The U.S. pulp and paper industry uses large quantities of water to produce cellulose pulp from trees. The water leaving the pulping process contains a number of organic byproducts and inorganic chemicals. To reuse the water and the chemicals, paper mills rely on steam-fed evaporators that boil up the water and separate it from the chemicals.

Water separation by evaporators is effective but uses large amounts of energy. That’s significant given that the United States currently is the world’s second-largest producer of paper and paperboard. The country’s approximately 100 paper mills are estimated to use about 0.2 quads (a quad is a quadrillion BTUs) of energy per year for water recycling, making it one of the most energy-intensive chemical processes. All industrial energy consumption in the United States in 2019 totaled 26.4 quads, according to Lawrence Livermore National Laboratory. 

An alternative is to deploy energy-efficient filtration membranes to recycle pulping wastewater. But conventional polymer membranes — commercially available for the past several decades — cannot withstand operation in the harsh conditions and high chemical concentrations found in pulping wastewater and many other industrial applications. 

Georgia Institute of Technology researchers have found a method to engineer membranes made from graphene oxide (GO), a chemically resistant material based on carbon, so they can work effectively in industrial applications. 

“GO has remarkable characteristics that allow water to get through it much faster than through conventional membranes,” said Sankar Nair, professor, Simmons Faculty Fellow, and associate chair for Industry Outreach in the Georgia Tech School of Chemical and Biomolecular Engineering. “But a longstanding question has been how to make GO membranes work in realistic conditions with high chemical concentrations so that they could become industrially relevant.” 

Using new fabrication techniques, the researchers can control the microstructure of GO membranes in a way that allows them to continue filtering out water effectively even at higher chemical concentrations.

The research, supported by the U.S. Department of Energy-RAPID Institute, an industrial consortium of forest product companies, and Georgia Tech’s Renewable Bioproducts Institute, was reported recently in the journal Nature Sustainability. Many industries that use large amounts of water in their production processes may stand to benefit from using these GO nanofiltration membranes.

Nair, his colleagues Meisha Shofner and Scott Sinquefield, and their research team began this work five years ago. They knew that GO membranes had long been recognized for their great potential in desalination, but only in a lab setting. “No one had credibly demonstrated that these membranes can perform in realistic industrial water streams and operating conditions,” Nair said. “New types of GO structures were needed that displayed high filtration performance and mechanical stability while retaining the excellent chemical stability associated with GO materials.”

To create such new structures, the team conceived the idea of sandwiching large aromatic dye molecules in between GO sheets. Researchers Zhongzhen Wang, Chen Ma, and Chunyan Xu found that these molecules strongly bound themselves to the GO sheets in multiple ways, including stacking one molecule on another. The result was the creation of “gallery” spaces between the GO sheets, with the dye molecules acting as “pillars.” Water molecules easily filter through the narrow spaces between the pillars, while chemicals present in the water are selectively blocked based on their size and shape. The researchers could tune the membrane microstructure vertically and laterally, allowing them to control both the height of the gallery and the amount of space between the pillars.

The team then tested the GO nanofiltration membranes with multiple water streams containing dissolved chemicals and showed the capability of the membranes to reject chemicals by size and shape, even at high concentrations. Ultimately, they scaled up their new GO membranes to sheets that are up to 4 feet in length and demonstrated their operation for more than 750 hours in a real feed stream derived from a paper mill.

Nair expressed excitement for the potential of GO membrane nanofiltration to generate cost savings in paper mill energy usage, which could improve the industry’s sustainability. “These membranes can save the paper industry more than 30% in energy costs of water separation,” he said.

Georgia Tech continues to work with its industrial partners to apply the GO membrane technology for pulp and paper applications. 

This work is supported by the U.S. Department of Energy (DOE) Rapid Advancement in Process Intensification Deployment (RAPID) Institute (#DE-EE007888-5-5), an industrial consortium comprising Georgia-Pacific, International Paper, SAPPI, and WestRock, and the Georgia Tech Renewable Bioproducts Institute. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the sponsoring organizations.

