Nylon, Teflon, Kevlar. These are just a few familiar polymers — large-molecule chemical compounds — that have changed the world. From Teflon-coated frying pans to 3D printing, polymers are vital to creating the systems that make the world function better. 

Finding the next groundbreaking polymer is always a challenge, but now Georgia Tech researchers are using artificial intelligence (AI) to shape and transform the future of the field. Rampi Ramprasad’s group develops and adapts AI algorithms to accelerate materials discovery. 

This summer, two papers published in the Nature family of journals highlight the significant advancements and success stories emerging from years of AI-driven polymer informatics research. The first, featured in Nature Reviews Materials, showcases recent breakthroughs in polymer design across critical and contemporary application domains: energy storage, filtration technologies, and recyclable plastics. The second, published in Nature Communications, focuses on the use of AI algorithms to discover a subclass of polymers for electrostatic energy storage, with the designed materials undergoing successful laboratory synthesis and testing. 

“In the early days of AI in materials science, propelled by the White House’s Materials Genome Initiative over a decade ago, research in this field was largely curiosity-driven,” said Ramprasad, a professor in the School of Materials Science and Engineering. “Only in recent years have we begun to see tangible, real-world success stories in AI-driven accelerated polymer discovery. These successes are now inspiring significant transformations in the industrial materials R&D landscape. That’s what makes this review so significant and timely.”

AI Opportunities

Ramprasad’s team has developed groundbreaking algorithms that can instantly predict polymer properties and formulations before they are physically created. The process begins by defining application-specific target property or performance criteria. Machine learning (ML) models train on existing material-property data to predict these desired outcomes. Additionally, the team can generate new polymers, whose properties are forecasted with ML models. The top candidates that meet the target property criteria are then selected for real-world validation through laboratory synthesis and testing. The results from these new experiments are integrated with the original data, further refining the predictive models in a continuous, iterative process. 

While AI can accelerate the discovery of new polymers, it also presents unique challenges. The accuracy of AI predictions depends on the availability of rich, diverse, extensive initial data sets, making quality data paramount. Additionally, designing algorithms capable of generating chemically realistic and synthesizable polymers is a complex task. 

The real challenge begins after the algorithms make their predictions: proving that the designed materials can be made in the lab and function as expected and then demonstrating their scalability beyond the lab for real-world use. Ramprasad’s group designs these materials, while their fabrication, processing, and testing are carried out by collaborators at various institutions, including Georgia Tech. Professor Ryan Lively from the School of Chemical and Biomolecular Engineering frequently collaborates with Ramprasad’s group and is a co-author of the paper published in Nature Reviews Materials.

"In our day-to-day research, we extensively use the machine learning models Rampi’s team has developed,” Lively said. “These tools accelerate our work and allow us to rapidly explore new ideas. This embodies the promise of ML and AI because we can make model-guided decisions before we commit time and resources to explore the concepts in the laboratory."

Using AI, Ramprasad’s team and their collaborators have made significant advancements in diverse fields, including energy storage, filtration technologies, additive manufacturing, and recyclable materials.

Polymer Progress

One notable success, described in the Nature Communications paper, involves the design of new polymers for capacitors, which store electrostatic energy. These devices are vital components in electric and hybrid vehicles, among other applications. Ramprasad’s group worked with researchers from the University of Connecticut.

Current capacitor polymers offer either high energy density or thermal stability, but not both. By leveraging AI tools, the researchers determined that insulating materials made from polynorbornene and polyimide polymers can simultaneously achieve high energy density and high thermal stability. The polymers can be further enhanced to function in demanding environments, such as aerospace applications, while maintaining environmental sustainability. 

“The new class of polymers with high energy density and high thermal stability is one of the most concrete examples of how AI can guide materials discovery,” said Ramprasad. “It is also the result of years of multidisciplinary collaborative work with Greg Sotzing and Yang Cao at the University of Connecticut and sustained sponsorship by the Office of Naval Research.”

Industry Potential

The potential for real-world translation of AI-assisted materials development is underscored by industry participation in the Nature Reviews Materials article. Co-authors of this paper also include scientists from Toyota Research Institute and General Electric. To further accelerate the adoption of AI-driven materials development in industry, Ramprasad co-founded Matmerize Inc., a software startup company recently spun out of Georgia Tech. Their cloud-based polymer informatics software is already being used by companies across various sectors, including energy, electronics, consumer products, chemical processing, and sustainable materials. 

