  

Why Q-i: “They have mentored me and my students through the commercialization process, providing opportunities such as the Space Fellows Cohort,” Chandra Raman said. “One of my former students, Alexandra Crawford, gained valuable business experience through a Q-i entrepreneur’s assistantship, and is now working at 8Seven8 full-time. They have also guided me through the process of obtaining funding through the Georgia Research Alliance for our commercialization effort.”

Five faculty members from Georgia Tech have been elected as senior members of the National Academy of Inventors (NAI). As members, they are recognized as distinguished academic inventors with a strong record of patenting technologies, licensing IP, and commercializing their research. Their innovations have made, or have the potential to make, meaningful impacts on society. 

 “The election of our faculty members to this prestigious association is a powerful affirmation of the innovative research happening at Georgia Tech,” said Raghupathy “Siva” Sivakumar, chief commercialization officer at Georgia Tech. “Their work to take research to market reflects the growing importance of invention in addressing society’s most complex challenges. This recognition signals the strength of the commercialization ecosystem at Georgia Tech to advance impactful research, encourage innovation, and prepare the next generation of inventors.” 

The 2026 Georgia Tech NAI senior members are: 

• Jason David Azoulay, associate professor, School of Materials Science and Engineering School and School of Chemistry and Biochemistry
• Jaydev Prataprai Desai, professor and cardiovascular biomedical engineering distinguished chair, Wallace H. Coulter Department of Biomedical Engineering
• David Frost, Elizabeth and Bill Higginbotham Professor and Regents’ Entrepreneur, School of Civil and Environmental Engineering
• Chandra Raman, Dunn Family Professor of Physics, School of Physics
• Aaron Young, associate professor, George W. Woodruff School of Mechanical Engineering

Jason David Azoulay

Azoulay is recognized for pioneering new classes of functional materials through innovative polymer synthesis, heterocycle chemistry, and polymerization reactions. His work spans electronic, photonic, and quantum materials, device fabrication, and chemical sensing for environmental monitoring. He has demonstrated new classes of organic semiconductors with infrared functionality and holds nine issued U.S. patents. Azoulay is the Georgia Research Alliance Vasser-Woolley Distinguished Investigator and holds a joint appointment in the School of Chemistry and Biochemistry. 

Jaydev Prataprai Desai

Desai is recognized for advancing medical robotics and translational biomedical innovation with inventions spanning robotically steerable guidewires for endovascular interventions, minimally invasive surgical tools, MEMS sensors for cancer diagnosis, and rehabilitation robotics for people with motor impairments. He is the founding editor-in-chief of the Journal of Medical Robotics Research, has authored more than 225 peer-reviewed publications, and serves as the Director of Georgia Center for Medical Robotics at Georgia Tech. Desai holds 15 U.S. and International patents.  

David Frost

Frost has built a career at the intersection of civil engineering research and entrepreneurship. A leader in the study of natural and human-made disasters and their impacts on infrastructure, he has founded two Georgia Tech-based software companies: Dataforensics, which offers tools for subsurface data collection and infrastructure project management, and Filio, an AI-powered mobile platform that supports visual asset management in construction and post-disaster reconnaissance. In 2023, Frost was named a Regents’ Entrepreneur by the University System of Georgia’s Board of Regents, a designation reserved for tenured faculty who have successfully taken their research into a commercial setting. He holds four U.S. patents.  

Chandra Raman

Raman is a physicist, inventor, and technology entrepreneur whose research on ultracold atoms is enabling a new generation of ultraprecise quantum sensing devices. He is the co-inventor of chip-scale atomic beam technology — a breakthrough that makes it possible to miniaturize quantum sensors for navigation and timing applications in environments where GPS fails, with uses spanning autonomous vehicles, aerospace, and national security. Raman holds six U.S. patents, three of which have been issued and two licensed. To bring his inventions to market, he founded 8Seven8 Inc., Georgia’s first quantum hardware company. He is a fellow of the American Physical Society and an advisor to national and space-based quantum initiatives. 