CITATION: Zhongzhen Wang, et al., “Graphene Oxide Nanofiltration Membranes for Desalination under Realistic Conditions.” (Nature Sustainability, 2021)  https://doi.org/10.1038/s41893-020-00674-3.

Does a dependency on a smart phone make you a cyborg? Does riding a bicycle? What about throwing spears at wooly mammoths?

The people behind the mics at the Georgia Tech Sci Fi Lab are deep in discussion. It’s Two-Minute Madness time on the WREK radio show. The hosts and special guests speed-talk through mentions of Dr. Who, iPhones, Lance Armstrong, Luke Skywalker, Neanderthals, the Six Million Dollar Man, Star Trek, Terminator and zombies — all in the quest of determining, what, specifically, makes something a cyborg.

“We can say that this week's topic is ‘cyborgs,’ for example, but that can mean different things to different people: from Darth Vader, to Google Glass, to Daft Punk,” said Adam Le Doux, program manager and a host of the show. When not on the air, he’s a computational media major, a joint studies program between the College of Computing and the School of Literature, Media, and Communication (LMC) in Ivan Allen College of Liberal Arts. LMC is one of the coordinators of Sci Fi Lab along with the Georgia Tech Library and WREK 91.1 FM.

Since 2006, Sci Fi Lab has taken to the radio waves to discuss all things science fiction. Every Thursday at 7 p.m. a group of culture studies researchers and computer thinkers gather to discuss the spectrum of science fiction. The show has been picking up traction with the science fiction community, both locally and nationally.

"Six years into the program, we find that now we're approached by authors and artists who want to appear on the show, and we've even been studied in the University of Liverpool's grad program in Science Fiction Studies as an example of living science fiction," said Lisa Yaszek, a professor in LMC and a behind-the-scenes Sci Fi Lab organizer.

October’s guests included players from the Atlanta Radio Theater Co., the director of an independent zombie apocalypse film, Georgia Tech computing professors and actor Frank Langella from “Robot and Frank.”

“We try to cover the best in current and popular science fiction from all media — literature, film, television — and we try to tie that in with the real science and research that occurs on campus every day,” said Justin Ellis, who shares hosting duties with Le Doux.

Ellis serves as associate producer for the show and works at the Georgia Tech Library. His time on the development committee for the science fiction collection connected him with Yaszek. She thought there was a strong role for the library to provide academic foundations for the show, so Ellis signed on.

“I think the fact that we try and tackle both the ‘pop’ side — literature and entertainment — and the real science, research side is one way to bridge the gap between the sciences and the liberal arts,” said Ellis. “Many of the topics discussed in Sci-Fi literature and media are extrapolated from, or have some root in, real science.”

At the start of two-minute madness during the cyborg hour, Ellis shares his enthusiasm for wearable computing. He muses that he would be game for a cybernetic implant in his arm.

Le Doux quickly counters that that could be problematic in a light saber battle.

It’s a discussion that underscores how Le Doux describes the show, as “a living laboratory for the intersection of liberal arts and science.” It’s a concept with which he identifies personally.

“My studies are evenly split between computer science and the liberal arts — communication, culture, design — so this kind of cross-pollination is something I'm into,” said Le Doux.

It’s also something that’s unique to Georgia Tech and its students. Sci Fi Lab is one way to expand that intersection beyond the campus and into the greater community.

“In the wider culture we tend to have a gap between the arts and the sciences, but both sides would gain a lot if they worked more closely together, and I like to think there is an increasing awareness of this,” said Le Doux. “I think what makes the Sci Fi Lab unique are the combined perspectives of the participants.”

During the cyborg hour, Ellis interviewed Georgia Tech faculty about their work. In a telling demonstration, Thad Starner, associate professor in the School of Interactive Computing, challenged Clint Zeagler, a research scientist in the College of Architecture, to a picture race. Starner tapped his Google Glasses and secured a photo nearly instantaneously. Zeagler was forced to wait for his phone to turn on before launching a photo app.