“Matmerize has transformed our research into a robust, versatile, and industry-ready solution, enabling users to design materials virtually with enhanced efficiency and reduced cost,” Ramprasad said. “What began as a curiosity has gained significant momentum, and we are entering an exciting new era of materials by design.”

CREATE-X is built to help students integrate entrepreneurship into their academic journey through courses, workshops, and a startup accelerator. This spring, a new set of students displayed their solutions to real-world problems at the I2P Showcase. It’s our privilege to shine a light on and celebrate those journeys. Today’s spotlight focuses on the spring I2P Showcase third-place winners. 

Electrosuit 

Aubrey Hall, a first-year biomedical student, and Sherya Chakraborty, a first-year computer science major, founded a startup to produce a garment that eases the use of at-home, prescribed electrical stimulation for people with chronic pain, stroke, and motor impairments.

What made you interested in building this solution?

“I did research at Northwestern for a couple of years before this, and some of the patients I worked with had severe stroke and spasticity in their arms,” Chakraborty said. “I found out that when they tried using at-home prescribed electrical stimulation, they had trouble setting it off themselves. So, we created a garment to ease pressure on that.”

What part of the course was most helpful to you?

“One of our mentors, Sun Mi Park, was the first person to patent printable wires on fabric, and that gave us some inspiration to make our garment even more compact, easier to use, and integrate some interesting ideas that we wouldn’t have been able to without our mentors. So, our mentors are honestly the best part of the program,” Chakraborty said.

“For me, you don’t get a lot of chances to apply these engineering courses outside of the classroom,” said Hall. “This course is a really interesting way to get firsthand experience building a prototype and really understand the engineering process.”

What’s so special about CREATE-X?

“I think these student projects are the future, and a lot of these projects make it out of college and become actual companies. Giving students that possibility to make a change just from a simple idea and fueling that with funding so we don’t have to take risks out of our own pockets is a, really big deal,” Chakraborty said.

“It’s helpful to have that safety net, knowing that you have your mentors to back you, and also the people of the program to back you. It brings a lot of security and opportunity to try different things out and not have to be so fearful of failure. Even if you fail a million times, you can get back up and try again,” Hall said.

What’s the best insight you’ve gained from doing this?

“I think one big misconception is that entrepreneurship has a lot to do with finance and business and just lucrative ideas, but it’s pretty important to understand that you can solve a seemingly everyday problem,” said Chakraborty. “If it affects you or your friends, it’s still worth trying to find a way to solve it, especially backed up with money and mentors from CREATE-X. What’s the harm in trying something out?” 

“Don’t try to make it feel like it’s an all-or-nothing project,” Hall said. “You’re allowed to live your life as a college student but also pursue these interesting ideas and figure out if you enjoy entrepreneurship. It shouldn’t be this daunting task where if you don’t put everything in, you’re going to fail.”

“It’s also important to keep an open mind. We might come in with an idea and a very specific way of executing that idea, but we found out through talking with mentors, and with other students and people who gave us advice, that sometimes the idea you come in with is not going to be the same thing you end up with,” Chakraborty said. 

Next Steps

“We’ve only done four or five prototypes so far,” she noted. “We want to do at least 12 of those prototypes and keep working with our mentors, keep making connections at Emory, and just constantly getting more and more feedback about our prototypes until we get to a state where we’re satisfied, and we can demo our product and work with physical therapists across Atlanta.”

If you’re a student interested in building your own product for college credit, apply for I2P. And join us for Demo Day, Aug. 29, at 5 p.m., in the Georgia Tech Exhibition Hall to see new CREATE-X founders launch products in a variety of industries. Tickets are free but limited. Register today to secure your spot.

During the school year and the summer, Georgia Tech students can incorporate entrepreneurship into their college experience through courses, workshops, special events, and even a startup accelerator. CREATE-X invites you to delve into the journeys of our top achievers, this time focusing on the Spring 2024 I2P Showcase first-place winners: 

Dolfin Solutions

Marianna Cao, James Gao, and Jaeheon Shim, first-year computer science majors, are the founders of Dolfin Solutions, a personal financial management platform that promises a unified solution to budgeting, transaction management, and expense tracking, among other personal finance tasks. 

What challenges did you have in I2P, and how did you work through them?

 “We were really lucky to get an excellent mentor, Aaron Hillegass. He has a lot of experience in the industry as a startup founder himself, and he gave us a lot of help, both technical as well as business, throughout the process. That helped us make better decisions,” Gao said.