Aaron Young

Young directs the Exoskeleton and Prosthetic Intelligent Controls Lab, where he develops robotic exoskeletons and intelligent control systems to improve walking function and physical capability for people with mobility impairments and industrial safety applications. His research has been supported by major federal grants from the National Institutes of Health, and he holds three U.S. patents. Young works with Georgia Tech’s Office of Technology Licensing and Quadrant-i to advance promising technologies toward real-world adoption. 

About Georgia Tech’s Office of Commercialization 

The Office of Commercialization is the nexus of research commercialization and entrepreneurship at Georgia Tech, bringing leading-edge research and innovation to market. It comprises six key units — ATDC, CREATE-X, VentureLab, Quadrant-i, Technology Licensing, and Velocity Startups — that empower students and faculty to launch startups, manage intellectual property, and transform research ideas into positive societal impact. Learn more at commercialization.gatech.edu. 

About the National Academy of Inventors 

The National Academy of Inventors is a member organization comprising U.S. and international universities, and governmental and nonprofit research institutes, with over 4,000 individual inventor members and fellows spanning more than 250 institutions worldwide. It was founded in 2010 to recognize and encourage inventors with patents issued from the U.S. Patent and Trademark Office, enhance the visibility of academic technology and innovation, and translate the inventions of its members to benefit society. Learn more at academyofinventors.org. 

ATLANTA (Feb. 12, 2026) -- The National Academy of Inventors (NAI) has ranked Georgia Tech among the top 20 universities worldwide for U.S. utility patents granted in 2025. The Institute climbed to No. 19 internationally and 13 nationally as a result of its technology licensing office generating 128 patents. The recognition underscores the Institute’s success in moving research breakthroughs from the laboratory into the commercial marketplace, reflecting a coordinated intellectual property (IP) strategy that supports faculty, staff, and student inventors. 

“Our global ranking is a testament to the culture of research innovation we are fostering at Georgia Tech,” said Raghupathy “Siva” Sivakumar, Georgia Tech’s vice president of Commercialization and chief commercialization officer. “Our goal is to ensure that every breakthrough in the lab has a clear, protected pathway to become a startup or product that changes lives. Breaking into the top 20 for the first time demonstrates the impact of our commercialization ecosystem in taking IP to market.” 

Over the past five years, Georgia Tech has shown steady growth in its patent output, issuing more than double the number of patents as in 2020. With utility patents as a key indicator of bench-to-market success, they serve as the legal foundation for licensing agreements, industry partnerships, and the launch of new ventures. Through Technology Licensing at Georgia Tech, researchers receive guidance on disclosure, patent strategy, and protection pathways that help translate research outcomes into real-world applications.

“Our team’s mission is to serve as the gateway to smoothly transfer technologies from the lab to the real world,” said Mary Albertson, director of Technology Licensing at Georgia Tech. “By partnering with researchers early in the discovery process and navigating the complexities of patent protection, we help ensure Georgia Tech innovations are positioned for meaningful economic and societal impact.”

Released annually since 2013, the Top 100 Worldwide Universities Granted U.S. Utility Patents ranking highlights the critical role academic institutions play in the global innovation ecosystem. Through the translation of research into protected technologies, these institutions advance societal progress, while strengthening national and global economies.

Mechanical engineer David McDowell is among the newest members of the National Academy of Engineering (NAE), the organization announced Feb. 10.

McDowell is one 130 new members and 28 international members in the 2026 class. Election to the NAE is among the highest professional recognitions for engineers and an honor bestowed on just 2,900 professionals worldwide. New members are nominated and voted on by the Academy’s existing membership.

McDowell is Georgia Tech’s 50th NAE member. He is Regents’ Professor Emeritus in the George W. Woodruff School of Mechanical Engineering and the School of Materials Science and Engineering.

Read the full story about McDowell on the College of Engineering website.