Then they talked about getting inspiration from fashion design and Terminator movies. The intersection of arts and science is unavoidable. Sci Fi Lab serves as the petri dish for deeper investigation.

Sci Fi Lab airs weekly on Thursdays at 7 p.m., WREK 91.1 FM. Archived shows can be found at www.wrek.org/scifilab. Photos courtesy Jason Ellis.

Does a dependency on a smart phone make you a cyborg? Does riding a bicycle? What about throwing spears at wooly mammoths?

The people behind the mics at the Georgia Tech Sci Fi Lab are deep in discussion. It’s Two-Minute Madness time on the WREK radio show. The hosts and special guests speed-talk through mentions of Dr. Who, iPhones, Lance Armstrong, Luke Skywalker, Neanderthals, the Six Million Dollar Man, Star Trek, Terminator and zombies — all in the quest of determining, what, specifically, makes something a cyborg.

“We can say that this week's topic is ‘cyborgs,’ for example, but that can mean different things to different people: from Darth Vader, to Google Glass, to Daft Punk,” said Adam Le Doux, program manager and a host of the show. When not on the air, he’s a computational media major, a joint studies program between the College of Computing and the School of Literature, Media, and Communication (LMC) in Ivan Allen College of Liberal Arts. LMC is one of the coordinators of Sci Fi Lab along with the Georgia Tech Library and WREK 91.1 FM.

Since 2006, Sci Fi Lab has taken to the radio waves to discuss all things science fiction. Every Thursday at 7 p.m. a group of culture studies researchers and computer thinkers gather to discuss the spectrum of science fiction. The show has been picking up traction with the science fiction community, both locally and nationally.

"Six years into the program, we find that now we're approached by authors and artists who want to appear on the show, and we've even been studied in the University of Liverpool's grad program in Science Fiction Studies as an example of living science fiction," said Lisa Yaszek, a professor in LMC and a behind-the-scenes Sci Fi Lab organizer.

October’s guests included players from the Atlanta Radio Theater Co., the director of an independent zombie apocalypse film, Georgia Tech computing professors and actor Frank Langella from “Robot and Frank.”

“We try to cover the best in current and popular science fiction from all media — literature, film, television — and we try to tie that in with the real science and research that occurs on campus every day,” said Justin Ellis, who shares hosting duties with Le Doux.

Ellis serves as associate producer for the show and works at the Georgia Tech Library. His time on the development committee for the science fiction collection connected him with Yaszek. She thought there was a strong role for the library to provide academic foundations for the show, so Ellis signed on.

“I think the fact that we try and tackle both the ‘pop’ side — literature and entertainment — and the real science, research side is one way to bridge the gap between the sciences and the liberal arts,” said Ellis. “Many of the topics discussed in Sci-Fi literature and media are extrapolated from, or have some root in, real science.”

At the start of two-minute madness during the cyborg hour, Ellis shares his enthusiasm for wearable computing. He muses that he would be game for a cybernetic implant in his arm.

Le Doux quickly counters that that could be problematic in a light saber battle.

It’s a discussion that underscores how Le Doux describes the show, as “a living laboratory for the intersection of liberal arts and science.” It’s a concept with which he identifies personally.

“My studies are evenly split between computer science and the liberal arts — communication, culture, design — so this kind of cross-pollination is something I'm into,” said Le Doux.

It’s also something that’s unique to Georgia Tech and its students. Sci Fi Lab is one way to expand that intersection beyond the campus and into the greater community.

“In the wider culture we tend to have a gap between the arts and the sciences, but both sides would gain a lot if they worked more closely together, and I like to think there is an increasing awareness of this,” said Le Doux. “I think what makes the Sci Fi Lab unique are the combined perspectives of the participants.”