“I think the biggest challenge was, I had done projects in the past by myself, writing the full stack, but working together, communicating the requirements, and integrating everyone's different code at the end was a little bit of a logistical struggle,” Shim said. “But we managed to figure it out.”

What advice do you have for students interested in I2P or entrepreneurship in general?

“Go for it. It's a three-credit course, so it counts toward your junior capstone as well. You get $500. Now is the perfect time to start because you don't have much to lose. If you're doing I2P and your company fails, you still have four years of college; you can still pursue a traditional path. It's a little risk but a lot to gain,” Shim said.

“Even if you pivot or change your idea, it's important to believe in what you started,” said Cao. “If you don't believe in your app, then nobody else does. Right now, you have all of the friends, mentors, professors, and the right resources, and money is not an issue. It's a good opportunity for you to work on it on the side, and maybe it could turn into something.”

What’s Next?

“We’re going to build for the iOS and Android platforms, and then we're going to deploy hopefully by the end of summer,” Shim said. 

If you’re a student interested in building your own product for college credit, apply for I2P. And join us for Demo Day, Aug. 29, at 5 p.m., in the Georgia Tech Exhibition Hall to see new CREATE-X founders launch products in a variety of industries. Tickets are free but limited. Register today to secure your spot.

Nakia Melecio, the VentureLab Principal under the Office of Commercialization, has made remarkable progress in enhancing the grant programs of the National Institutes of Health (NIH). Over an intensive eight-month period, Melecio was part of an evaluation committee that focused on refining initiatives of the NIH’s National Cancer Institute, particularly the Small Business Transition Grant and other related grant programs.

“The experience was both enlightening and challenging,” Melecio said. “We engaged with faculty from over 20 universities to understand the diverse needs — from early-stage research to the commercialization of technology.” His pivotal role in streamlining the application processes for the Small Business Innovation Research and Small Business Technology Transfer programs has significantly enhanced their efficiency and accessibility.

A key aspect of Melecio’s efforts was to increase participation from historically underrepresented groups, with a significant focus on supporting historically Black colleges and universities and minority-serving institutions. His strategic insights have helped reshape these programs to better facilitate the commercialization of technologies developed within academic institutions.

Keith McGreggor, director of VentureLab, praised Melecio’s contributions. “Nakia’s work embodies our mission to transform research into viable market opportunities, ensuring broad access and benefit. The approval of the committee’s recommendations by the NCI leadership marks a significant advancement in our ongoing effort to make NIH funding more accessible and effective,” he said.

As these enhancements are implemented, they promise to significantly improve the landscape for commercializing technologies originating from university research, fostering broader innovation and practical application of groundbreaking discoveries.

The Office of Commercialization at Georgia Tech continues to support faculty and researchers as they navigate these improved opportunities, ensuring that the leadership and expertise within our community are directed toward national and global advancements in science and technology.

Stay engaged with the Office of Commercialization for ongoing updates on this and other initiatives.

Parth Arora is the founder of Third Dimension Fitness, a platform for gamified cardio through mixed reality, which was recently acquired by Elbo, an education-focused company based in Singapore. He began his company as a project in the summer of 2022. Since then, it has gained thousands of users and made thousands in revenue each month. Arora is a senior in computer science. He participated in the Spring 2024 Startup Launch, the first cohort to be held outside of the summer program. Below is a Q&A with Arora. 

Did you always want to be an entrepreneur?

I always did. I had my first company, an educational technology app, when I was 16, which ran for about two years. I ended it in my first year of college. I'm from India originally and the vision was to provide resources to the larger mass market of India for extracurricular activities. But, we realized there wasn't a business model. When we tried to make money, we started serving the rich kids. When we tried to serve the market, we didn't make money, which doesn't make investors happy, though we did end up making enough money to repay them.

That didn't stop me; it just gave me more lessons. 

What other experience in entrepreneurship have you had?

I've been involved in entrepreneurship communities at Georgia Tech forever. I was co-director of Startup Exchange, which is where I met a lot of really driven people. I got a chance to build their fellowship program and initiate their first pitch competition, which is now called Summit. I've collaborated with CREATE-X for different events, and I try to attend any event hosted by CREATE-X, Startup Exchange, or ATDC.

Why did you choose to join the spring cohort of Startup Launch this year?