During the cyborg hour, Ellis interviewed Georgia Tech faculty about their work. In a telling demonstration, Thad Starner, associate professor in the School of Interactive Computing, challenged Clint Zeagler, a research scientist in the College of Architecture, to a picture race. Starner tapped his Google Glasses and secured a photo nearly instantaneously. Zeagler was forced to wait for his phone to turn on before launching a photo app.

Then they talked about getting inspiration from fashion design and Terminator movies. The intersection of arts and science is unavoidable. Sci Fi Lab serves as the petri dish for deeper investigation.

Sci Fi Lab airs weekly on Thursdays at 7 p.m., WREK 91.1 FM. Archived shows can be found at www.wrek.org/scifilab. Photos courtesy Jason Ellis.

Does a dependency on a smart phone make you a cyborg? Does riding a bicycle? What about throwing spears at wooly mammoths?

The people behind the mics at the Georgia Tech Sci Fi Lab are deep in discussion. It’s Two-Minute Madness time on the WREK radio show. The hosts and special guests speed-talk through mentions of Dr. Who, iPhones, Lance Armstrong, Luke Skywalker, Neanderthals, the Six Million Dollar Man, Star Trek, Terminator and zombies — all in the quest of determining, what, specifically, makes something a cyborg.

“We can say that this week's topic is ‘cyborgs,’ for example, but that can mean different things to different people: from Darth Vader, to Google Glass, to Daft Punk,” said Adam Le Doux, program manager and a host of the show. When not on the air, he’s a computational media major, a joint studies program between the College of Computing and the School of Literature, Media, and Communication (LMC) in Ivan Allen College of Liberal Arts. LMC is one of the coordinators of Sci Fi Lab along with the Georgia Tech Library and WREK 91.1 FM.

Since 2006, Sci Fi Lab has taken to the radio waves to discuss all things science fiction. Every Thursday at 7 p.m. a group of culture studies researchers and computer thinkers gather to discuss the spectrum of science fiction. The show has been picking up traction with the science fiction community, both locally and nationally.

"Six years into the program, we find that now we're approached by authors and artists who want to appear on the show, and we've even been studied in the University of Liverpool's grad program in Science Fiction Studies as an example of living science fiction," said Lisa Yaszek, a professor in LMC and a behind-the-scenes Sci Fi Lab organizer.

October’s guests included players from the Atlanta Radio Theater Co., the director of an independent zombie apocalypse film, Georgia Tech computing professors and actor Frank Langella from “Robot and Frank.”

“We try to cover the best in current and popular science fiction from all media — literature, film, television — and we try to tie that in with the real science and research that occurs on campus every day,” said Justin Ellis, who shares hosting duties with Le Doux.

Ellis serves as associate producer for the show and works at the Georgia Tech Library. His time on the development committee for the science fiction collection connected him with Yaszek. She thought there was a strong role for the library to provide academic foundations for the show, so Ellis signed on.

“I think the fact that we try and tackle both the ‘pop’ side — literature and entertainment — and the real science, research side is one way to bridge the gap between the sciences and the liberal arts,” said Ellis. “Many of the topics discussed in Sci-Fi literature and media are extrapolated from, or have some root in, real science.”

At the start of two-minute madness during the cyborg hour, Ellis shares his enthusiasm for wearable computing. He muses that he would be game for a cybernetic implant in his arm.

Le Doux quickly counters that that could be problematic in a light saber battle.

It’s a discussion that underscores how Le Doux describes the show, as “a living laboratory for the intersection of liberal arts and science.” It’s a concept with which he identifies personally.

“My studies are evenly split between computer science and the liberal arts — communication, culture, design — so this kind of cross-pollination is something I'm into,” said Le Doux.

It’s also something that’s unique to Georgia Tech and its students. Sci Fi Lab is one way to expand that intersection beyond the campus and into the greater community.

“In the wider culture we tend to have a gap between the arts and the sciences, but both sides would gain a lot if they worked more closely together, and I like to think there is an increasing awareness of this,” said Le Doux. “I think what makes the Sci Fi Lab unique are the combined perspectives of the participants.”

During the cyborg hour, Ellis interviewed Georgia Tech faculty about their work. In a telling demonstration, Thad Starner, associate professor in the School of Interactive Computing, challenged Clint Zeagler, a research scientist in the College of Architecture, to a picture race. Starner tapped his Google Glasses and secured a photo nearly instantaneously. Zeagler was forced to wait for his phone to turn on before launching a photo app.

Then they talked about getting inspiration from fashion design and Terminator movies. The intersection of arts and science is unavoidable. Sci Fi Lab serves as the petri dish for deeper investigation.

Sci Fi Lab airs weekly on Thursdays at 7 p.m., WREK 91.1 FM. Archived shows can be found at www.wrek.org/scifilab. Photos courtesy Jason Ellis.

Jialei Chen, an industrial and systems engineering (ISyE) doctoral student and graduate research assistant in the Georgia Tech Manufacturing Institute (GTMI), won two Best Student Paper Awards at this year’s 2020 INFORMS Conference. The annual INFORMS conference on business analytics and operations research brings together nearly 1,000 leading analytics professionals and industry experts to share ideas, network and learn about a range of current topics and trends that can help businesses and organizations improve their analytics prowess by applying science to the art of business.

Chen won Best Student Paper Award in the Quality, Statistics, and Reliability track for “Adaptive Design for Gaussian Process Regression under Censoring.” This paper presented an experimental design and modeling method for censored physical experiments. Censoring is commonly encountered in experimentation due to the limits in a measurement device, safety considerations of the experimenter, and a fixed experimental time budget. To tackle this, he proposed a novel adaptive design method, which first estimates the possibility of censoring and then adaptively chooses design points to minimize predictive uncertainty under censoring. He demonstrates the effectiveness of the proposed method in two real-world applications on surgical planning and wafer manufacturing.

Chen won Best Student Paper Runner-up Award in the Data Mining track for “APIK: A Physics-Informed Kriging Model with Partial Differential Equations.” This paper presented a learning framework that combines limited data and the auxiliary partial differential equations. One of the key challenges in applying state-of-the-art machine learning methods in real-world engineering applications is that the available measurement data is scarce. In this work, he proposed to incorporate the auxiliary partial differential equations in the learning model and therefore improve the predive performance. The proposed APIK model can leverage linear and nonlinear PDEs and enjoy simple and closed-form prediction and uncertainty quantification. He applied the proposed method to two real-world applications on flow dynamics and thermal processes.

Chen’s advisors for both papers were Georgia Tech ISyE professors Chuck Zhang and Roshan Joseph.

“I’m honored to have won best student paper award in the quality, statistics, and reliability track at INFORMS 2020, and to have another paper win second place in the data mining track,” said Chen. “My research focuses on engineering-driven learning methodologies, and data-driven modeling for complex engineering and manufacturing systems. The two awards are a great encouragement for me and inspire me to accomplish more in-depth and impactful works in the future. I would like to express my highest gratitude to my supervisors, professors Chuck Zhang and Roshan Joseph. I would also like to thank the support and assistance from GTMI, which helped to make the two projects possible.”

BioFabUSA, a Department of Defense-funded Manufacturing Innovation Institute within the Manufacturing USA network, has awarded the Georgia Institute of Technology and industry partner Rockwell Automation a project entitled, “Wireless Electrochemical Sensor Capsules for Real-Time Monitoring of Cell Secretomes and Culture Media in Tissue Growth Bioreactors.” Real-time bioprocess monitoring and control is needed for the scalable production and deployment of efficacious tissue engineered medical products (TEMPs) at reasonable cost.

Billyde Brown, the project's principal investigator, explained, “we are addressing this challenge by working with BioFabUSA, our partners at the Georgia Tech School of Materials Science and Engineering, the Marcus Center for Therapeutic Cell Characterization and Manufacturing, as well as Rockwell Automation, to develop a fully integrated, wireless, 3D-printed sensor ‘capsule’ to be used for in-situ multiplexed monitoring of critical quality attributes (CQAs). The targeted CQAs include pH, glucose, lactate, and select secreted biomarker concentrations from human mesenchymal stem cells – one of the most common cell types used in tissue engineering.”