CREATE-X provides everything you need, like legal support, financial support, sales support, mentors, and an introduction to VCs, which is why I decided to join the Launch program. I think all of that boosted our startup’s growth.

Why did you feel like acquisition was the way to go for your company?

I think because I always knew this wasn’t “the” thing I was going to do. This summer I'll be starting to work for Apple on their VisionPro team, and it has a direct conflict-of-interest. They wanted me to stop working on this for a while. So, I felt like this might be a good time to explore the acquisition.  We had really rich content, which had proven to work. We had curated that content after hundreds of customer interviews, and we had advisors from Nike, Disney, and Netflix. I knew that was a strong point, so that's why I knew that acquisition would be a good exit. 

What support have you had in taking the acquisition path?

Seth [Radman, who has had multiple exits himself and is a Startup Launch alumnus] has been guiding me professionally for a while. I met him at previous events through Startup Exchange, but then he recently came to a CREATE-X event. Rahul [Saxena, CREATE-X director], has also been a great support for me since day one. He was the one who suggested Startup Launch to me.

In December of last year, we started monetizing. We were testing different things. It was helpful to share the numbers and the data points with Rahul, mentors, and other people in my cohort so that I was not blindsided, and I could take actions based on the educated analysis of a database. It helped me drive down our customer acquisition cost, increase our customer lifetime value, and didn't keep me in my own bubble.

How were you okay with letting that product go?

It was a tough decision; it was my baby. I'd been working on it 10 to 15 hours a day, at least for the last few months. Rahul and Seth convinced me that if this is not the thing you want to do long-term and you know the market isn't big enough, you should move on to the next thing and put your time and energy there. 

I had to use my brain, and not my heart.

What's the biggest piece of advice that you've received as you developed your company?

Try to never lie to yourself, which is harder than it seems. I've built two companies and worked with several others, and I still lie to myself. When you love your product so much, it's very easy to lie to yourself about how there is a market for it, or people are using it. I think even in the future, I’ll probably be caught doing that, but the best way I've found to overcome that is to surround yourself with people who can tell you when you are doing it and help you see your company the way it is instead of the way you want it to be.

How has this decision affected you so far?

My lifestyle has completely changed, from looking at a dashboard every 10 to 15 minutes, seeing how the product is doing, and burning so many fires every 30 minutes, to being pretty chill. Like, what am I supposed to think about before I go to bed? What am I supposed to do now? Who are the customers I am supposed to be thinking about? It's been interesting, but I think this gives me space to now work on that next venture and have more time to think about what I want to do next.

Do you think you'll want to return to entrepreneurship in the future?

Yes, for sure. All the money I received from the acquisition will also fuel my next venture. My main goal is to grow in this industry. I'm an entrepreneur at heart, so I will be returning to the space soon or building products that people like. 

How are you celebrating this win?

I did celebrate it on our last day with Rahul, my amazing mentor, Margaret [Weniger, who founded Rising Tide], and the other cohort members. I will be celebrating it with a few of my friends because my 21st birthday is coming around, so I'll be celebrating these occasions together. 

But I don't want to take the money out from the company or for anything else, because it’s for my next venture. It shouldn't change my lifestyle at all, so I've kept all that money in a separate place.

What encouragement would you give to students interested in pursuing a startup?

Relative to other colleges, we have a cushion, a sense of security that we will get good jobs. Entrepreneurship is a riskier and more unpredictable path, which I've seen, and I'm personally experiencing right now having to choose between Big Tech versus entrepreneurship. But once you start building it and when you hear from your first customer how you affected the way they live, then there's no going back. Statistically, you'll probably fail, but you won't know until you start building; and if you do fail, it’ll teach you so many valuable lessons that are applicable in whatever career path you choose.

CREATE-X will launch its 12th cohort of Startup Launch on Aug. 29 at 5 p.m. in the Georgia Tech Exhibition Hall. Register today to secure your spot.

Interested in becoming a CREATE-X supporter? Startup Launch is made possible by contributions to Transforming Tomorrow, a $2 billion comprehensive campaign designed to secure resources that will advance the Institute and its impact, and by the continued engagement of our entrepreneurial ecosystem. Learn more about philanthropy at Georgia Tech and donate by visiting transformingtomorrow.gatech.edu.

To become a mentor in CREATE-X, visit the CREATE-X mentorship page. Any other inquiry may be sent to create-x@groups.gatech.edu. We appreciate your help and commitment to supporting our students in research and innovation.