In both biopharmaceutical and regenerative medicine industries, an urgent need remains for in-line sensor technology for quantitative real-time bioprocess monitoring and control. Unfortunately, many key CQAs are still monitored off-line or at-line using destructive testing or technologies of significant complexity and cost. In at-line measurement, the sample is typically withdrawn from a single location in the bioreactor and analyzed in close proximity to the process stream, whereas in off-line measurements, the sample is taken to a laboratory and the results are usually not returned in a timely manner for process control.

The Georgia Tech team has previously developed potentiometric sensors based on an extended gate field-effect-transistor (FET) topology whereby a separate gold electrode surface is functionalized with an analyte-specific layer that selectively reacts or binds with the chemical or biomolecule of interest. The charge associated with the attached analyte results in a potential change of the gold electrode. These sensors have previously been used to detect chemicals such as pH and lactate, as well as specific proteins/antibodies in a laboratory environment with accuracy and dynamic range equivalent to Surface Plasmon Resonance (SPR) and Enzyme-Linked Immunosorbent Assay (ELISA). One of the unique aspects of this system is that each sensor surface can be individually functionalized permitting multiplexed (simultaneous) detection of almost any number of different chemicals/biomolecules of interest.

In this project, the Georgia Tech team will integrate these sensors into a “capsule” device smaller than the size of a golf-ball and packaged in a 3D-printed waterproof and biocompatible polymer. The capsule will contain a multiplexed sensor chip, with sealed opening to facilitate interaction between the sensor chip and tissue culture environment, Li-polymer battery, and electronics for micro-control, data acquisition and wireless transmission of sensor data to the smartphone of a technician in charge of monitoring the bioreactor process. In addition, Georgia Tech will work with Rockwell to develop an IoT platform such that other permitted internet-connected devices can securely access the data via a cloud server. Another unique aspect of this technology is that multiple “capsules” could be deployed within a stirred tank bioreactor during high volume production of medical products with the ability to move efficiently throughout the bioreactor due to the mechanical forces of the impellors. This would allow for unprecedented simultaneous measurements at various points within the bioreactor, giving accurate representations of the homogeneity of key parameters over time thus achieving in-situ monitoring of CQAs with high spatial and temporal resolution.

Georgia Tech project leads include Billyde Brown, Ph.D., Kan Wang, Ph.D., and Eric Vogel, Ph.D. Brown is research faculty and director of manufacturing education programs at the Georgia Tech Manufacturing Institute (GTMI). Wang is lead researcher of additive manufacturing in the Bio-Engineering Research Laboratory at GTMI. Vogel is a professor at the School of Materials Science and Engineering and deputy director for the Institute of Electronics and Nanotechnology at Georgia Tech. The Georgia Tech project leads will also receive support and assistance from Carolyn Yeago, Ph.D., and Krishnendu Roy, Ph.D. whom are directors of the Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M). Leading the project for Rockwell Automation is Wayne Charest, who also serves as a liaison between Rockwell and BioFabUSA.

“Being able to obtain real-time data on relevant biomarkers will be critical in advancing the field of tissue engineering,” said Stephanie Robichaud, technical project manager with the Advanced Regenerative Manufacturing Institute. “Getting this important information and being able to react to it quickly will result in more consistent manufacturing of a final product that meets its critical quality attributes.”

 

About the Georgia Institute of Technology

The Georgia Institute of Technology, also known as Georgia Tech, is one of the nation’s leading research universities — a university that embraces change while continually Creating the Next. The next generation of leaders. The next breakthrough startup company. The next lifesaving medical treatment.

Georgia Tech provides a focused, technologically based education to more than 36,000 undergraduate and graduate students. The Institute has many nationally recognized programs, all top-ranked by peers and publications alike, and is ranked among the nation’s top five public universities by U.S. News & World Report. It offers degrees through the Colleges of Computing, Design, Engineering, Sciences, the Scheller College of Business, and the Ivan Allen College of Liberal Arts. As a leading technological university, Georgia Tech has more than 100 centers focused on interdisciplinary research that consistently contribute vital research and innovation to American government, industry, and business. https://www.gatech.edu/

About Rockwell Automation

Rockwell Automation is the largest company in the world that is dedicated to industrial automation and information and is committed to enabling the next generation of smart manufacturing.  Rockwell’s mission is to improve the quality of life by making the world more productive and sustainable.

https://www.rockwellautomation.com

 

About BioFabUSA

BioFabUSA is a DOD-funded Manufacturing USA Innovation Institute (MII) sustained by the Advanced Regenerative Manufacturing Institute (ARMI), a non-profit organization located in Manchester, New Hampshire.  ARMI's mission is make practical the scalable, consistent, cost-effective manufacturing of tissue engineered medical products and tissue-related technologies, to benefit existing industries and grow new ones.  https://www.armiusa.org/

 

Georgia Tech Manufacturing Institute
813 Ferst Drive, NW
Atlanta, GA 30332 USA

Media Relations Contact: Walter Rich (walter.rich@research.gatech.edu)

BioFabUSA, a Department of Defense-funded Manufacturing Innovation Institute within the Manufacturing USA network, has awarded the Georgia Institute of Technology and industry partner, Akron Biotech, a project titled, “Supply Chain and Process Modeling Algorithms, Methods, and Tools for Tissue Manufacturing and Distribution”. This project will address significant national supply chain issues related to distributing tissue engineered medical products (TEMPs) to U.S. patients in need.

The project aims to create the first simulation-based supply chain model for the rapidly evolving and future facing TEMPs industry, to minimize manufacturing and logistics costs and risks, incorporate Department of Defense (DOD) and other stakeholders’ perspectives into supply chain modeling, inform standards development, and support workforce development. 

“Having a supply chain model will be instrumental in helping new and existing companies plan for the most efficient process flows, resource usage, and cost savings,” said Stephanie Robichaud, technical project manager with the Advanced Regenerative Manufacturing Institute. “Many startup companies do not realize some of the intricacies in managing their supply chain and many established companies realize the importance of it after experiencing inefficiencies. Having a model that these companies can use will help advance the field of tissue engineering as they plan for scale-up.”

According to Ben Wang, executive director of the Georgia Tech Manufacturing Institute (GTMI) and professor in the Stewart School of Industrial and Systems Engineering, “hundreds if not thousands of patients are waiting for tissues and organs in order to have a normal healthy life. Our project is a bold initiative to democratize distribution of replacement tissues and organs by streamlining national supply chains. This project will develop simulation-based tools to enhance the efficiency and resilience of the TEMPs supply chain, making these personalized medicines more affordable and more accessible.”

The growth of the TEMP industry is going to change the supply chain of medical tissues disruptively. To embrace this change, a system-level decision support tool is essential for adopting more cost-effective manufacturing processes and making better investment decisions. To ensure successful commercialization and adoption of this new supply chain decision support tool, the project team will engage multiple stakeholders including DOD, government, regulatory bodies, standards setting organizations, patients, industry, academia, policy experts, education and workforce development experts.

Georgia Tech project leads include Ben Wang, Ph.D., Chelsea C. White III, Ph.D, and Kan Wang, Ph.D. Ben Wang is Gwaltney Chair in Manufacturing Systems, professor in the Stewart School of Industrial & Systems Engineering and School of Materials Science and Engineering at Georgia Tech. In addition, he serves as executive director of the Georgia Tech Manufacturing Institute (GTMI). Chelsea C. White III is the Schneider National Chair in Transportation and Logistics and professor in the H. Milton Stewart School of Industrial and Systems Engineering at Georgia Tech​. Kan Wang is lead researcher of additive manufacturing in the Bio-Engineering Research Laboratory at GTMI.

Leading the project for Akron Biotech is Ezequiel Zylberberg, Ph.D, who is vice president of product development and planning. According to Ezequiel, “the future of regenerative medicine depends on more than our ability to address the scientific challenges of generating the next generation of advanced therapies. Advancing these novel treatments in a way that is scalable will require significant advances in manufacturing innovation. We are eager to collaborate with our colleagues at Georgia Tech, at BioFab USA, and throughout the regenerative medicine industry to confront the challenge of scalability and supply chain resilience through this modelling effort.”  

 

About the Georgia Institute of Technology

The Georgia Institute of Technology, also known as Georgia Tech, is one of the nation’s leading research universities — a university that embraces change while continually Creating the Next. The next generation of leaders. The next breakthrough startup company. The next lifesaving medical treatment.

Georgia Tech provides a focused, technologically based education to more than 36,000 undergraduate and graduate students. The Institute has many nationally recognized programs, all top-ranked by peers and publications alike, and is ranked among the nation’s top five public universities by U.S. News & World Report. It offers degrees through the Colleges of Computing, Design, Engineering, Sciences, the Scheller College of Business, and the Ivan Allen College of Liberal Arts. As a leading technological university, Georgia Tech has more than 100 centers focused on interdisciplinary research that consistently contribute vital research and innovation to American government, industry, and business. https://www.gatech.edu/

About Akron Biotech

Akron is a leading materials manufacturer and services provider to the regenerative medicine industry, accelerating the development and commercialization of advanced therapies. Founded in 2006, Akron is an ISO 13485-certified company that operates in line with cGMPs and international standards, enabling advanced therapy developers to de-risk their supply chains and facilitate regulatory approval. The company's unique business model emphasizes knowledge, flexibility and unparalleled service—from development through to commercialization. For more information, please visit www.akronbiotech.com.

About BioFabUSA

BioFabUSA, is a DOD-funded Manufacturing USA Innovation Institute (MII) sustained by the Advanced Regenerative Manufacturing Institute (ARMI) is a non-profit organization located in Manchester, New Hampshire. ARMI's mission is to make practical the scalable, consistent, cost-effective manufacturing of tissue engineered medical products and tissue-related technologies, to benefit existing industries and grow new ones.  https://www.armiusa.org/

 

Georgia Tech Manufacturing Institute
813 Ferst Drive, NW
Atlanta, GA 30332 USA

Media Relations Contact: Walter Rich (walter.rich@research.gatech.edu)

Jialei Chen, a Ph.D. student in the H. Stewart School of Industrial & Systems Engineering at Georgia Tech and a research assistant in the Georgia Tech Manufacturing Institute, was awarded the Ellis R. Ott Scholarship For Applied Statistics and Quality Management from the American Society for Quality. The Ellis R. Ott Scholarship Governing Board selected Chen to receive this year's award in the Ph.D. category and he will receive a check in the amount of $7,500.

Chen’s research interests are in statistical modeling, machine learning, and experimental design with applications to mechanical engineering, biomedical engineering, advanced manufacturing, and healthcare. He is especially interested in engineering-driven data analytics for real-world challenges.

One of Chen’s research topics is to improve the surgical success rate of a common, yet severe heart disease called aortic stenosis. Specifically, he developed a 3D-printing-enabled “virtual patient” framework for in-vitro studies as pre-surgical planning. In order to make the “virtual patient” pathologically identical to the actual patient, he proposed to use a bio-inspired metamaterial design and a statistical emulation model for structure optimization. With the proposed method, the printed heart can mimic both the geometry and the mechanical property of a specific patient.

He previously worked on chimeric antigen receptor T cell therapy with the goal of developing new impedance sensing hardware and software.

Chen’s current research focuses on tackling two healthcare challenges resulting from COVID-19 by developing novel methodologies in the fields of statistics, quality engineering, and advanced manufacturing. The healthcare problems he is addressing include how to improve the recovery rate of a treatment, and how to reduce the cost to make the treatment available to everyone.